Retinal safety of the irradiation delivered to light-adjustable intraocular lenses evaluated in a rabbit model

Werner, Liliana; Chang, Wellington; Haymore, Jonathan; Haugen, Brian; Romaniv, Natalya; Sandstedt, Christian A.; Chang, Song; Mamalis, Nick

doi:10.1016/j.jcrs.2010.02.018

Cited by 18 publications

(11 citation statements)

References 19 publications

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“…However, the use of larger animals, like rabbits, offers the advantage of having bigger eyes that enable the insertion of IOLs and studying the effect of this surgery in the retina as well as the possible effect of blocking blue and other visible light sources [22]. …”

Section: Discussionmentioning

confidence: 99%

“…We used rabbits given that they are more accessible, easier to handle than pigs or nonhuman primates, and their eye size allows performing therapeutic or surgical procedures such as the insertion of IOLs with protective filters [22]. Although studies in rabbits have shown histological changes and dysfunction of the RPE after light exposure [1, 23], photochemical retinal damage in rabbits has not been fully described.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits

Viteri

Heras-Mulero

Fernández-Robredo

et al. 2014

Oxidative Medicine and Cellular Longevity

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Photochemical damage occurs after an exposure to high energy radiation within the visible spectrum of light, causing morphological changes in the retina and the formation of superoxide anion. In this study we created a model of phototoxicity in rabbits. Animals were exposed to a light source for 120 minutes and were sacrificed immediately or one week after exposure. Outer nuclear layer and neurosensory retina thickness measurements and photoreceptor counting were performed. Caspase-1 and caspase-3 were assessed by immunohistochemistry. Dihydroethidium was used to evaluate in situ generation of superoxide and thiobarbituric acid reactive substances were measured in retinal homogenates as indicators of lipid peroxidation. The total antioxidant capacity and oxidative ratio were also determined. Retinas from rabbits exposed to light showed higher levels of lipid peroxidation than the unexposed animals and a decrease in outer nuclear layer and neurosensory retina thickness. Our study demonstrates that light damage produces an increase in retinal oxidative stress immediately after light exposure that decreases one week after exposure. However, some morphological alterations appear days after light exposure including apoptotic phenomena. This model may be useful in the future to study the protective effect of antioxidant substances or new intraocular lenses with yellow filters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits

Viteri

Heras-Mulero

Fernández-Robredo

et al. 2014

Oxidative Medicine and Cellular Longevity

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“…However, once it is locked in, it is permanent. Multiple trials have established the safety of this lens in humans, with long-term postoperative stability and low rate of complications, as well as the lack of harm on the cornea and retina in animal models exposed to the UV light adjustment 41, 42,43, 44,45 . As a result, the light adjustable lens is currently undergoing phase 3 FDA trials in the US, and is already available in Europe and Mexico.…”

Section: Five-year Viewmentioning

confidence: 99%

Evaluating the evidence for and against the use of IOLs in infants and young children

Kumar

Lambert

2016

Expert Review of Medical Devices

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Summary Congenital cataracts account for 5–20% of childhood blindness worldwide. In the US, the prevalence of visually significant infantile cataracts is anywhere from 3–4 per 10,000 live births. Infantile cataracts need to be removed early in life in order to prevent the onset of deprivation amblyopia. As a result, cataract surgery is usually performed between age 4–8 weeks depending on the laterality and severity of the cataract. Given advances in the field, pediatric cataract surgery is now a safe and effective intervention for infants, but good visual outcomes require occlusion therapy and optical correction. This review will address current perspectives on the use of intraocular lenses to optically correct infants and young children after cataract surgery, as well as novel designs for intraocular lenses and directions for future research.

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“…As a result, precursors will diffuse to the middle of the lens, increasing both the lens's radius of curvature and power. The safety of this technique was proven by Werner et al in rabbits . In their work, the researchers exposed the rabbits' retinas to UV light for a duration five times longer than that required for the lens to adjust, and no detrimental effect on the tissue was observed.…”

Section: Physical Phenomenamentioning

confidence: 99%

In Situ Generated Medical Devices

Cohn

Sloutski

Elyashiv

et al. 2019

Adv Healthcare Materials

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Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.

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Retinal safety of the irradiation delivered to light-adjustable intraocular lenses evaluated in a rabbit model

Abstract: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosures are found in the footnotes.

Cited by 18 publications

References 19 publications

Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits

Oxidative Stress and Histological Changes in a Model of Retinal Phototoxicity in Rabbits

Evaluating the evidence for and against the use of IOLs in infants and young children

In Situ Generated Medical Devices

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