Retinoic acid influences the development of the inferior olivary nucleus in the rodent

Yamamoto, Miyuki; Fujinuma, Masahiro; Hirano, Shinji; Hayakawa, Yukihiro; Clagett‐Dame, Margaret; Zhang, Jinghua; McCaffery, Peter

doi:10.1016/j.ydbio.2005.02.007

Cited by 29 publications

(12 citation statements)

References 56 publications

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“…The expression is nonuniform, and is particularly high in areas overlying the rhombic lip, from which late-derived neuron populations of the precerebellar system (pontine nuclei, inferior olive) originate. This correlates with retinoiddependent regulation of cell proliferation and fate and later anatomical organization in these structures (Yamamoto et al, 1999(Yamamoto et al, , 2005, and with late teratogenic effects of excess retinoids on the same structures in human embryos (Lammer and Armstrong, 1992). Another potential source of RA at late stages is the auditory afferents.…”

Section: Later Synthetic Sourcesmentioning

confidence: 90%

Retinoic acid and hindbrain patterning

2006

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Retinoid signaling plays an important role in the developmental patterning of the hindbrain. Studies of the teratogenic effects of retinoids showed early on that the hindbrain suffered patterning defects in cases of retinoid excess or deficiency. Closer examination of these effects in animal models suggested that retinoids might play a physiological role in specifying the antero-posterior axis of the hindbrain. This idea was supported by the localization of retinoid synthetic and degradative enzymes, binding proteins, and receptors to the hindbrain and neighboring regions of the neuroepithelium and the mesoderm. In parallel, it became clear that the molecular patterning of the hindbrain, in terms of the regionalized expression of Hox genes and other developmental regulatory genes, is profoundly influenced by retinoid signaling.

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Section: Later Synthetic Sourcesmentioning

confidence: 90%

Retinoic acid and hindbrain patterning

2006

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“…Therefore, the SDF1/CXCR4 signaling pathway might either have an instructive role ( Sdf1 has higher expression levels anteriorly) and/or modulate the responsiveness of pontine neurons to other anterior guidance cues such as Netrins and Slits. Similarly, retinoic acid (RA) is also released from the meninges and increased RA levels have been suggested to induce defasciculation of the migratory stream and posterior ectopic migration (Yamamoto et al, 2003, 2005). However, due to the extensive effects of varying RA levels on several developmental processes, direct roles in PN guidance are difficult to pinpoint.…”

Section: Molecular Mechanisms Controlling the Migration Of Pontine Numentioning

confidence: 99%

The Long Journey of Pontine Nuclei Neurons: From Rhombic Lip to Cortico-Ponto-Cerebellar Circuitry

Kratochwil

Maheshwari

Rijli

2017

Front. Neural Circuits

113

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The pontine nuclei (PN) are the largest of the precerebellar nuclei, neuronal assemblies in the hindbrain providing principal input to the cerebellum. The PN are predominantly innervated by the cerebral cortex and project as mossy fibers to the cerebellar hemispheres. Here, we comprehensively review the development of the PN from specification to migration, nucleogenesis and circuit formation. PN neurons originate at the posterior rhombic lip and migrate tangentially crossing several rhombomere derived territories to reach their final position in ventral part of the pons. The developing PN provide a classical example of tangential neuronal migration and a study system for understanding its molecular underpinnings. We anticipate that understanding the mechanisms of PN migration and assembly will also permit a deeper understanding of the molecular and cellular basis of cortico-cerebellar circuit formation and function.

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“…McCaffery’s group found that RA is produced by RALDH2 in the meninges overlying the hindbrain at mouse embryonic day 13, and that RA activity as assessed by RARE-lacZ is present in precerebellar neurons migrating around the hindbrain circumference to form the inferior olive and pontine nuclei [182]. This group went on to show that RA is required for the generation of posterior neurons in the inferior olive, as the posterior inferior olive is significantly smaller in late VAD rat embryos compared to vitamin A-sufficient controls [183]. In the meninges covering the cortex, levels of Raldh2 increase in the mouse embryo from E13 to E14 onward, to a maximal level in the newborn brain [184].…”

Section: Vitamin a And Embryonic Developmentmentioning

confidence: 99%

Vitamin A in Reproduction and Development

2011

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The requirement for vitamin A in reproduction was first recognized in the early 1900’s, and its importance in the eyes of developing embryos was realized shortly after. A greater understanding of the large number of developmental processes that require vitamin A emerged first from nutritional deficiency studies in rat embryos, and later from genetic studies in mice. It is now generally believed that all-trans retinoic acid (RA) is the form of vitamin A that supports both male and female reproduction as well as embryonic development. This conclusion is based on the ability to reverse most reproductive and developmental blocks found in vitamin A deficiency induced either by nutritional or genetic means with RA, and the ability to recapitulate the majority of embryonic defects in retinoic acid receptor compound null mutants. The activity of the catabolic CYP26 enzymes in determining what tissues have access to RA has emerged as a key regulatory mechanism, and helps to explain why exogenous RA can rescue many vitamin A deficiency defects. In severely vitamin A-deficient (VAD) female rats, reproduction fails prior to implantation, whereas in VAD pregnant rats given small amounts of carotene or supported on limiting quantities of RA early in organogenesis, embryos form but show a collection of defects called the vitamin A deficiency syndrome or late vitamin A deficiency. Vitamin A is also essential for the maintenance of the male genital tract and spermatogenesis. Recent studies show that vitamin A participates in a signaling mechanism to initiate meiosis in the female gonad during embryogenesis, and in the male gonad postnatally. Both nutritional and genetic approaches are being used to elucidate the vitamin A-dependent pathways upon which these processes depend.

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Retinoic acid influences the development of the inferior olivary nucleus in the rodent

Cited by 29 publications

References 56 publications

Retinoic acid and hindbrain patterning

Retinoic acid and hindbrain patterning

The Long Journey of Pontine Nuclei Neurons: From Rhombic Lip to Cortico-Ponto-Cerebellar Circuitry

Vitamin A in Reproduction and Development

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