Retinal toxicity associated with cisplatin and etoposide in pediatric patients

Hilliard, Lee; Berkow, Roger L.; Watterson, Jan; Ballard, Evan A.; Balzer, Gene K.; Moertel, Christopher L.

doi:10.1002/(sici)1096-911x(199704)28:4<310::aid-mpo12>3.0.co;2-g

Cited by 37 publications

(16 citation statements)

References 15 publications

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“…Visual loss secondary to retinopathy occurs with the use of cisplatin. [28][29][30][31] Visual loss may be bilateral and irreversible and visual fields shows bilateral central scotomas. 29 Visual evoked response and electroretinogram have been used to document the retinotoxicity of cisplatin and etoposide.…”

Section: Posterior Segment Side Effectsmentioning

confidence: 99%

“…29 Visual evoked response and electroretinogram have been used to document the retinotoxicity of cisplatin and etoposide. 30 Electroretinogram showed a markedly reduced awave amplitude and absent b-waves. 29 Autopsy showed splitting of the plexiform layer consistent with the loss of the electroretinogram b-wave.…”

Section: Posterior Segment Side Effectsmentioning

confidence: 99%

“…39 The mechanism of visual toxicity induced by cisplatin is unknown but may result from central nervous system accumulation of drug after repeated doses, especially with high-dose platinum containing regimens. 30 Toxic neuropathies including disc oedema, retinal oedema and optic neuritis are rare, but have been described as occasional side effects of treatment with cisplatin. 40 Tamoxifen has been reported to cause bilateral optic neuritis followed by optic atrophy and visual loss.…”

Section: Neuro-ophthalmic Side Effectsmentioning

confidence: 99%

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Toxicidad ocular de la quimioterapia sistémica anticancerosa

Omoti

2006

Pharmacy pract. (Granada Ed. impr.)

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*The increased use of chemotherapeutic agents has resulted in longer cancer patient survival. Consequently the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Ocular toxicity induced by cancer chemotherapy includes a broad spectrum of disorders, reflecting the unique anatomical, physiological and biochemical features of the eye. Understanding the ocular side effects will assist the ophthalmologist and oncologist to recognize them early and intervene before blindness occurs. Anticipation of various treatmentrelated toxicities may also provide the opportunity for pharmacists to develop intervention strategies that could minimize or eliminate an expected side effect. The ophthalmologist should examine patients on anticancer therapy at baseline and three monthly thereafter. The various ocular side effects of anticancer chemotherapeutic agents, tamoxifen, and interferon on the adnexia, anterior segment, posterior segment and neuro-ophthalmic structures were reviewed.

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Section: Posterior Segment Side Effectsmentioning

confidence: 99%

Section: Posterior Segment Side Effectsmentioning

confidence: 99%

Section: Neuro-ophthalmic Side Effectsmentioning

confidence: 99%

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Toxicidad ocular de la quimioterapia sistémica anticancerosa

Omoti

2006

Pharmacy pract. (Granada Ed. impr.)

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“…There have also been reports of retinal toxicity with electroretinography and visual evoked potential abnormalities after cisplatin treatment. 26,27 It might be speculated that the presence of visual evoked potential abnormalities might hint to vulnerability for a certain drug. Antiepileptic vigabatrin induces retinopathy.…”

Section: Discussionmentioning

confidence: 99%

Electroretinography and Visual Evoked Potentials in Childhood Brain Tumor Survivors

et al. 2016

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This population-based cross-sectional study evaluates the clinical value of electroretinography and visual evoked potentials in childhood brain tumor survivors. A flash electroretinography and a checkerboard reversal pattern visual evoked potential (or alternatively a flash visual evoked potential) were done for 51 survivors (age 3.8-28.7 years) after a mean follow-up time of 7.6 (1.5-15.1) years. Abnormal electroretinography was obtained in 1 case, bilaterally delayed abnormal visual evoked potentials in 22/51 (43%) cases. Nine of 25 patients with infratentorial tumor location, and altogether 12 out of 31 (39%) patients who did not have tumors involving the visual pathways, had abnormal visual evoked potentials. Abnormal electroretinographies are rarely observed, but abnormal visual evoked potentials are common even without evident anatomic lesions in the visual pathway. Bilateral changes suggest a general and possibly multifactorial toxic/adverse effect on the visual pathway. Electroretinography and visual evoked potential may have clinical and scientific value while evaluating long-term effects of childhood brain tumors and tumor treatment.

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“…Most of the patients have shown ocular toxicities within 2–14 weeks of therapy. Ocular complications include vitreous opacification along with nonspecific blurred vision, corneal edema and opacities, internal ophthalmoplegia, optic neuritis, blindness with optic atrophy, and exudative retinopathy with exudates and hemorrhage [105,106]. …”

Section: Vitreous Opacificationmentioning

confidence: 99%

Ocular toxicity from systemically administered xenobiotics

Gokulgandhi

Vadlapudi

Mitra

2012

Expert Opinion on Drug Metabolism & Toxicology

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Introduction The eye is considered as the most privileged organ because of the blood–ocular barrier that acts as a barrier to systemically administered xenobiotics. However, there has been a significant increase in the number of reports on systemic drug-induced ocular complications. If such complications are left untreated, then it may cause permanent damage to vision. Hence, knowledge of most recent updates on ever-increasing reports of such toxicities has become imperative to develop better therapy while minimizing toxicities. Areas covered The article is mainly divided into anterior and posterior segment manifestations caused by systemically administered drugs. The anterior segment is further elaborated on corneal complications where as the posterior segment is focused on optic nerve, retinal and vitreous complications. Furthermore, this article includes recent updates on acute and chronic ocular predicaments, in addition to discussing various associated symptoms caused by drugs. Expert opinion Direct correlation of ocular toxicities due to systemic drug therapy is evident from current literature. Therefore, it is necessary to have detailed documentation of these complications to improve understanding and predict toxicities. We made an attempt to ensure that the reader is aware of the characteristic ocular complications, the potential for irreversible drug toxicity and indications for cessation.

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Retinal toxicity associated with cisplatin and etoposide in pediatric patients

Cited by 37 publications

References 15 publications

Toxicidad ocular de la quimioterapia sistémica anticancerosa

Toxicidad ocular de la quimioterapia sistémica anticancerosa

Electroretinography and Visual Evoked Potentials in Childhood Brain Tumor Survivors

Ocular toxicity from systemically administered xenobiotics

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