Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

Ong, Yi-Ting; Hilal, Saima; Cheung, Carol Y.; Venketasubramanian, Narayanaswamy; Niessen, Wiro J.; Vrooman, Henri A.; Anuar, Ainur Rahman; Chew, Merwyn; Chen, Christopher; Wong, Tien Yin; Ikram, M. Kamran

doi:10.1016/j.neulet.2014.10.010

Cited by 108 publications

(106 citation statements)

References 28 publications

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“…Therefore, our findings may be relevant to the specific brain changes found in the hippocampus and temporal regions of people in the preclinical stage of AD (40–42). Previous imaging data showing a correlation between RNFL and cerebral volumes in the temporal and occipital lobes are concordant with these findings (43). In addition to RNFL, future studies should explore the ganglion cell-body layer in relationship with cognitive performance and brain alteration.…”

Section: Discussionsupporting

confidence: 80%

Peripapillary Retinal Nerve Fiber Layer Thickness and the Evolution of Cognitive Performance in an Elderly Population

et al. 2017

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Retinal nerve fiber layer (RNFL) thickness is reduced in Alzheimer’s patients. However, whether it is associated with early evolution of cognitive function is unknown. Within 427 participants from the Three-City-Alienor longitudinal population-based cohort, we explored the relationship between peripapillary RNFL thicknesses and the evolution of cognitive performance. RNFL was assessed at baseline by spectral domain optical coherence tomography; cognitive performances were assessed at baseline and at 2 years, with the Mini–Mental State Examination, the Isaacs’ set test, and the Free and Cued Selective Reminding Test (FCSRT). Multivariate linear mixed models were performed. The RNFL was not associated with initial cognitive performance. Nevertheless, a thicker RNFL was significantly associated with a better cognitive evolution over time in the free delayed recall (p = 0.0037) and free + cued delayed recall (p = 0.0043) scores of the FCSRT, particularly in the temporal, superotemporal, and inferotemporal segments. No associations were found with other cognitive tests. The RNFL was associated with changes in scores that assess episodic memory. RNFL thickness could reflect a higher risk of developing cognitive impairment over time.

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Section: Discussionsupporting

confidence: 80%

Peripapillary Retinal Nerve Fiber Layer Thickness and the Evolution of Cognitive Performance in an Elderly Population

et al. 2017

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“…In patients with dementia but without glaucoma, retinal neuronal damage as reflected by thinning of the ganglion cell-inner plexiform layer (GC-IPL) is associated with GM loss in the occipital and temporal lobes. 28 The data consistently respect the topographical relationship between brain involvement and retinal neurodegeneration. 29 We detected regional GMV decrease in the anterior calcarine fissure of advanced POAG but not in early-moderate POAG.…”

Section: Discussionmentioning

confidence: 58%

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Zhang

Wang

Xie

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Likewise, OCT findings in AD suggest the contribution of TRD in the pathophysiology of visual changes. In addition to previous OCT studies showing reduced peripapillary RNFL thickness, a recent SD-OCT study found that reduced grey matter volumes of occipital and temporal lobes was independently associated with thinning of the GC-IPL and peripapillary RNFL in individuals without dementia [69]. Since those cortical regions are an early site of deposition of senile plaques and NFTs, the findings by Y.-T. Ong and coworkers raises the possibility that GC-IPL thinning may reflect neurodegenerative changes in the brain, even before the clinical onset of dementia.…”

Section: Pathological Changes In the Retina And Optic Nervementioning

confidence: 80%

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

Cunha

Moura-Coelho

Proença

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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Alzheimer's disease (AD) is a prevalent, long-term progressive degenerative disorder with great social impact. It is currently thought that, in addition to neurodegeneration, vascular changes also play a role in the pathophysiology of the disease. Visual symptoms are frequent and are an early clinical manifestation; a number of psychophysiologic changes occur in visual function, including visual field defects, abnormal contrast sensitivity, abnormalities in color vision, depth perception deficits, and motion detection abnormalities. These visual changes were initially believed to be solely due to neurodegeneration in the posterior visual pathway. However, evidence from pathology studies in both animal models of AD and humans has demonstrated that neurodegeneration also takes place in the anterior visual pathway, with involvement of the retinal ganglion cells' (RGCs) dendrites, somata, and axons in the optic nerve. These studies additionally showed that patients with AD have changes in retinal and choroidal microvasculature. Pathology findings have been corroborated in in-vivo assessment of the retina and optic nerve head (ONH), as well as the retinal and choroidal vasculature. Optical coherence tomography (OCT) in particular has shown great utility in the assessment of these changes, and it may become a useful tool for early detection and monitoring disease progression in AD. The authors make a review of the current understanding of retinal and choroidal pathological changes in patients with AD, with particular focus on invivo evidence of retinal and choroidal neurodegenerative and microvascular changes using OCT technology.

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Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

Cited by 108 publications

References 28 publications

Peripapillary Retinal Nerve Fiber Layer Thickness and the Evolution of Cognitive Performance in an Elderly Population

Peripapillary Retinal Nerve Fiber Layer Thickness and the Evolution of Cognitive Performance in an Elderly Population

Retinotopic Changes in the Gray Matter Volume and Cerebral Blood Flow in the Primary Visual Cortex of Patients With Primary Open-Angle Glaucoma

Alzheimer’s disease: A review of its visual system neuropathology. Optical coherence tomography—a potential role as a study tool in vivo

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