Retinopatía de la prematuridad y oxigenoterapia: una relación cambiante

Sola, Augusto; Chow, Lily C.; Rogido, M.

doi:10.1157/13070182

Cited by 38 publications

(16 citation statements)

References 69 publications

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“…ROP is associated with low gestational age and birth weight; although advances in neonatal care have resulted in improved survival rates for premature infants, the incidence of ROP has increased (2,3). Numerous studies have been undertaken to examine the pathophysiological mechanisms of ROP (4,5); however, these currently remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Differentially expressed miRNAs in oxygen-induced retinopathy newborn mouse models

Wang

Yang

et al. 2016

Molecular Medicine Reports

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The present study aimed to identify microRNAs (miRNAs) involved in regulating retinal neovascularization and retinopathy of prematurity (ROP). A total of 80 healthy C57BL/6 neonatal mice were randomly divided into the oxygen-induced retinopathy (OIR) group (n=40), in which 7-day-old mice were maintained in 75% oxygen conditions for 5 days, or the control group (n=40). Following collection of retinal tissue, retinal angiography and hematoxylin and eosin (H&E) staining were performed. Total RNA was also extracted from retinal tissue, and miRNA microarrays and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were performed to identify differentially expressed miRNAs in the two groups. Retinal angiography and H&E staining revealed damage to retinas in the OIR group. Compared with the control group, 67 miRNAs were differentially expressed in the OIR group, of which 34 were upregulated and 33 were downregulated. Of these differentially expressed miRNAs, 32 exhibited a fold change ≥2, of which 21 were upregulated and 11 were downregulated. The results of RT-qPCR for miR-130a-3p and miR-5107-5p were in accordance with those of the miRNA microarray. The newly identified miRNAs may be important in the development of ROP, and may provide a basis for future research into the mechanisms of ROP.

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Section: Introductionmentioning

confidence: 99%

Differentially expressed miRNAs in oxygen-induced retinopathy newborn mouse models

Wang

Yang

et al. 2016

Molecular Medicine Reports

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“…Ocular manifestations from HBOT may also be described, particularly hyperbaric myopia, transitory in most cases. Other ophthalmological complications less frequent observed are cataracts, keratoconus or retinopathy of prematurity, in the case of pregnant women exposed to HBOT [207,208]. All these adverse effects may be ameliorated prominently by an adequate screening, through the use of certain devices and the adjustment of the treatment protocols [200,201] On the other hand, there are certain conditions in which HBOT might be absolutely contraindicated or relatively contraindicated.…”

Section: Adverse Effects and Contraindicationsmentioning

confidence: 99%

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

et al. 2021

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Hyperbaric oxygen therapy (HBOT) consists of using of pure oxygen at increased pressure (in general, 2–3 atmospheres) leading to augmented oxygen levels in the blood (Hyperoxemia) and tissue (Hyperoxia). The increased pressure and oxygen bioavailability might be related to a plethora of applications, particularly in hypoxic regions, also exerting antimicrobial, immunomodulatory and angiogenic properties, among others. In this review, we will discuss in detail the physiological relevance of oxygen and the therapeutical basis of HBOT, collecting current indications and underlying mechanisms. Furthermore, potential areas of research will also be examined, including inflammatory and systemic maladies, COVID-19 and cancer. Finally, the adverse effects and contraindications associated with this therapy and future directions of research will be considered. Overall, we encourage further research in this field to extend the possible uses of this procedure. The inclusion of HBOT in future clinical research could be an additional support in the clinical management of multiple pathologies.

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“…A proporção do sexo masculino e feminino dentre os que apresentaram o diagnóstico de ROP não apontou uma diferença significativa na probabilidade de ter ROP, enquanto que, no estudo de Sola et al 17 , o sexo masculino e a raça branca foram fatores de risco para retinopatia.…”

Section: ▄ Discussãounclassified

“…O estudo de Sola et al 17 relata a forte relação entre a oxigenoterapia e a ROP, e lembra a necessidade de pesquisas que falem dos níveis suficientes de oxigênio para cada recém-nascido, com o intuito de prevenir os casos mais graves.…”

Section: ▄ Discussãounclassified

Fatores associados e predição da retinopatia da prematuridade

et al. 2018

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Cad. Saúde Colet., 2018, Rio de Janeiro, 26 (1) ResumoIntrodução: A retinopatia da prematuridade (ROP) é uma doença vasoproliferativa, que afeta a retina das crianças que nascem prematuramente; assim, este estudo propôs identificar fatores associados e predizer a retinopatia na prematuridade. Método: Realizou-se um estudo transversal, com recém-nascidos prematuros, dividindo-os em dois grupos: com e sem retinopatia. As variáveis foram categorizadas por meio do teste da razão de verossimilhança e as variáveis que obtiveram p-valores menores que 0,2 foram analisadas por um modelo logístico múltiplo. A capacidade de predição do modelo foi realizada por meio da construção da curva ROC. Resultados: Dos 296 recém-nascidos, 32 (10,81%) apresentaram retinopatia. No modelo logístico, as variáveis que apresentaram fator de risco foram idade gestacional ≤ 30 semanas (p-valor=0,0214), peso ao nascer ≤ 1.250 gramas (p-valor=0,0013) e escore Apgar no primeiro minuto < 7 (p-valor=0,0352). A curva ROC com sensibilidade 0,771 e especificidade 0,774 evidenciou o modelo com precisão de 0,8448 e ponto de probabilidade de 0,79. Conclusões: Este modelo pode ser usado para predição de retinopatia em recém-nascidos prematuros com um fator de risco de 0,79, destacando que estes necessitam de maior atenção. Palavras-chave: retinopatia da prematuridade; fatores de risco; modelos logísticos. Abstract Introduction: Retinopathy of prematurity (ROP) is a vasoproliferative disease that affects the retina of prematurely born children. Therefore, this study proposed to identify associated factors and to predict retinopathy in prematurity. Method: A cross-sectional study including preterm newborns divided into two groups: with and without retinopathy. The variables were categorized using the likelihood ratio test, and the variables with p-values less than 0.2 were analyzed by a multiple logistic model. The model used the construction of a Receiver Operating Characteristic (ROC) curve as predicting tool. Results: Of the 296 newborns, 32 (10.81%) had retinopathy. The following variables represented a risk factor according to the logistic model: gestational age ≤ 30 weeks (p-value = 0.0214), birth weight ≤ 1250 grams (p-value = 0.0013) and Apgar score at 1 minute <7 (p-value = 0.0352). The ROC curve with sensitivity of 0.771 and specificity of 0.774 was a precise model, showing accuracy of 0.8448 and a probability point of 0.79. Conclusions: This model can be used to predict retinopathy in premature newborns with a risk factor of 0.79, emphasizing that the need for additional attention.

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Retinopatía de la prematuridad y oxigenoterapia: una relación cambiante

Cited by 38 publications

References 69 publications

Differentially expressed miRNAs in oxygen-induced retinopathy newborn mouse models

Differentially expressed miRNAs in oxygen-induced retinopathy newborn mouse models

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

Fatores associados e predição da retinopatia da prematuridade

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