2004
DOI: 10.1038/sj.onc.1208104
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Retinoic acid mediates degradation of IRS-1 by the ubiquitin–proteasome pathway, via a PKC-dependant mechanism

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Cited by 58 publications
(29 citation statements)
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“…IRS-1 per se is also known to be a strong mitogen and to inhibit differentiation (3)(4)(5). Downregulation of IRS-1 (by either antisense or small interfering RNA) abrogates the transformed phenotype (6)(7)(8). IRS-1 plays a major role in the regulation of cell size (2,4,37), and deletion of IRS-1 genes in mice (38) or Drosophila (39) causes a 50% reduction in body size.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…IRS-1 per se is also known to be a strong mitogen and to inhibit differentiation (3)(4)(5). Downregulation of IRS-1 (by either antisense or small interfering RNA) abrogates the transformed phenotype (6)(7)(8). IRS-1 plays a major role in the regulation of cell size (2,4,37), and deletion of IRS-1 genes in mice (38) or Drosophila (39) causes a 50% reduction in body size.…”
Section: Discussionmentioning
confidence: 99%
“…IRS-1 expression is often increased in human cancer (3), and overexpression or ectopic expression of IRS-1 causes cell transformation, including the ability to form colonies in soft agar and tumors in mice (4,5). When IRS-1 levels are decreased by experimental procedures (antisense or small interfering RNA), cancer cells lose their transformed phenotype (6)(7)(8). IRS-1 levels are low or even absent in differentiating cells (2,9,10), and ectopic expression of IRS-1 inhibits differentiation (4,10).…”
Section: Introductionmentioning
confidence: 99%
“…15,[23][24][25][26][27][28][29][30] Conversely, downregulation of IRS-1 (by antisense or siRNA) reverses the transformed phenotype. [30][31][32][33] One intriguing aspect of IRS-1 downregulation is that cells that do not express IRS-1 survive, although they have a tendency to differentiate (see above). A similar situation occurs with the IGF-IR.…”
Section: Discussionmentioning
confidence: 99%
“…This last property of IRS-1 is the focus of the present communication. When IRS-1 levels are decreased by experimental procedures, cancer cells lose their transformed phenotype (D'Ambrosio et al, 1995;del Rincon et al, 2004). Over-expression or ectopic expression of IRS-1 causes cell transformation, including the ability to form colonies in soft agar and tumors in mice (Cristofanelli et al, 2000;Valentinis et al, 2000;DeAngelis et al, 2006;Dearth et al, 2006).…”
Section: Introductionmentioning
confidence: 99%