RETRACTED: Antioxidant properties of benzylchroman derivatives from <i>Caesalpinia sappan</i> L. against oxidative stress evaluated <i>in vitro</i>

Lee, Min Ja; Lee, Hye-Sook; Kim, Hyuck; Yi, Hyo-Seung; Park, Sun-Dong; Moon, Hyung‐In; Park, Won‐Hwan

doi:10.3109/14756360903373376

Cited by 10 publications

(8 citation statements)

References 22 publications

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“…The total phenolic content of a plant is considered an indicator of its antioxidant capacity because the redox properties of phenolic compounds allow them to act as reducing agents, hydrogen donors, and radical scavengers [22]. Previously, Lee et al [26] reported that ethanolic C. sappan extract had a total phenolic content of 723.67 μg GAE/mg. The values of total phenolic content in this study were slightly Abu-Jafar and Huleihel [27] reported that ethanolic Eucalyptus camaldulensis leave extracts had strong antiviral activity against different members of the herpes virus family (HSV-1, HSV-2, and VZV).…”

Section: Discussionmentioning

confidence: 99%

In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

et al. 2020

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Background: Porcine reproductive and respiratory syndrome (PRRS) caused by PRRS virus (PRRSV) results in economic losses in the swine industry globally. Several studies have investigated the use of plant extracts in the prevention and control of PRRS outbreaks. Thai medicinal plants may be useful for treating PRRSV infection in pigs. Therefore, we investigated the in vitro anti-PRRSV and antioxidant properties of seven Thai medicinal plants: Caesalpinia sappan Linn., Garcinia mangostana Linn., Houttuynia cordata, Perilla frutescens, Clinacanthus nutans, Phyllanthus emblica, and Tiliacora triandra. Results: Using antiviral screening, we observed that T. triandra extract strongly inhibited PRRSV infectivity in MARC-145 cells [virus titer 3.5 median tissue culture infective dose (TCID 50)/ml (log10)] at 24 h post-infection, whereas C. sappan extract strongly inhibited PRRSV replication [virus titer 2.5 TCID 50 /ml (log10)] at 72 h post-infection. C. sappan extract had the highest total phenolic content [220.52 mM gallic acid equivalent/g] and lowest half-maximal inhibitory concentration [1.17 mg/ml in 2,2-diphenyl-1-picrylhydrazyl and 2.58 mg/ml in 2,2-azino-bis (3ethylbenzothiazo-line-6-sulfonic acid) diammonium salt]. Conclusion: T. triandra extract could inhibit PRRSV infectivity, whereas C. sappan extract was the most effective in inhibiting PRRSV replication in MARC-145 cells. This study elucidates the antiviral activities of Thai medicinal plant extracts in vivo. The results promise that Thai medicinal plant extracts, particularly T. triandra and C. sappan extracts, can be developed into pharmaceutical drugs for the prevention of PRRS in pigs.

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Section: Discussionmentioning

confidence: 99%

In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

et al. 2020

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“…These compounds are in the form of brazilin, chalcone and sappanin, sappan calchone which can be used as primary and secondary antioxidants [7][8][9][10]. The content of brazilin compounds in secang wood can inhibit the protein inhibitor of apoptosis survivin and is involved in the activation of caspase 3 and caspase 9, so that it can treat cancer [11][12][13]. Secang contains phenolic compounds such as flavonoids, which have antioxidants as free radical scavengers [14].…”

Section: Introductionmentioning

confidence: 99%

The effect of Caesalpinia sappan extract on body weight and carcass weight of bucks (Cuniculus forma domestica) exposed to heat stress

Agustono

Safitri

Saputro

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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The aim of this research was to determine the effect of Caesalpinia sappan L. extract on body weight and carcass weight of bucks exposed by heat stress. This research used a completely randomized design with 4 treatments and 5 replications. The experimental animal were 5 month old bucks of rex type. The bucks were divided into 4 groups and given different treatments for 28 days, namely K + (complete feed + heat stress), K- (complete feed), P1 (complete feed + Caesalpinia sappan L. 100mg/kg feed + heat stress), and P2 (complete feed + Caesalpinia sappan L. 300 mg/kg feed + heat stress). The observed variables were the body weight and the carcass weight of the bucks. Parametric data was analyzed using ANOVA. The average body weight was K+ (2220.00), K- (2239.80), P1 (2241.60), P2 (2242.00). The average carcass weight was K+ (1132.40), K- (1232.00), P1 (1233.00), P2 (1233.20). The results of study showed that there was a significant difference (P<0.05) between the treatment and control group. Based on the research conducted, it can be concluded that the administration of Caesalpinia sappan L. extract can maintain the body weight and carcass weight of buck exposed to heat stress.

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“…Natural chalcones bearing 3,4-dihydroxyl groups, such as butein, sappanchalcone and okanin, are particularly effective antioxidants 67. , 68. , 69.…”

Section: Discussionmentioning

confidence: 99%

“…Phenolic compounds possess high antioxidant activity and are potent regulators of cellular redox status, which have been frequently considered as potent antioxidants. Natural chalcones bearing 3,4-dihydroxyl groups, such as butein, sappanchalcone and okanin, are particularly effective antioxidants67., 68., 69.. Chiruta et al 70 reported chalcone derivatives containing catechol group contributed to neuroprotective activity and maintenance of GSH.…”

Section: Discussionmentioning

confidence: 99%

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

Wang

Huang

Cheng

et al. 2019

Acta Pharmaceutica Sinica B

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Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H 2 O 2 -induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 could emerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment.

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RETRACTED: Antioxidant properties of benzylchroman derivatives from Caesalpinia sappan L. against oxidative stress evaluated in vitro

Cited by 10 publications

References 22 publications

In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

In vitro screening antiviral activity of Thai medicinal plants against porcine reproductive and respiratory syndrome virus

The effect of Caesalpinia sappan extract on body weight and carcass weight of bucks (Cuniculus forma domestica) exposed to heat stress

Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents

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