Retinoic acid syndrome followed by scrotal ulcer during treatment of acute promyelocytic leukemia with all-trans retinoic acid

Gowda, Nishil; Atri, SudhirK; Dhanda, Anjali; Ambalavana, Karthik

doi:10.4103/jco.jco_11_20

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2023

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“…We feel that ATRA-related genital ulcers are grossly underreported due to the anatomical site and painless nature of these ulcers. [ 3 4 5 ]…”

Section: Discussionmentioning

confidence: 99%

Genital ulcers following all-trans-retinoic acid therapy

Saraswat,

Kumar,

Prem

et al. 2023

Indian Journal of Pharmacology

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All-trans-retinoic acid (ATRA) has transformed the treatment of acute promyelocytic leukemia. Most of the adverse effects associated with this drug are minor barring differentiation syndromes. Genital ulcers feature among the underreported adverse effects of ATRA which needs to be kept in mind to avoid life-threatening complications. We describe two cases who developed genital ulcers while treated with ATRA.

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“…We feel that ATRA-related genital ulcers are grossly underreported due to the anatomical site and painless nature of these ulcers. [ 3 4 5 ]…”

Section: Discussionmentioning

confidence: 99%