Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations

Wang, Jie Jin; Liew, Gerald; Klein, Ronald; Rochtchina, Elena; Knudtson, Michael D.; Klein, Barbara E. K.; Wong, Tien Yin; Burlutsky, George; Mitchell, Paul

doi:10.1093/eurheartj/ehm221

Cited by 311 publications

(250 citation statements)

References 49 publications

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“…There are many different methods to calculate change point (cut point) such as using determined change point value in previous studies, using sample quantile like median. Other methods that are worth mentioning are optimized change point (Buettner et al, 1997), p-value minimization (Heinzl and Tempfer, 2001), and change point models (Wang et al, 2007). Multiple studies were conducted to determine cut point using change point models.…”

Section: Introductionmentioning

confidence: 99%

Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Abdollahi

Hajizadeh²,

Baghestani³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Section: Introductionmentioning

confidence: 99%

Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Abdollahi

Hajizadeh²,

Baghestani³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…No differences in retinal microvasculature was observed between undiagnosed versus previously diagnosed cohorts, which is somewhat unsurprising, given that changes to the retinal microvascular structure are generally considered to be early biomarkers of systemic microvascular damage (28)(29)(30). It is likely that the present study did not have adequate statistical power to detect any modest associations between diabetes status and retinal vessel caliber changes.…”

Section: Discussionmentioning

confidence: 64%

Severity of coronary artery disease and retinal microvascular signs in patients with diagnosed versus undiagnosed diabetes: cross-sectional study

et al. 2016

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Background: There is increasing evidence that a considerable proportion of patients with diabetes remain undiagnosed and untreated, however, it is unclear whether this is associated with more severe coronary artery disease (CAD) and microvasculature changes compared with diagnosed patients. We assessed CAD extent and severity, along with changes to the retinal microvascular structure in participants with undiagnosed versus diagnosed type 2 diabetes. Methods: Participants of the Australian Heart Eye Study were stratified into participants with previously diagnosed diabetes (n=489), undiagnosed diabetes (n=76) and no diabetes (n=1,112). Retinal vessel caliber was measured from digital retinal images. Extent and severity of CAD was assessed using Extent and Gensini scores from angiography findings, respectively.Results: Participants with undiagnosed and diagnosed diabetes versus those with no diabetes (reference group) had increased odds of being in the highest quartile of Gensini scores, multivariate adjusted odds ratios (OR) =7.02 [95% confidence interval (CI), 2.04-24.1] and OR =2.76 (95% CI, 1.67-4.55), respectively.Participants with undiagnosed and diagnosed diabetes versus those with no diabetes also had increased odds of being in the highest quartile of Extent scores, multivariate adjusted OR =7.63 (95% CI, 2.15-27.10) and OR =3.72 (95% CI, 2.22-6.27), respectively. No significant differences were observed in retinal vessel caliber between participants with undiagnosed versus diagnosed diabetes.Conclusions: The present study demonstrated that participants with undiagnosed diabetes compared to those with previously diagnosed diabetes, had a stronger likelihood of having more severe and extensive CAD. However, retinal microvascular signs did not differ by diabetes status.

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“…This association between ocular circulation and systemic cardiovascular disease has been extensively studied, with changes in retinal vessel diameters having been shown to predict risk for coronary heart disease, stroke and stroke mortality (Wong, 2001) (Wong, 2002). Pooled data from the Beaver Dam Eye Study and the Blue Mountains Eye Study also show that smaller arterial diameters and larger retinal venous diameters are associated with increased risk for stroke mortality (Wang, 2007). As glaucoma patients also have similar disturbances in retinal arterial diameter (Jonas, 1989), there is clear reasoning for associating glaucoma with cardiovascular dysfunction.…”

Section: Altered Blood Flow As a Risk Factor For Glaucoma (Progression)mentioning

confidence: 99%

A Vascular Approach to Glaucoma

Pinto¹,

Stalmans²

2011

Glaucoma - Basic and Clinical Concepts

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Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations

Abstract: Retinal vessel diameter may predict risk of CHD and stroke deaths in middle-aged persons.

Cited by 311 publications

References 49 publications

Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Determination of a Change Point in the Age at Diagnosis of Breast Cancer Using a Survival Model

Severity of coronary artery disease and retinal microvascular signs in patients with diagnosed versus undiagnosed diabetes: cross-sectional study

A Vascular Approach to Glaucoma

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