Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Kumar, Binay; Gupta, Suresh; Nag, Tapas Chandra; Srivastava, Sushma; Saxena, Rohit; Jha, Kumar Abhiram; Srinivasan, B.P.

doi:10.1016/j.exer.2014.06.009

Cited by 143 publications

(112 citation statements)

References 60 publications

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“…Many studies revealed that quercetin could suppress lipopolysaccharide-induced inflammation [20][21][22]. QE also possessed the protective effects on retinal oxidative stress, neuroinflammation and apoptosis in streptozotocin-induced diabetic rats [23]. However, the molecular mechanisms of CCl 4 -induced liver injury and antiinflammatory effects of QE are not yet completely understood.…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 97%

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Xie

et al. 2015

International Immunopharmacology

155

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Section: Contents Lists Available At Sciencedirectmentioning

confidence: 97%

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Xie

et al. 2015

International Immunopharmacology

155

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“…Osmotic Müller cell swelling may also contribute to the development of retinal edema, a major cause of visual detoriation in 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 inflammatory retinal disorders like diabetic retinopathy (Bresnick, 1983;Larsen et al, 2005), by intracellular water accumulation and an impairment of the transglial fluid clearance from the retinal tissue Reichenbach et al, 2007). Experimental diabetic retinopathy is associated with water accumulations within Müller cells and in retinal extracellular spaces (Kumar et al, 2013(Kumar et al, , 2014. Similar water accumulations in Müller cells were found in animal models of retinal hypoxia-ischemia (Stepinac et al, 2005;Kaur et al, 2007).…”

Section: Dysregulation Of Glial Homeostatic Functionsmentioning

confidence: 98%

Purinergic signaling in retinal degeneration and regeneration

Reichenbach

Bringmann

2016

Neuropharmacology

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“…This bioflavonoid has multiple neurobeneficial activities, such as free radical scavenging, antianxiety, neuroprotection, and cognitive enhancing effects. [191][192][193] Quercetin is chemo labile and thermo labile, which leads to lower bioavailability at the target site. 194 In addition, quercetin has poor solubility and distribution, resulting in less bioavailability to the brain.…”

Section: Nanoquercetinmentioning

confidence: 99%

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

Ganesan¹,

Ko²,

Kim³

et al. 2015

IJN

108

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Oxidative stress plays a very critical role in neurodegenerative diseases, such as Parkinson’s disease (PD), which is the second most common neurodegenerative disease among elderly people worldwide. Increasing evidence has suggested that phytobioactive compounds show enhanced benefits in cell and animal models of PD. Curcumin, resveratrol, ginsenosides, quercetin, and catechin are phyto-derived bioactive compounds with important roles in the prevention and treatment of PD. However, in vivo studies suggest that their concentrations are very low to cross blood–brain barrier thereby it limits bioavailability, stability, and dissolution at target sites in the brain. To overcome these problems, nanophytomedicine with the controlled size of 1–100 nm is used to maximize efficiency in the treatment of PD. Nanosizing of phytobioactive compounds enhances the permeability into the brain with maximized efficiency and stability. Several nanodelivery techniques, including solid lipid nanoparticles, nanostructured lipid carriers, nanoliposomes, and nanoniosomes can be used for controlled delivery of nanobioactive compounds to brain. Nanocompounds, such as ginsenosides (19.9 nm) synthesized using a nanoemulsion technique, showed enhanced bioavailability in the rat brain. Here, we discuss the most recent trends and applications in PD, including 1) the role of phytobioactive compounds in reducing oxidative stress and their bioavailability; 2) the role of nanotechnology in reducing oxidative stress during PD; 3) nanodelivery systems; and 4) various nanophytobioactive compounds and their role in PD.

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Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Cited by 143 publications

References 60 publications

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Purinergic signaling in retinal degeneration and regeneration

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

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Retinal neuroprotective effects of quercetin in streptozotocin-induced diabetic rats

Cited by 143 publications

References 60 publications

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway

Purinergic signaling in retinal degeneration and regeneration

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson&rsquo;s disease models

Contact Info

Product

Resources

About

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models