RETRACTED ARTICLE: Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR-181 level

Gong, Anjing; Ge, Na; Yao, Weicheng; Lu, Luxiang; Liang, Hui

doi:10.1007/s00280-014-2534-5

Cited by 21 publications

(18 citation statements)

References 11 publications

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“…Since miR-181b-abundant glioma cells is more sensitive to temozolomide (TMZ) [21], aplysin enhances TMZ action through increasing the expression of miR-181 in TMZ-resistant glioma cells, which results in MEK1 (mitogen-activated protein kinase kinase 1) downregulation [22]. …”

Section: Natural Compounds Affecting Mirnasmentioning

confidence: 99%

“…(1) Bioactivities of some miRNAs are similar with the pharmacological effects of a given natural compounds on cancer cells [5, 7, 8, 16,19, 21, 22, 24–27, 29, 30, 31], this similarity encourages researchers to wonder whether natural compound exhibits its effect by affecting these miRNAs. For example, miR-181 is related to TMZ-resistance of glioma, and interestingly, aplysin can also enhance the sensitivity of glioma cells to TMZ.…”

Section: Identification Of Natural Compound-related Mirnasmentioning

confidence: 99%

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Targeting microRNAs: a new action mechanism of natural compounds

Lin

Liu

et al. 2016

Oncotarget

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Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer. In this review, several natural compounds and their studies about miRNA-related action mechanism were summarized. These studies provide a new insight into action mechanism by which natural compound exerts its bioactivity and a novel treatment strategy, demonstrating natural compound a promising remedy for clinical treatments.

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Section: Natural Compounds Affecting Mirnasmentioning

confidence: 99%

Section: Identification Of Natural Compound-related Mirnasmentioning

confidence: 99%

Targeting microRNAs: a new action mechanism of natural compounds

Lin

Liu

et al. 2016

Oncotarget

View full text Add to dashboard Cite

show abstract

“…In addition, Gong et al . [ 137 ] demonstrated that aplysin ( 109 ) can enhance the effect of temozolomide (a chemotherapy drug) on glioma cells by increasing miR-181 expression. According to this, a recent study showed that aplysin ( 109 ) can actually induce apoptosis in glioma cells by interference with the HSP90/AKT pathway [ 138 ].…”

Section: Terpenoidsmentioning

confidence: 99%

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

2016

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The marine environment is an important source of structurally-diverse and biologically-active secondary metabolites. During the last two decades, thousands of compounds were discovered in marine organisms, several of them having inspired the development of new classes of therapeutic agents. Marine mollusks constitute a successful phyla in the discovery of new marine natural products (MNPs). Over a 50-year period from 1963, 116 genera of mollusks contributed innumerous compounds, Aplysia being the most studied genus by MNP chemists. This genus includes 36 valid species and should be distinguished from all mollusks as it yielded numerous new natural products. Aplysia sea hares are herbivorous mollusks, which have been proven to be a rich source of secondary metabolites, mostly of dietary origin. The majority of secondary metabolites isolated from sea hares of the genus Aplysia are halogenated terpenes; however, these animals are also a source of compounds from other chemical classes, such as macrolides, sterols and alkaloids, often exhibiting cytotoxic, antibacterial, antifungal, antiviral and/or antifeedant activities. This review focuses on the diverse structural classes of secondary metabolites found in Aplysia spp., including several compounds with pronounced biological properties.

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“…Present study demonstrated that aplysin was believed to enhance the effect of temozolomide on glioma cells by increasing miR181 expression. [ 44 ] At the molecular level, expression of cyclin B1 (a positive cell cycle regulator) could be negatively regulated by miR181, which inhibited glioma cell proliferation. [ 45 ] Furthermore, miR-181c could enhance the effect of miR-21 as an anticancer target against glioma.…”

Section: Icro Rna S and G mentioning

confidence: 99%

Role of MicroRNAs in Malignant Glioma

Wang

2015

Chinese Medical Journal

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Objective:This overview seeked to bring together the microRNA (miRNA) researches on biogenesis and bio-function in these areas of clinical diagnosis and therapy for malignant glioma.Data Sources:Using the keyword terms “glioma” and “miRNA,” we performed the literature search in PubMed, Ovid, and web.metstr.com databases from their inception to October 2014.Study Selection:In screening out the quality of the articles, factors such as clinical setting of the study, the size of clinical samples were taken into consideration. Animal studied for verification and reviews article were also included in our data collection.Results:Despite many advance in miRNA for malignant glioma, further studies were still required to focus on the following aspects: (i) Improving the understanding about biogenesis of miRNA and up-down regulation; (ii) utilizing high-throughput miRNA expression analysis to screen out the core miRNA for glioma; (iii) Focusing related miRNAs on the signal transduction pathways that regulate the proliferation and growth of glioma.Conclusions:We discussed the most promising miRNA, correlative signaling pathway and their relation with gliomas in the way of prompting miRNA target into being a clinical therapeutic strategy.

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RETRACTED ARTICLE: Aplysin enhances temozolomide sensitivity in glioma cells by increasing miR-181 level

Abstract: We found that aplysin can enhance the effect of TMZ on glioma cells by increasing miR-181 expression.

Cited by 21 publications

References 11 publications

Targeting microRNAs: a new action mechanism of natural compounds

Targeting microRNAs: a new action mechanism of natural compounds

Chemical Diversity and Biological Properties of Secondary Metabolites from Sea Hares of Aplysia Genus

Role of MicroRNAs in Malignant Glioma

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