Retinal Manifestations of Ocular Lymphoma (Reticulum Cell Sarcoma)

Intraocular lymphoma: a series of 14 patients with clinicopathological features and treatment outcomes

“…Only one (12.5%) of these eight patients with PCNSL developed systemic disease, comparable to the incidence of less than 10% systemic disease previously reported. 21,38 Two of our patients (14%) had ocular lymphoma with no proven CNS or systemic disease, although one patient developed a paraneoplastic cerebellar syndrome. However, autopsy was not performed.…”

“…Of 23 published cases with clinical data, [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] nine (39%) were associated with mycosis fungoides (primary T-cell malignancy of skin), 20,24,25,27,[29][30][31][32]34,35 10 (43%) with systemic (nonmycosis) lymphoma, [17][18][19]22,23,[26][27][28]33 two (9%) with CNS and intraocular lymphoma only, 17,20 and two (9%) were restricted to the eye only. 18,21 Therefore, systemic disease is found in 82% of patients with T-cell intraocular This was the total dose administered to the cranial vault and orbits. Details regrading the exact dose administered to the orbits were unavailable.…”

“…17,18 The two reported cases of intraocular T-cell lymphoma without systemic or CNS lymphoma were alive with a relatively short follow-up of 6 and 18 months. 18,21 Follow-up of those two cases was available only for one of the T-cell PCNSL involving the eye, who was alive at 27 months, 17 but the other HIV-positive patient has presumably died. 20 Interestingly, there is a male predominance of 2:1 for T-cell intraocular lymphoma, and the median age of onset for men is 46 years compared to 59 years for women.…”

Primary intraocular lymphoma mimicking multifocal choroiditis and panuveitis

“…The subretinal deposit of lymphoma resolved simultaneously with the fellow eye appearance of white retinal infiltrates and haemorrhage, a picture associated with PIOL. 4 Clinicians faced with a picture of multifocal choroiditis and panuveitis in an elderly patient should include primary intraocular lymphoma in the differential diagnosis and consideration of vitreous biopsy given. Early treatment has been associated with improved survival.…”

Molecular pathology of primary intraocular lymphoma

“…Sometimes PIOL may mimic a viral retinitis that is characterized by large areas of yellow creamy infiltrates, retinal hemorrhages, vasculitis, detachment, and necrosis. [25][26][27] The most common characteristics of the fluorescein angiograms show disturbances at the level of retinal pigment epithelium (RPE), including window defects that appear to correspond to tumor infiltrates at the level of RPE (Figure 2). 3,18,28 Both hyperfluorescent and hypofluorescent lesions can be observed.…”