Retinoid therapy for psoriasis

Yamauchi, Paul S.; Rizk, Dalia; Lowe, Nicholas J.

doi:10.1016/s0733-8635(03)00126-8

Cited by 35 publications

(25 citation statements)

References 40 publications

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“…However, both immunosuppressed patients having MCPyV-positive carcinoma in situ received orally administered acitretin, a second-generation systemic retinoid. Acitretin has been shown to interfere with various aspects of cutaneous inflammation, without evidence for immune suppression [29,30]. However, 2 other patients were also treated with this drug but remained negative for MCPyV.…”

Section: Discussionmentioning

confidence: 99%

Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin

Mertz

Pfaltz²,

Junt

et al. 2010

Human Pathology

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Section: Discussionmentioning

confidence: 99%

Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin

Mertz

Pfaltz²,

Junt

et al. 2010

Human Pathology

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“…Retinoic acid was the first morphogen to be identified in vertebrates (Vergara et al, 2005), and numerous studies have elucidated the important role of retinoic acid in many physiological processes, including limb development (Thaller and Eichele, 1996), lens development and regeneration (Tsonis et al, 2000), lung development and regeneration (Maden, 2004), development of the central nervous system (Maden, 2002), reproduction (ClagettDame and DeLuca, 2002), hematopoiesis (Collins, 2002), as well as pathological conditions such as cancer (Soprano et al, 2004;Niles, 2004;Bertram and Vine, 2005), skin diseases (Yamauchi et al, 2004;Chivot, 2005), premature birth (Mactier and Weaver, 2005), rheumatoid arthritis (Beehler et al, 2004), and osteoporosis (Genaro and Martini, 2004).…”

Section: Physiological Functions Of Retinoic Acidmentioning

confidence: 99%

Overview of retinoid metabolism and function

2006

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Retinoids (vitamin A) are crucial for most forms of life. In chordates, they have important roles in the developing nervous system and notochord and many other embryonic structures, as well as in maintenance of epithelial surfaces, immune competence, and reproduction. The ability of all-trans retinoic acid to regulate expression of several hundred genes through binding to nuclear transcription factors is believed to mediate most of these functions. The role of all-trans retinoic may extend beyond the regulation of gene transcription because a large number of noncoding RNAs also are regulated by retinoic acid. Additionally, extra-nuclear mechanisms of action of retinoids are also being identified. In organisms ranging from prokaryotes to humans, retinal is covalently linked to G protein-coupled transmembrane receptors called opsins. These receptors function as light-driven ion pumps, mediators of phototaxis, or photosensory pigments. In vertebrates phototransduction is initiated by a photochemical reaction where opsin-bound 11-cis-retinal is isomerized to all-trans-retinal. The photosensitive receptor is restored via the retinoid visual cycle. Multiple genes encoding components of this cycle have been identified and linked to many human retinal diseases. Central aspects of vitamin A absorption, enzymatic oxidation of all-trans retinol to all-trans retinal and all-trans retinoic acid, and esterification of all-trans retinol have been clarified. Furthermore, specific binding proteins are involved in several of these enzymatic processes as well as in delivery of all-trans retinoic acid to nuclear receptors. Thus, substantial progress has been made in our understanding of retinoid metabolism and function. This insight has improved our view of retinoids as critical molecules in vision, normal embryonic development, and in control of cellular growth, differentiation, and death throughout life.

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“…38 The combination of methotrexate and acitretin has been used in patients with severe psoriasis, where all other treatments have failed. 39,40 This has been based on anecdotal evidence extrapolated from etretinate.…”

Section: Other Combinationsmentioning

confidence: 99%