RETIRED: Induction of Labour

Leduc, Dean; Biringer, Anne; Lee, Lily; Dy, Jessica; Corbett, Thomas H.; Duperron, Louise; Lange, Ian; Muise, Suzanne; Parish, Barbara; Regush, Lexy; Wilson, Kathi; Yeung, Grace; Crane, Joan; Gagnon, Robert; Sawchuck, Diane; Senikas, Vyta

doi:10.1016/s1701-2163(15)30842-2

Cited by 241 publications

(132 citation statements)

References 81 publications

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“…The Genesis study involving 2336 patients confirms a higher caesarean section rate in the primigravidas with induced labor compared to spontaneous labor (31% vs. 36%) [27]. It seems however that the caesarean section rate can be minimized when patient is qualified properly, especially in case of pregnancies past the estimated delivery date [6,10,28]. Pregnancies that require labor induction are often complicated with concomitant conditions like preeclampsia, hypertension or gestational diabetes, which as such increase the risk of caesarean section rate.…”

Section: %mentioning

confidence: 99%

“…Whether induction is successful depends on the cervix maturity, which is assessed usually with a modified Bishop score. When the cervix is not mature, pre-induction is required for the cervix to ripen [1,5,10]. Different methods can be used for pre-induction including mechanical (Foley catheter or Cook balloon) and pharmacological (prostaglandins) [1,2,5,8,10].…”

Section: Introductionmentioning

confidence: 99%

“…When the cervix is not mature, pre-induction is required for the cervix to ripen [1,5,10]. Different methods can be used for pre-induction including mechanical (Foley catheter or Cook balloon) and pharmacological (prostaglandins) [1,2,5,8,10]. The WHO and FDA recommend the use of prostaglandins in labor induction and pre-induction for numerous reasons.…”

Section: Introductionmentioning

confidence: 99%

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Obstetric outcomes of pre-induction of labor with a 200 μg misoprostol vaginal insert

et al. 2017

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Objectives: Labor induction is indicated in 20% to 40% of pregnancies. Over half of pregnancies qualified for the induction of labor require stimulation of the cervix to ripen. The drug used increasingly more often in pre-induction is the PGE-1 prostaglandin analog -misoprostol 200 μg. Material and methods:The study includes a total of 100 patients qualified for labor pre-induction with Misodel® (misoprostol 200 μg vaginal insert). The study group comprises two subgroups: primigravidas and multiparas. Assessments included: indications for labor pre-induction, time from Misodel application to delivery, caesarean section rate and indications, duration of first and second stage of labor, rate of vaginal deliveries, need for oxytocin or fenoterol administration side effects and newborn condition. Results:The most common indication for labor induction was gestational diabetes and pregnancy past term. The average time to vaginal delivery was 14 h 45 min, time to the onset of active phase of labor -11 h 45 min, time to membranes' rupture -15 h, time to vaginal delivery -14 h 18 min. The times of multiparas were significantly shorter. The rate of vaginal deliveries within 12 hours amounted to 42.42%, while within 24 hours it reached 83.33%. The overall caesarean section rate was 33%. The most common indication for caesarean section was the risk of intrauterine hypoxia. Tachysystole and hyperstimulation was observed in 4% of cases, while abnormalities in the cardiotocographic tracing in 43%. Conclusions:Misodel is an effective method for labor pre-induction, without affecting the caesarean section rate and has no adverse effect on the newborn condition.

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Section: %mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Obstetric outcomes of pre-induction of labor with a 200 μg misoprostol vaginal insert

et al. 2017

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“…About 7% of all pregnancies are post-term pregnancy [39]. Dean Leduce and Jarson Gardosi recorded postdates as highest indication for induction of labor [16,40]. Similarly, frequent indication for induction was postdates observed by Guerra et al [10,26,41] Along with postdates, the hypertensive diseases of pregnancy are many times become the main indications for induction of labor [21].…”

Section: Resultsmentioning

confidence: 99%

“…The reasons for considering induction are many and vary from obstetrician to obstetrician and from country to country [8]. The most common indication that requires induction of labor is postdated pregnancy [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Another frequently cited indication is term premature rupture of membrane [12,13,23,24].…”

Section: Introductionmentioning

confidence: 99%

Induction of Labor by Prostaglandin: A Review for Indications and Risk for Cesarean Section

Tripathy

Baby

2017

Asian J Pharm Clin Res

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Objective: Labor induction by medication is now preferred by many obstetricians. The impact of induction remains ambiguous, although many studies and systematic reviews have been conducted. Few studies have reported for its better outcomes while other studies with poor outcomes. The objective of the study is to identify the common indications of induction and the risk of cesarean section after induction. Methods:Various standardized databases, such as Pub Med, Scopus, and Google Scholar, were used to collect the scientific studies, where prostaglandin was used as drug of choice for induction of labor. The key words used were induction of labor, indications of induction, induction by misoprostol, induction and risk of cesarean section, etc. The survey spans over 22 years of study articles published from the year 1995-2017.Result: A total of 112 studies have been included to analyze the indications and risk of cesarean section. The most common indication found in most of the studies was post-term pregnancy. The risk of cesarean section varied from 3% to 48.7%. The common reasons for which the cesarean section was planned were, failed induction, nonprogress of labor, fetal distress, and undiagnosed CPD. Conclusion:Most of the studies recommend induction of labor as a safer option with lower risk of c-section.

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Comparison of Maternal Labor-Related Complications and Neonatal Outcomes Following Elective Induction of Labor at 39 Weeks of Gestation vs Expectant Management

et al. 2023

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ImportanceElective induction of labor at 39 weeks of gestation is common. Thus, there is a need to assess maternal labor-related complications and neonatal outcomes associated with elective induction of labor.ObjectiveTo examine maternal labor-related complications and neonatal outcomes following elective induction of labor at 39 weeks compared with expectant management.Data SourcesA systematic review of the literature was conducted using the MEDLINE (Ovid), Embase (Ovid), Cochrane Central Library, World Health Organization, and ClinicalTrials.gov databases and registries to search for articles published between database inception and December 8, 2022.Study SelectionThis systematic review and meta-analysis included randomized clinical trials, cohort studies, and cross-sectional studies reporting perinatal outcomes following induction of labor at 39 weeks vs expectant management.Data Extraction and SynthesisTwo reviewers independently assessed study eligibility, extracted data, and assessed studies for bias. Pooled odds ratios (ORs) and 95% CIs were calculated using a random-effects model. This study is reported per the Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 guideline, and the protocol was prospectively registered with PROSPERO.Main Outcomes and MeasuresMaternal outcomes of interest included emergency cesarean section, perineal injury, postpartum hemorrhage, and operative vaginal birth. Neonatal outcomes of interest included admission to the neonatal intensive care unit, low 5-minute Apgar score (&lt;7) after birth, macrosomia, and shoulder dystocia.ResultsOf the 5827 records identified in the search, 14 studies were eligible for inclusion in this review. These studies reported outcomes for 1 625 899 women birthing a singleton pregnancy. Induction of labor at 39 weeks of gestation was associated with a 37% reduced likelihood of third- or fourth-degree perineal injury (OR, 0.63 [95% CI, 0.49-0.81]), in addition to reductions in operative vaginal birth (OR, 0.87 [95% CI, 0.79-0.97]), macrosomia (OR, 0.66 [95% CI, 0.48-0.91]), and low 5-minute Apgar score (OR, 0.62 [95% CI, 0.40-0.96]). Results were similar when confined to multiparous women only, with the addition of a substantial reduction in the likelihood of emergency cesarean section (OR, 0.61 [95% CI, 0.38-0.98]) and no difference in operative vaginal birth (OR, 1.01 [95% CI, 0.84-1.21]). However, among nulliparous women only, induction of labor was associated with an increased likelihood of shoulder dystocia (OR, 1.22 [95% CI, 1.02-1.46]) compared with expectant management.Conclusions and RelevanceIn this study, induction of labor at 39 weeks was associated with improved maternal labor-related and neonatal outcomes. However, among nulliparous women, induction of labor was associated with shoulder dystocia. These results suggest that elective induction of labor at 39 weeks may be safe and beneficial for some women; however, potential risks should be discussed with nulliparous women.

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RETIRED: Induction of Labour

Cited by 241 publications

References 81 publications

Obstetric outcomes of pre-induction of labor with a 200 μg misoprostol vaginal insert

Obstetric outcomes of pre-induction of labor with a 200 μg misoprostol vaginal insert

Induction of Labor by Prostaglandin: A Review for Indications and Risk for Cesarean Section

Comparison of Maternal Labor-Related Complications and Neonatal Outcomes Following Elective Induction of Labor at 39 Weeks of Gestation vs Expectant Management

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