Retinopathy of prematurity

Prevalência de retinopatia da prematuridade em prematuros atendidos no período de 1992-1999 em Joinville (SC): avaliação de riscos associados - "screening"

“…A aceitação da classificação internacional da ROP (1984)(1985)(1986)(1987) ajudou imensamente a reconhecer cientificamente, em linguagem única, as mudanças vasculares que ocorrem nas retinas dos prematuros, assim como estabelecer parâmetros para o seu tratamento (7)(8)(9) . Vários fatores etiológicos foram associados ao desenvolvimento da ROP como peso ao nascimento e idade gestacional baixos, infecções, deficiência de vitamina E e A, exposição a luz entre outras (5,7,10) . Até 1992, Joinville não contava com nenhum acompanhamento oftalmológico de rotina e nenhuma maternidade.…”

The Effect of Anemia on Retinopathy of Prematurity in Extremely Low Birth Weight Infants

“…6 Numerous retrospective studies have examined potential risk factors contributing to development of ROP. These have included low gestational age at birth, 7 ± 12 low birth weight, 5,10,12 ± 14 male sex, 9 white race, 12,15 bronchopulmonary dysplasia, 5,10,13,16 sepsis, 8,13 acidosis, 7,11,16 oxygen therapy, 14,17 hyperoxia, 2,11,18 hypocarbia, 19 hypoxia, 1,11,19 and maternal use of beta blockers immediately before birth. 14 Recently, a case of neonatal HIV infection after blood transfusion at another institution led to a decrease in blood transfusions in premature infants at that hospital.…”

Hemopexin in the human retina: Protection of the retina against heme-mediated toxicity

“…Iron, in a chelated low molecular weight form, may be released from RPE cells into the retina as a consequence of the normal transport of iron into the eye for metabolic purposes (Hunt and Davis, 1992) and both iron and heme may enter retinal cells as a result of hemorrhage or cellular necrosis. The combination of oxygenation, light irradiation, and various forms of non-protein bound iron and heme, resulting in R02S formation, has been suggested to be a component of several diseases including retinopathy of prematurity (Katz and Robison, 1988;Ben Sira et al, 1988;Halliwell, 19921, and, perhaps also, diabetic retinopathy and sickle cell retinopathy.…”