Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

Guzman, Frederick; Fazeli, Yasamin; Khuu, Meagan; Salcido, Kelsey; Singh, Sarah

doi:10.3390/cancers12102807

Cited by 32 publications

(39 citation statements)

References 108 publications

(157 reference statements)

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“…RB homologs in animals and plants actively repress transcription by interacting with and recruiting chromatin modifying enzymes to the promoters of E2F target genes [ 13 , 17 , 27 , 35 , 36 ]. Several of these chromatin modifying enzymes contain a LxCxE amino acid motif that binds to a conserved cleft in the RB pocket domain and allows RB to bind both the chromatin modifiers and E2F factors simultaneously [ 37 ].…”

Section: Evolutionary History Of E2f and Rb Homologs In Eukaryotesmentioning

confidence: 99%

Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?

Swarnalatha

Dennehey

Johnson

2021

Cancers

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Members of the E2F transcription factor family regulate the expression of genes important for DNA replication and mitotic cell division in most eukaryotes. Homologs of the retinoblastoma (RB) tumor suppressor inhibit the activity of E2F factors, thus controlling cell cycle progression. Organisms such as budding and fission yeast have lost genes encoding E2F and RB, but have gained genes encoding other proteins that take on E2F and RB cell cycle-related functions. In addition to regulating cell proliferation, E2F and RB homologs have non-canonical functions outside the mitotic cell cycle in a variety of eukaryotes. For example, in both mammals and plants, E2F and RB homologs localize to DNA double-strand breaks (DSBs) and directly promote repair by homologous recombination (HR). Here, we discuss the parallels between mammalian E2F1 and RB and their Arabidopsis homologs, E2FA and RB-related (RBR), with respect to their recruitment to sites of DNA damage and how they help recruit repair factors important for DNA end resection. We also explore the question of whether this role in DNA repair is a conserved ancient function of the E2F and RB homologs in the last eukaryotic common ancestor or whether this function evolved independently in mammals and plants.

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Section: Evolutionary History Of E2f and Rb Homologs In Eukaryotesmentioning

confidence: 99%

Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?

Swarnalatha

Dennehey

Johnson

2021

Cancers

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“…10 RB1 has also been shown to maintain chromatin structure and regulate chromatin remodeling complexes. 11 Chromatin remodeling is a vital mechanism in which modifications are made to the chromatin structure in order for transcription and gene expression to take place. BAP1 is a gene whose product is involved in chromatin remodeling by removing ubiquitin molecules from histones and has been reported to be altered in various malignancies, including melanoma, mesothelioma, breast, and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

“…This mutation is located in RB C‐terminal domain, which is required for high‐affinity binding of E2F transcription factors, leading to negative regulation of cell cycle progression and cell growth suppression 10 . RB1 has also been shown to maintain chromatin structure and regulate chromatin remodeling complexes 11 …”

Section: Discussionmentioning

confidence: 99%

Genetic profile of primary mucinous cystadenocarcinoma of the breast—A case report

et al. 2021

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Primary mucinous cystadenocarcinoma of the breast is a rare neoplasm with few reports in the literature. Here, we report for the first time a comprehensive genetic profile of a primary mucinous cystadenocarcinoma of the breast, using next-generation sequencing 580 cancer-associated gene panel. Mutations in TP53, RB1, and BAP1 were identified. The findings suggest that this tumor is driven mostly by abnormalities in tumor suppressor genes, primarily involved in cell cycle control and chromatin remodeling. Molecular characterization of additional primary mucinous cystadenocarcinomas of the breast is warranted and might provide information related to its biology and behavior.

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“…Moreover, the occurrence and further progression of RB requires additional epigenetic dysregulation, following the inactivation of the RB1 protein, which manifests as the disruption of multiple signaling pathways in the tumor cells ( 24 ). The epigenetic dysregulation in RB includes abnormal histone modifications, DNA methylation or acetylation and non-coding RNAs ( 25 ). With regards to non-coding RNAs, aberrant non-coding RNA expression in RB tumorigenesis and progression has been reported ( 21 , 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Roles of the microRNA‑338‑3p/NOVA1 axis in retinoblastoma

Sun

Wang

et al. 2021

Mol Med Rep

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Retinoblastoma (RB) is an intraocular malignancy that mainly affects young children. Previous reports have demonstrated that mutations or the inactivation of the RB1 gene were the main cause of RB; however, disruption of the intracellular signaling pathways following deficiency of RB1 requires further investigation. Based on the Gene Expression Omnibus data and bioinformatics prediction, the present study aimed to investigate the microRNA (miR)-338-3p/neuro-oncological ventral antigen 1 (NOVA1) axis in RB. Subsequently, overexpression and knockdown of miR-338-3p and NOVA1, respectively, were performed to study the role of miR-338-3p/NOVA1 in the progression of the RB cells. The results demonstrated that overexpression of miR-338-3p significantly inhibited cell proliferation, migration and invasion, and promoted apoptosis of the RB cells. Moreover, knockdown of NOVA1 showed similar results. A dual-luciferase reporter assay and rescue experiments further confirmed the direct binding between miR-338-3p and NOVA1. Taken together, the results indicated that miR-338-3p acted as tumor suppressor by targeting the oncogene of NOVA1 in RB, which may serve as potential therapeutic targets in RB.

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Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

Cited by 32 publications

References 108 publications

Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?

Direct Regulation of DNA Repair by E2F and RB in Mammals and Plants: Core Function or Convergent Evolution?

Genetic profile of primary mucinous cystadenocarcinoma of the breast—A case report

Roles of the microRNA‑338‑3p/NOVA1 axis in retinoblastoma

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