Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis

Trip, S Anand; Schlottmann, Patricio G.; Jones, Stephen J.; Altmann, Daniel R.; Garway-Heath, David F.; Thompson, Alan J.; Plant, Gordon T.; Miller, David H.

doi:10.1002/ana.20575

Cited by 475 publications

(330 citation statements)

References 38 publications

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“…In this study, our data demonstrated the thinning of RNFL in Chinese patients with MS. In a retrospective cross-sectional study, Trip et al [19] reported no difference in RNFL between MS patients without ON and healthy controls; our study, however, demonstrated a significant difference (p = 0.001).…”

Section: Discussioncontrasting

confidence: 88%

The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

et al. 2013

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Background/Aims: Retinal nerve fiber layer (RNFL) thinning has been observed on histopathology and time-domain optical coherence tomography in many diseases of the central nervous system. In this study, with a higher resolution of spectral-domain optical coherence tomography (SDOCT), we detected RNFL changes in patients with multiple sclerosis (MS) in China, and compared RNFL thickness between eyes with and without optic neuritis (ON). Methods: In this retrospective, nonrandom case study, the patients were recruited from the Affiliated Sir Run Run Shaw Hospital of Zhejiang University. RNFL thickness was measured for each eye using SDOCT. The controls were recruited from the healthy population. Results: Peripapillary RNFL thickness of 24 eyes in 12 patients was detected by SDOCT. The average RNFL thickness of the MS patients was 81.9 ± 17.8 µm compared to the control value of 102.1 ± 8.1 µm (p = 0.00). The average RNFL of the patients with a history of ON was thinner than that of patients without ON (71.8 ± 19.2 µm vs. 92.0 ± 8.5 µm, p = 0.001). Conclusion: The RNFL thinning in Chinese patients with MS can be detected by SDOCT. The SDOCT scan represents a high-resolution, objective, noninvasive and easily quantifiable in vivo biomarker of MS.

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Section: Discussioncontrasting

confidence: 88%

The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

et al. 2013

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“…With regards to retinal imaging devices, GDx and optical coherent tomograph are primarily utilized in patients with ocular hypertension and chronic glaucoma [14, 15]. These instruments have proven to be useful in other types of optic neuropathies, including demyelizating diseases of the optic nerve or ON [16,17,18,19,20]. …”

Section: Discussionmentioning

confidence: 99%

Nerve Fibre Layer Analysis with GDx with a Variable Corneal Compensator in Patients with Multiple Sclerosis

et al. 2007

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Purpose: To evaluate the ability of GDx with variable corneal compensator (VCC) compared to visual-evoked potentials (VEPs) and standard automated perimetry (SAP) in the detection of early optic nerve damage in patients with multiple sclerosis (MS). Methods: 46 eyes of 23 MS patients were included. Ten of them had a history of acute retrobulbar optic neuritis. A control group of 20 normal subjects was also included. All subjects underwent a complete ophthalmological examination and testing with SAP, GDx VCC and VEPs. Results: 19 eyes (41.3%) were abnormal with GDx VCC compared to 38 eyes (82.6%) with SAP and 31 (64.4%) with VEPs. In the optic neuritis group, 9 eyes (69.2%) had optic nerve pallor; SAP was abnormal in 8 of these eyes (61.5%) while VEPs and GDx VCC were abnormal in 6 eyes (46.1%). 2/20 eyes (10.0%) in the control group gave a false-positive abnormal result with SAP. GDx VCC and VEP were normal for all the eyes in the control group. Conclusions: GDx VCC is less able to detect early defects in MS patients compared to the currently used standard techniques of SAP and VEPs.

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“…Petzold A et al [14] meta-analyzed 12 studies regarding RNFL in eyes with multiple sclerosis optic neuritis (MS ON) [12,[15][16][17][18][19][20][21][22][23][24] . They observed significant average RNFL loss -20.38 µm in MSON eyes (95% CI, -22.86 to -17.91).…”

Section: Discussionmentioning

confidence: 99%

“…They observed significant average RNFL loss -20.38 µm in MSON eyes (95% CI, -22.86 to -17.91). RNFL thickness in eyes affected by ON 59.79 µm-85 µm and in fellow eyes 82.73 µm-99 µm [12,21,[25][26] . In ON without evidence of MS, Costello et al [5] demonstrated RNFL thickness in affected and fellow eyes were 77.5 µm and 99.88 µm, respectively.…”

Section: Discussionmentioning

confidence: 99%

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

Kitthaweesin

Sutra

2013

JBGC

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Background: The majority of optic neuritis patients often notice improvement and gain stability of their visual functions, however, evidences of ongoing retinal nerve fiber layer (RNFL) thinning have been reported. Purposes:To investigate the correlation between RNFL thickness measured with Optical coherence tomography (OCT) and visual function tests and to determine the utility of OCT in visual prognostic assessment of optic neuritis. Method:A prospective study was performed in 12 patients with acute isolated optic neuritis. Best corrected visual acuity (BCVA), Swedish interactive threshold algorithms (SITA) 30-2 strategy on Humphrey field analyzer, and fast RNFL thickness analysis were performed on both affected and fellow eyes at baseline, 1.5, three and six months.Results: Mean BCVA and average mean deviation (MD) of the affected eye were significantly different from the fellow eyes at baseline. Affected eyes had significant thinner of RNFL at baseline, 1.5, three, and six months. Significant correlations between (i) mean RNFL thickness and BCVA at 1.5 (r = 0.707, p = .010), (ii) mean RNFL thickness and MD at 1.5 months (r = 0.674, p = .016) and six months(r = 0.710, p = .032), (iii) mean RNFL thickness at 1.5 months and MD at six months (r = 0.782, p = .013). Conclusion:A correlation between RNFL thickness and visual function tests indicates that OCT might have roles in detection and prediction of RNFL damage in Optic neuritis (ON) patients despite no evidence of MS.

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Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis

Cited by 475 publications

References 38 publications

The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

The Evaluation of the Retinal Nerve Fiber Layer in Multiple Sclerosis with Special-Domain Optical Coherence Tomography

Nerve Fibre Layer Analysis with GDx with a Variable Corneal Compensator in Patients with Multiple Sclerosis

Prognostic determination using optical coherence tomography compared with visual functions in optic neuritis

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