Retracted Article: Circular RNA hsa_circ_0000467 modulates SGK1 to facilitate cell migration, metastasis, and EMT while repressing apoptosis in colorectal cancer by sponging miR-383-5p

Liu, Chong; Sun, Lingling; Sun, Jiaying

doi:10.1039/c9ra07900a

Cited by 1 publication

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, this miRNA has also reduced expressions of EMT markers including Snail-1, E-cadherin and VEGF as well as some other oncogenic proteins namely SMAD3 and AKT (Mansoori et al, 2020). In this type of cancer, miR-145-5p, miR-383-5p, miR-3622a-3p, miR-205 and miR-200b inhibit EMT process through targeting CDCA3, SGK1, SALL4, MDM4 and HIF-1α, respectively (Shang et al, 2017;Chong et al, 2019;Chang et al, 2020;Chen et al, 2020;Fan and Wang, 2020).…”

Section: Emt In Cancermentioning

confidence: 95%

The Impact of Non-coding RNAs in the Epithelial to Mesenchymal Transition

Hussen

Shoorei

Mohaqiq

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

Epithelial to mesenchymal transition (EMT) is a course of action that enables a polarized epithelial cell to undertake numerous biochemical alterations that allow it to adopt features of mesenchymal cells such as high migratory ability, invasive properties, resistance to apoptosis, and importantly higher-order formation of extracellular matrix elements. EMT has important roles in implantation and gastrulation of the embryo, inflammatory reactions and fibrosis, and transformation of cancer cells, their invasiveness and metastatic ability. Regarding the importance of EMT in the invasive progression of cancer, this process has been well studies in in this context. Non-coding RNAs (ncRNAs) have been shown to exert critical function in the regulation of cellular processes that are involved in the EMT. These processes include regulation of some transcription factors namely SNAI1 and SNAI2, ZEB1 and ZEB2, Twist, and E12/E47, modulation of chromatin configuration, alternative splicing, and protein stability and subcellular location of proteins. In the present paper, we describe the influence of ncRNAs including microRNAs and long non-coding RNAs in the EMT process and their application as biomarkers for this process and cancer progression and their potential as therapeutic targets.

show abstract