Retinohypothalamic projections in the hamster and rat demonstrated using cholera toxin

Johnson, Ralph F.; Morin, L.P.; Moore, Robert Y.

doi:10.1016/0006-8993(88)90558-6

Cited by 414 publications

(239 citation statements)

References 29 publications

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“…In all species, only some SCN cells receive direct retinal input, with species differences in RHT termination sites. In rats, most retinal input terminates in the ventral region, with little or no retinal input to the dorsomedial SCN (Moore, 1996), whereas in hamsters, retinal input is concentrated in the ventrolateral aspect of the SCN (Johnson et al, 1988). RHT input to the mouse SCN is very dense in the ventral and lateral aspects of the nucleus and sparse in the dorsal and medial regions (Abrahamson and Moore, 2001) (Figs.…”

Section: Discussionmentioning

confidence: 99%

Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus

et al. 2004

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“…The cells in question likely correspond to a type of glia cells that give rise to the retinohypothalamic tract (RHT), which is the relevant eye-SCN connection for circadian entrainment. In addition, the RHT projects to the SPC (Johnson et al, 1988), leading to the attractive speculation that masking is mediated by direct light-signaling via TGF-␣ or EGF to the EGFR in the SPC (Kramer et al, 2001). This is a very nice model, explaining both clock-regulated control of behavior via TGF-␣ release in the SCN and direct regulation by light through a connection from the eye to the SPC (Fig.…”

Section: Neuropeptides and Growth Factors Rhythmicallymentioning

confidence: 99%

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

2002

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ABSTRACT:The fruit fly, Drosophila melanogaster, has been a grateful object for circadian rhythm researchers over several decades. Behavioral, genetic, and molecular studies helped to reveal the genetic bases of circadian time keeping and rhythmic behaviors. Contrary, mammalian rhythm research until recently was mainly restricted to descriptive and physiologic approaches. As in many other areas of research, the surprising similarity of basic biologic principles between the little fly and our own species, boosted the progress of unraveling the genetic foundation of mammalian clock mechanisms. Once more, not only the basic mechanisms, but also the molecules involved in establishing our circadian system are taken or adapted from the fly. This review will try to give a comparative overview about the two systems, highlighting similarities as well as specifics of both insect and murine clocks.

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“…The retinohypothalamic tract conveys photic information to the SCN, entraining the circadian pacemaker to the 24 h environmental cycle (Moore, 1973;Daan and Pittendrigh, 1976). Photic cues are the most important entraining signals, and it is well established that the greatest density of retinal fibers travel to an area of the SCN referred to as the ventrolateral region and are more sparse in the area called the dorsomedial region (Johnson et al, 1988;Moga and Moore, 1997;Muscat et al, 2003). These studies and others indicate that SCN cells are neither functionally nor regionally homogeneous (Hamada et al, 2001;Nakamura et al, 2001;Quintero et al, 2003;Schaap et al, 2003;Yamaguchi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Differential Response of Period 1 Expression within the Suprachiasmatic Nucleus

Nakamura¹

2005

Journal of Neuroscience

109

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The suprachiasmatic nuclei (SCNs) of the hypothalamus contain a circadian clock that exerts profound control over rhythmic physiology and behavior. The clock consists of multiple autonomous cellular pacemakers distributed throughout the rat SCN. In response to a shift in the light schedule, the SCN rapidly changes phase to achieve the appropriate phase relationship with the shifted light schedule. Through use of a transgenic rat in which rhythmicity in transcription of the Period 1 gene was measured with a luciferase reporter (Per1-luc), we have been successful in tracking the time course of molecular rhythm phase readjustments in different regions of the SCN that occur in response to a shift in the light schedule. We find that different regions of the SCN phase adjust at different rates, leading to transient internal desynchrony in Per1-luc expression among SCN regions. This desynchrony among regions is most pronounced and prolonged when the light schedule is advanced compared with light schedule delays. A similar asymmetry in the speed of phase resetting is observed with locomotor behavior, suggesting that phase shifting kinetics within the SCN may underlay the differences observed in behavioral resetting to advances or delays in the light schedule.

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Retinohypothalamic projections in the hamster and rat demonstrated using cholera toxin

Cited by 414 publications

References 29 publications

Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus

Phenotype Matters: Identification of Light-Responsive Cells in the Mouse Suprachiasmatic Nucleus

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

Differential Response of Period 1 Expression within the Suprachiasmatic Nucleus

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