2014
DOI: 10.1007/s10719-014-9550-x
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RETRACTED ARTICLE: 9-O-acetylated sialic acids differentiating normal haematopoietic precursors from leukemic stem cells with high aldehyde dehydrogenase activity in children with acute lymphoblastic leukaemia

Abstract: Childhood acute lymphoblastic leukaemia (ALL) originates from mutations in haematopoietic progenitor cells (HPCs). For high-risk patients, treated with intensified post-remission chemotherapy, haematopoietic stem cell (HSC) transplantation is considered. Autologous HSC transplantation needs improvisation till date. Previous studies established enhanced disease-associated expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs) on lymphoblasts of these patients at diagnosis, followed by its decrease with… Show more

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Cited by 5 publications
(2 citation statements)
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“…GD2 O-acetylation is elevated in neuroblastoma and glioblastoma, which is a potential biomarker of therapeutic target ( 21 ). In childhood acute lymphoblastic leukemia, the expression of 9-O-acetylated sialoglycoprotein was enhanced, decreased with the remission of clinical symptoms, and increased again when the disease relapsed ( 22 ). These studies indicate that O-acetylation might be a potential biomarker and target for drug-targeted therapy ( 22 ).…”
Section: The Components and Process Of Acetylation System In Cancersmentioning
confidence: 99%
“…GD2 O-acetylation is elevated in neuroblastoma and glioblastoma, which is a potential biomarker of therapeutic target ( 21 ). In childhood acute lymphoblastic leukemia, the expression of 9-O-acetylated sialoglycoprotein was enhanced, decreased with the remission of clinical symptoms, and increased again when the disease relapsed ( 22 ). These studies indicate that O-acetylation might be a potential biomarker and target for drug-targeted therapy ( 22 ).…”
Section: The Components and Process Of Acetylation System In Cancersmentioning
confidence: 99%
“…In ALL, and especially in pediatric ALL, ALDH positivity is a marker of immaturity and stemness [36]. From the bone marrow of ALL patients, two cell populations could be separated, normal haematopoietic progenitor cells (ALDH(+)SSC(lo)CD45(hi)Neu5,9Ac2 -GPs(lo)CD34(+)CD38(-)CD90(+)CD117(+)CD133(+)) that differentiated into morphologically discrete, lineagespecific colonies, being essential for autologous HSC transplantation, while leukemic stem cells had the markers (ALDH(+)SSC(lo)CD45(lo)Neu5,9Ac2 -GPs(hi)CD34(+)CD38(+)CD90(-)CD117(-)CD133(-)) [37]. In B-ALL, ALDH+ cells formed 5-7 fold more colonies than ALDHneg cells in methylcellulose [38].…”
Section: Aldh Activity In Acute Leukemiamentioning
confidence: 99%