RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

Peng, Qian; Linbo, Liu; Zhai, Xiaomei; Hui, Pei

doi:10.1038/s41419-020-2444-x

Cited by 27 publications

(25 citation statements)

References 28 publications

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“…Until now, benefiting from advances in RNA deep sequencing technology and bioinformatics, a large number of circRNAs has been detected in various cell lines and species [ 21 ]. Recent evidence suggests that circRNAs may play a crucial role in the occurrence and development of a variety of diseases, such as atherosclerosis, neurological disorders, prion diseases and cancers, by working as miRNA sponges, RNA-binding proteins or transcriptional regulators [ 22 , 23 ]. Some circRNAs that are deregulated in CRC tissues or cell lines, such as hsa_circ_0000069, hsa_circ_0014717, circular BANP and ciRS-7, have been implicated in proliferation, metastasis and poor prognosis of CRC, indicating their crucial roles in this malignancy [ 24 – 27 ].…”

Section: Introductionmentioning

confidence: 99%

Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Liang

Shi

et al. 2020

Cancer Cell Int

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Background Colorectal cancer (CRC) is one of the most common cancers worldwide. Circular RNAs (circRNAs), a novel class of non-coding RNAs, have been confirmed to be key regulators of many diseases. With many scholars devoted to studying the biological function and mechanism of circRNAs, their mysterious veil is gradually being revealed. In our research, we explored a new circRNA, hsa_circ_0026416, which was identified as upregulated in CRC with the largest fold change (logFC = 3.70) of the evaluated circRNAs via analysing expression profiling data by high throughput sequencing of members of the GEO dataset (GSE77661) to explore the molecular mechanisms of CRC. Methods qRT-PCR and western blot analysis were utilized to assess the expression of hsa_circ_0026416, miR-346 and Nuclear Factor I/B (NFIB). CCK-8 and transwell assays were utilized to examine cell proliferation, migration and invasion in vitro, respectively. A luciferase reporter assay was used to verify the combination of hsa_circ_0026416, miR-346 and NFIB. A nude mouse xenograft model was also utilized to determine the role of hsa_circ_0026416 in CRC cell growth in vivo. Results Hsa_circ_0026416 was markedly upregulated in CRC patient tissues and plasma and was a poor prognosis in CRC patients. In addition, the area under the curve (AUC) of hsa_circ_0026416 (0.767) was greater than the AUC of CEA (0.670), CA19-9 (0.592) and CA72-4 (0.575). Functionally, hsa_circ_0026416 promotes cell proliferation, migration and invasion both in vitro and in vivo. Mechanistically, hsa_circ_0026416 may function as a ceRNA via competitively absorbing miR-346 to upregulate the expression of NFIB. Conclusions In summary, our findings demonstrate that hsa_circ_0026416 is an oncogene in CRC. Hsa_circ_0026416 promotes the progression of CRC via the miR-346/NFIB axis and may represent a potential biomarker for diagnosis and therapy in CRC.

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Section: Introductionmentioning

confidence: 99%

Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Liang

Shi

et al. 2020

Cancer Cell Int

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“…Red and blue color indicated the oncogenic and suppressive functions of circRNAs in different biological processes involved in melanoma progression, respectively. Up and down arrows indicated the activation and inhibition of physiological processes in melanoma pathogenesis, respectively (Bian et al, 2018 ; Ju et al, 2018 ; Luan et al, 2018 ; Wang Q. et al, 2018 ; Lin et al, 2019 ; Shang et al, 2019 ; Zou et al, 2019 ; Chen J. et al, 2020 ; Chen Z. et al, 2020 ; Hanniford et al, 2020 ; Jin et al, 2020 ; Lu and Li, 2020 ; Lu et al, 2020 ; Qian et al, 2020 ; Tian et al, 2020 ; Wei et al, 2020 ; Liu et al, 2021 ; Yin et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“… Examples of regulatory interactions and biological effects of dysregulated circular RNAs (circRNAs) in melanoma (Luan et al, 2018 ; Chen J. et al, 2020 ; Chen Z. et al, 2020 ; Hanniford et al, 2020 ; Jin et al, 2020 ; Qian et al, 2020 ). …”

Section: Resultsmentioning

confidence: 99%

“…Its depletion suppresses invasion, migration, and proliferation of melanoma cells in vitro and tumor growth in vivo . One study showed that mir-144 regulated MAPK signaling pathway factors, such as DUSP5 and TGFBR1 (Qian et al, 2020 ). Other circRNAs which also acted as oncogene and miRNA sponge in melanoma included circ_0025039 (Bian et al, 2018 ), circ_0016418 (Zou et al, 2019 ; Lu et al, 2020 ), circ_0020710 (circ-CD151) (Wei et al, 2020 ), circ_0079593 (Lu and Li, 2020 ), circ_0001591 (Yin et al, 2021 ), and circ_0119872 (Liu et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

“…Patients with higher expression of circ_0025039 in melanomas had a shorter survival time than those with lower expression (Bian et al, 2018 ). circ_0002770 was remarkably increased in metastatic melanoma tissue and decreased in primary tumor tissue, indicating a smaller survival time and poorer prognosis (Qian et al, 2020 ). circ_0001591 level in blood serum negatively correlated with overall survival and disease-free survival of melanoma patients (Yin et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

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Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review

Tang

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are newly discovered RNAs with covalently looped structures. Due to their resistance to RNAase degradation and tissue-specific expression, circRNAs are expected to be potential biomarkers in early diagnosis and target treatment of many diseases. However, the role of circRNAs in melanoma still needs to be systematically reviewed for better understanding and further research. Based on published articles in PubMed, Embase, Cochrane Library, and Web of Science database, we systematically reviewed the implications and recent advances of circRNAs in melanoma, focusing on function, mechanism, and correlation with melanoma progression. According to inclusion and exclusion criteria, a total of 19 articles were finally included in this systematic review. Of the 19 studies, 17 used human samples, including melanoma tissues (n = 16) and blood serum of patients with melanoma (n = 1). The sample size of the study group ranged from 20 to 105 based on the reported data. Several studies explored the association between circRNAs and clinicopathological characteristics. circRNA dysregulation was commonly observed in melanoma patients. circRNAs function in melanoma by miRNA sponging and interaction with RNA binding proteins (RBP), ultimately controlling several important signaling pathways and cancer-related cellular processes, including proliferation, migration, invasion, metastasis, apoptosis, and glucose metabolism. circRNA expression could be associated with prognostic factors and drug responses, consolidating the potential clinical value in melanoma. Herein, we clarified the functional, prognostic, and predictive roles of circRNAs in melanoma in this systematic review, providing future directions for studies on melanoma-associated circRNAs.

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circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

et al. 2022

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Background Melanoma is an aggressive disease that is rising in incidence. Advanced melanoma is still a life‐threatening disease. CircRNAs are documented to be involved in melanoma progression. But circITCH role in melanoma remains unclear. Methods and Results To explore the functions of circITCH in melanoma, levels of circITCH in melanoma tissues and paracarcinoma normal tissues were detected. To study the roles of circITCH in melanoma in terms of cell proliferation and migration, in vitro and in vivo experiments were performed. Mechanism study was designed to investigate the potential regulatory effect of circITCH in melanoma. Results revealed that circITCH expression was repressed in melanoma versus adjacent normal tissues. Function study showed that circITCH suppressed melanoma cell proliferation and metastasis. The mechanism study showed that circITCH‐sponged miR‐660 to upregulate TFCP2 and suppress melanoma progression. Conclusions The circITCH/miR‐660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma.

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RETRACTED ARTICLE: Circ_0002770, acting as a competitive endogenous RNA, promotes proliferation and invasion by targeting miR-331-3p in melanoma

Cited by 27 publications

References 28 publications

Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis

Circular RNA as a Potential Biomarker for Melanoma: A Systematic Review

circITCH suppresses cell proliferation and metastasis through miR‐660/TFCP2 pathway in melanoma

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