Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression

Noman, Abu Shadat Mohammod; Koide, Naoki; Iftakhar-E-Khuda, Imtiaz; Dagvadorj, Jargalsaikhan; Tumurkhuu, Gantsetseg; Naiki, Yoshikazu; Komatsu, Takayuki; Yoshida, Tomoaki; Yokochi, Takashi

doi:10.1016/j.imlet.2010.04.006

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…Because cancer undergoes metastasis and spreads to other organs at late stages, we speculated that RIZ1 might play an important role in tumor metastasis, although increases in mRNA expression do not always translate proportionally into protein expression levels. Our speculation was in line with two previous observations 23, 24.…”

Section: Resultssupporting

confidence: 93%

“…The second observation was that RIZ1 may augment the expression of nuclear factor of activated T cell 1 (NFATc1) 24, which induces breast cancer cell invasion via cyclooxygenase-2 29. Therefore, we hypothesize that RIZ1 might possess dual functions during tumor progression, acting as a tumor suppressor to induce apoptosis in the early stages and a tumor promoter to induce metastasis in late stages.…”

Section: Resultsmentioning

confidence: 99%

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Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Sun¹,

Liao²,

Liu³

et al. 2011

Int. J. Med. Sci.

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Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.

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Section: Resultssupporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Sun¹,

Liao²,

Liu³

et al. 2011

Int. J. Med. Sci.

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“…TRAP staining was carried out according to the manufacturer's instruction as described elsewhere [23]. The images were taken with a digital camera attached to the microscope.…”

Section: Trap Stainingmentioning

confidence: 99%

Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ)

et al. 2012

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“…Retinoblastoma protein-interacting zinc finger 1 (RIZ1) protein also participates in RANKLinduced osteoclastogenesis, [114] binding with both retinoblastoma protein and estrogen receptors and reportedly involved in osteosarcoma. [115][116][117] RIZ1 expression increases under RANKL induction at 24 hours, and RIZ1 siRNA-transfected RAW 264.7 cells showed significantly inhibited NFATc1 activation 3 days post-RANKL and M-CSF treatment, but with no significant influence on TRAF6 expression.…”

Section: Osteoclastogenesismentioning

confidence: 99%

RNA therapeutics targeting osteoclast-mediated excessive bone resorption

Wang

Grainger

2012

Advanced Drug Delivery Reviews

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RNA interference (RNAi) is a sequence-specific post-transcriptional gene silencing technique developed with dramatically increasing utility for both scientific and therapeutic purposes. Short interfering RNA (siRNA) is currently exploited to regulate protein expression relevant to many therapeutic applications, and commonly used as a tool for elucidating disease-associated genes. Osteoporosis and their associated osteoporotic fragility fractures in both men and women are rapidly becoming a global healthcare crisis as average life expectancy increases worldwide. New therapeutics are needed for this increasing patient population. This review describes the diversity of molecular targets suitable for RNAi-based gene knock-down in osteoclasts to control osteoclast-mediated excessive bone resorption. We identify strategies for developing targeted siRNA delivery and efficient gene silencing, and describe opportunities and challenges of introducing siRNA as a therapeutic approach to hard and connective tissue disorders.

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Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression

Cited by 10 publications

References 30 publications

Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1

Inhibition of receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast formation by pyrroloquinoline quinine (PQQ)

RNA therapeutics targeting osteoclast-mediated excessive bone resorption

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