Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration

Priore, Lucian V. Del; Kaplan, Henry J.; Tezel, Tongalp H.; Hayashi, Nobutsugu; Berger, Adam S.; Green, W.Richard

doi:10.1016/s0002-9394(00)00850-3

Cited by 89 publications

(43 citation statements)

References 45 publications

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“…210,[261][262][263][264][265][266] More precise characterization of AMD-induced Bruch membrane ECM abnormalities probably will permit the design of more effective cellular transplantation surgery, which might serve as a treatment for exudative and atrophic AMD. [267][268][269] Neurotrophic agents, which promote neuron survival, might be useful for preserving vision in patients with atrophic and exudative manifestations of AMD. 270 Gene therapy with PEDF might be an example of combined therapy, in which the treatment inhibits CNV growth and promotes photoreceptor survival via a neurotrophic effect (see the "Biochemical Features of CNV Growth" subsection).…”

Section: Implications For Development Of Therapymentioning

confidence: 99%

Current Concepts in the Pathogenesis of Age-Related Macular Degeneration

Zarbin¹

2004

Arch Ophthalmol

916

697

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To review and synthesize information concerning the pathogenesis of age-related macular degeneration (AMD).Methods: Review of the English-language literature.Results: Five concepts relevant to the cell biology of AMD are as follows: (1) AMD involves aging changes plus additional pathological changes (ie, AMD is not just an aging change); (2) in aging and AMD, oxidative stress causes retinal pigment epithelial (RPE) and, possibly, choriocapillaris injury; (3) in AMD (and perhaps in aging), RPE and, possibly, choriocapillaris injury results in a chronic inflammatory response within the Bruch membrane and the choroid; (4) in AMD, RPE and, possibly, choriocapillaris injury and inflammation lead to formation of an abnormal extracellular matrix (ECM), which causes altered diffusion of nutrients to the retina and RPE, possibly precipitating further RPE and retinal damage; and(5) the abnormal ECM results in altered RPE-choriocapillaris behavior leading ultimately to atrophy of the retina, RPE, and choriocapillaris and/or choroidal new vessel growth. In this sequence of events, both the environment and multiple genes can alter a patient's susceptibility to AMD. Implicit in this characterization of AMD pathogenesis is the concept that there is linear progression from one stage of the disease to the next. This assumption may be incorrect, and different biochemical pathways leading to geographic atrophy and/or choroidal new vessels may operate simultaneously.Conclusions: Better knowledge of AMD cell biology will lead to better treatments for AMD at all stages of the disease. Many unanswered questions regarding AMD pathogenesis remain. Multiple animal models and in vitro models of specific aspects of AMD are needed to make rapid progress in developing effective therapies for different stages of the disease.

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Section: Implications For Development Of Therapymentioning

confidence: 99%

Current Concepts in the Pathogenesis of Age-Related Macular Degeneration

Zarbin¹

2004

Arch Ophthalmol

916

697

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“…In a pilot study, AMD patients receiving adult human RPE underwent immune suppression with prednisone, cyclosporine, and azathiaprine, and the grafts did not appear to be rejected . Histopathology of one of these patients 114 days after transplantation showed no evidence of transplant rejection (Del Priore et al, 2001). However, these elderly patients were not able to tolerate systemic triple therapy for an extended period of time.…”

Section: Introductionmentioning

confidence: 91%

Early Attachment of Uncultured Retinal Pigment Epithelium from Aged Donors onto Bruch's Membrane Explants

Tsukahara¹,

Ninomiya²,

Castellarin³

et al. 2002

Experimental Eye Research

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“…72 However, in the majority of trials, long-term improvement in visual acuity was not reproduced, and fibrosis formed in the grafts due to immune rejection. 71 Immunosuppression improved the outcome of transplantation, 70,73 although in the long run these drugs lead to systematic side effects. 73 To avoid rejection, autologous RPE grafts were instead used.…”

Section: Rpe Cell Replacementmentioning

confidence: 99%

“…71 Immunosuppression improved the outcome of transplantation, 70,73 although in the long run these drugs lead to systematic side effects. 73 To avoid rejection, autologous RPE grafts were instead used. 74,75 RPE, harvested from the nasal subretinal region, was dissociated and transplanted around the macular region.…”

Section: Rpe Cell Replacementmentioning

confidence: 99%

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement

Foggia

Makwana

Ali³

et al. 2016

Journal of Ocular Pharmacology and Therapeutics

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Stem cell therapies are being explored as potential treatments for retinal disease. How to replace neurons in a degenerated retina presents a continued challenge for the regenerative medicine field that, if achieved, could restore sight. The major issues are: (i) the source and availability of donor cells for transplantation; (ii) the differentiation of stem cells into the required retinal cells; and (iii) the delivery, integration, functionality, and survival of new cells in the host neural network. This review considers the use of induced pluripotent stem cells (iPSC), currently under intense investigation, as a platform for cell transplantation therapy. Moreover, patientspecific iPSC are being developed for autologous cell transplantation and as a tool for modeling specific retinal diseases, testing gene therapies, and drug screening.

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Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration

Cited by 89 publications

References 45 publications

Current Concepts in the Pathogenesis of Age-Related Macular Degeneration

Current Concepts in the Pathogenesis of Age-Related Macular Degeneration

Early Attachment of Uncultured Retinal Pigment Epithelium from Aged Donors onto Bruch's Membrane Explants

Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement

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