Retinol‐binding protein 4 is positively associated with bone mineral density in patients with type 2 diabetes and osteopenia or osteoporosis

Huang, Nana; Zhou, Jin; Wang, Wei; Wang, Qiuling; Tang, Yuxiao; Sun, Yu; Wang, Daping; Chen, Shulin

doi:10.1111/cen.13560

Cited by 12 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those patients, who had traumatic fractures and fractures occurring at sites not characteristic of bone fragility (face, skull, tibia, fibula and femoral diaphysis), were excluded from the analysis [ 22 ]. In our present study, diabetic osteoporosis was diagnosed according to T score at any of sites on the LS, FN and TH and self-reported fragility fractures [ 19 , 23 ]. All participants were subsequently divided into three groups: normal group ( n = 73), osteopenia group ( n = 120), and osteoporosis group ( n = 121).…”

Section: Methodsmentioning

confidence: 99%

Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population

Chen

Yan

Wan

et al. 2021

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Altered circulating levels and genetic variation of B-type natriuretic peptide (BNP), has been associated with lower bone mineral density (BMD) values and incidence of osteoporosis in peritoneal dialysis patients, renal transplant recipients, and postmenopausal women. The potential relationship of circulating BNP with osteoporosis in patients with type 2 diabetes mellitus (T2DM), however, has not yet been studied. Methods Circulating BNP levels were measured in 314 patients with T2DM, and participants were divided into normal BMD group (n = 73), osteopenia group (n = 120), and osteoporosis group (n = 121). The association of circulating BNP with diabetic osteoporosis and other parameters was analyzed. Results Circulating BNP was significantly higher in diabetic osteoporosis subjects than normal and osteopenia groups (P < 0.01 or P < 0.05). Circulating BNP levels correlated significantly and positively with neutrophil to lymphocyte ratio, systolic blood pressure, urinary albumin-to-creatinine ratio, and prevalence of hypertension, peripheral arterial disease, diabetic retinopathy, peripheral neuropathy, and nephropathy, and negatively with triglyceride, fasting blood glucose, lymphocyte count, hemoglobin, estimated glomerular filtration rate, bilirubin, osteoporosis self-assessment tool for Asians, BMD at different skeletal sites and corresponding T scores (P < 0.01 or P < 0.05). After multivariate adjustment, circulating BNP remained independently significantly associated with the presence of osteoporosis (odds ratio, 2.710; 95% confidence interval, 1.690–4.344; P < 0.01). BMD at the femoral neck and total hip and corresponding T scores were progressively decreased, whereas the prevalence of osteoporosis was progressively increased with increasing BNP quartiles (P for trend< 0.01). Moreover, receiver-operating characteristic analysis revealed that the optimal cutoff point of circulating BNP to indicate diabetic osteoporosis was 16.35 pg/ml. Conclusions Circulating BNP level may be associated with the development of osteoporosis, and may be a potential biomarker for diabetic osteoporosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population

Chen

Yan

Wan

et al. 2021

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

“…Population study also showed consistent results: a study enrolled 355 patients grouped by different levels of BMD showed that the RBP, as well as alkaline phosphatize, was positively correlated with BMD at the lumbar spine, femoral neck, and hip [ 13 ]. Moreover, a study comparing the predictive efficiency of various bone parameters reported that RBP, after alkaline phosphatase and age, was the strongest predictor for BMD in treated postmenopausal osteoporosis [ 23 ].…”

Section: Discussionmentioning

confidence: 89%

“…RBP is synthesized by the liver and widely distributed in the blood, cerebrospinal fluid, and urine [ 11 ]. It is reported that RBP was positively associated with bone mineral density (BMD) and the retinol binding protein 4 (RBP4) may also affect the formation of chondrocytes [ 12 , 13 ]. At the same time, RBP is also used as a sensitive evaluation index of clinical nutritional status for the diagnosis of early malnutrition [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of retinol binding protein in geriatric hip fractures after surgeries: A propensity score matching and 1-year follow-up study

Liu

Yang

et al. 2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background We aimed to explore the predictive value of retinol binding protein (RBP) for outcomes of hip fractures. Methods Patients with hip fractures who underwent hip surgeries between December 2017 and February 2021 and met the inclusion criteria were analyzed. Propensity score matching was used to reduce the bias of co-factors and ROC curves based on matched populations were created to determine the optimal cutoff point of RBP. The outcomes between patients with low levels of RBP and high levels of RBP were compared. Results Four hundred eighty patients were enrolled in this study and 69 patients died within one year. After a 1:1 PSM, patients with more than 1-year survival had significantly higher RBP (p = 0.013) than those who died within one year, as well as patients divided by 6-months survival (p = 0.012). Logistics analysis showed that low RBP may be an independent risk factor for 3-month survival, 6-month survival, 1-year survival, and 3-month free walking ability. Conclusion RBP may be associated with the survival and 3-month walking abilities of patients with hip fractures.

show abstract

“…Vitamin A an important role the development of various organs, including bone growth [88], contributing to bone health [89,90], and abnormal levels of Vitamin A may have a negative impact on bone growth [91][92][93][94]. Moreover, RBP4 is expressed during limb growth and this gene is also involved in chondrogenesis, collagen X transcription and bone mineral density [95][96][97]. Thrombospondin (THBS1) is a glycoprotein that regulates the structure of the extracellular matrix [98] being involved in the protection of chondrocytes, since it exerts pro-chondrogenic and anti-inflammatory function [99].…”

Section: Discussionmentioning

confidence: 99%

RNA-seq reveals downregulated osteochondral genes potentially related to tibia bacterial chondronecrosis with osteomyelitis in broilers

et al. 2020

View full text Add to dashboard Cite

Background Bacterial chondronecrosis with osteomyelitis (BCO) develops in the growth plate (GP) of the proximal femur and tibia and is initiated by damage to the less mineralized chondrocytes followed by colonization of opportunistic bacteria. This condition affects approximately 1% of all birds housed, being considered one of the major causes of lameness in fast growing broilers. Although several studies have been previously performed aiming to understand its pathogenesis, the molecular mechanisms involved with BCO remains to be elucidated. Therefore, this study aimed to generate a profile of global differential gene expression involved with BCO in the tibia of commercial broilers, through RNA sequencing analysis to identity genes and molecular pathways involved with BCO in chickens. Results Our data showed 192 differentially expressed (DE) genes: 63 upregulated and 129 downregulated in the GP of the tibia proximal epiphysis of BCO-affected broilers. Using all DE genes, six Biological Processes (BP) were associated with bone development (connective tissue development, cartilage development, skeletal system development, organ morphogenesis, system development and skeletal system morphogenesis). The analyses of the upregulated genes did not indicate any significant BP (FDR < 0.05). However, with the downregulated genes, the same BP were identified when using all DE genes in the analysis, with a total of 26 coding genes explaining BCO in the tibia: ACAN, ALDH1A2, CDH7, CHAD, CHADL, COL11A1, COMP, CSGALNACT1, CYR61, FRZB, GAL3ST1, HAPLN1, IHH, KIF26B, LECT1, LPPR1, PDE6B, RBP4A, SERINC5, SFRP1, SOX8, SOX9, TENM2, THBS1, UCHL1 and WFIKKN2. In addition, seven transcription factors were also associated to BCO: NFATC2, MAFB, HIF1A-ARNT, EWSR1-FLI1, NFIC, TCF3 and NF-KAPPAB. Conclusions Our data show that osteochondral downregulated genes are potential molecular causes of BCO in broilers, and the bacterial process seems to be, in fact, a secondary condition. Sixteen genes responsible for bone and cartilage formation were downregulated in BCO-affected broilers being strong candidate genes to trigger this disorder.

show abstract

Retinol‐binding protein 4 is positively associated with bone mineral density in patients with type 2 diabetes and osteopenia or osteoporosis

Abstract: Serum RBP4 was positively associated with BMD at all sites after adjustments for other factors in osteopenia and osteoporosis groups compared with normal bone mineral density group of type 2 diabetic patients.

Cited by 12 publications

References 31 publications

Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population

Association of circulating B-type natriuretic peptide with osteoporosis in a Chinese type 2 diabetic population

The prognostic value of retinol binding protein in geriatric hip fractures after surgeries: A propensity score matching and 1-year follow-up study

RNA-seq reveals downregulated osteochondral genes potentially related to tibia bacterial chondronecrosis with osteomyelitis in broilers

Contact Info

Product

Resources

About