RETRACTED ARTICLE: Hepatic ameliorative role of vitamin B17
            against Ehrlich ascites carcinoma–induced liver toxicity

Tousson, Ehab; Hafez, Ezar; Gazia, Maha Mohamed Abo; Salem, Siham Bayomi; Mutar, Thulfiqar Fawwaz

doi:10.1007/s11356-019-06528-6

Cited by 48 publications

(46 citation statements)

References 51 publications

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“…(2020) and Tousson et al. (2020) revealed that pre‐ and simultaneous treatment of vitamin B17 (100 mg/kg b.w/day, intramuscularly) inhibited DNA damages in kidney and liver in the Ehrlich ascites carcinoma. It was suggested that Vitamin B17 had an ameliorative activity against Ehrlich ascites carcinoma‐induced kidney and liver injury and toxicity in mice.…”

Section: Discussionmentioning

confidence: 98%

“…It has been reported that amygdalin, either administered intramuscularly (P1: 0.6 mg/kg; P2: 3 mg/kg) or the animals were fed with a mixture of commercial diet and apricot kernels (P3: 60 mg/kg; P4: 300 mg/kg), had no significant effect on the formation of aneuploidy in rabbit blood cells (Curlej, Halenar, Kolesarova, Curlejova, & Chrenek, 2016). Besides, Mutar, Tousson, Hafez, Abo Gazia, and Salem (2020) and Tousson, Hafez, Gazia, Salem, and Mutar (2020) reported that vitamin B17 (100 mg/kg b.w/day, intramuscularly, 14 days) did not significantly induce DNA damage in kidney and liver in mice in the comet assay. In another study, amygdalin (100 and 200 μM) reduced DNA damage produced by pollution in blood samples taken from C. julis collected from the port of Augusta (Syracuse, Italy), where the pollution rate is quite high.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, Mutar, Tousson, Hafez, Abo Gazia, and Salem (2020) and Tousson, Hafez, Gazia, Salem, and Mutar (2020) reported that vitamin B17 (100 mg/kg b.w/day, intramuscularly, 14 days) did not significantly induce DNA damage in kidney and liver in mice in the comet assay. In another study, amygdalin (100 and 200 μM) reduced DNA damage produced by pollution in blood samples taken from C. julis collected from the port of Augusta (Syracuse, Italy), where the pollution rate is quite high.…”

Section: Discussionmentioning

confidence: 99%

“…Researchers explained that amygdalin triggered DNA repair capacity by stimulating special mechanisms (Di Mauro, Ferrito, Scifo, Renis, & Tomasello, 2017). Some researchers investigated the effects of vitamin B17 (amygdalin) in tumors developed by the administration of the Ehrlich tumor cells in mice using comet assay (El-Masry, Al-Shaalan, Tousson, Buabeid, & Al-Ghadeer., 2020;Mutar et al, 2020;Tousson et al, 2020). It was demonstrated that it significantly reduced (175 mg/Kg b.w/day, orally) the levels of tumor tissue in mice.…”

Section: Discussionmentioning

confidence: 99%

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Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay

2020

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Since ancient times, plants have always been a resource of medicines, primarily due to secondary metabolites, which have many pharmacological activities. Many of the drugs used today are based on natural bioactive products or their derivatives (Atanasov et al., 2015). Recently, natural bioactive products, in alternative forms, for instance, extracts, fractions, or phytochemicals, play an essential role in the prevention and treatment of major cancer types (lung, breast, colorectal, etc.) (Atanasov et al., 2015; Kim & Kim, 2018). These compounds exhibit their protective effects in cancer chemoprevention via some pharmacologic activities including antioxidant properties as well as modulating several genes involved in cellular antioxidant defenses, inflammation, metabolism, survival, and proliferation (Battino et al., 2019). Amygdalin (C 20 H 27 NO 11) is a cyanogenic diglycoside that is a secondary plant compound containing nitrile, which after its enzymatic degradation, releases cyanide as the final product

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay

2020

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“…[8][9][10] Recently, there is an obvious increase in the usage of complementary and alternative medication. [11][12][13][14][15] Curcumin is a significant yellow shaded polyphenolic compound got from the underlying foundations of turmeric (Curcuma longa), exhibit high antioxidant properties, and is utilized for the treatment of many diseases. 16 A few difficulties that bound to the clinical utilization of curcumin as its poor watery solvency, substance insecurity, fast digestion, short half-life, and photo degradation prompting poor bioavailability when it is regulated.…”

Section: Introductionmentioning

confidence: 99%

Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice

Alotaibi

Tousson

El‐Masry

et al. 2020

Environmental Toxicology

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While clinical innovation has improved, cancer or malignant growth stays a genuine medical issue and has been perceived as a significant factor in mortality and morbidity. Current work aimed to define the cardiac defensive effects of curcumin nanoparticles (Cur Nps) against EAC induced cardiac toxicity, injury, and alterations in apoptosis, proliferation, and cytokines immunoreactivity. Forty female mice were aimlessly and equally divided into four groups [Gp1, Control; Gp2, Cur NPs; Gp3, Ehrlich ascites carcinoma (EAC); Gp4, Co-treatment of EAC with Cur NPs (Cur NPs + EAC)]. Serum lactate dehydrogenase (LDH), phosphocreatine kinase (CPK), creatine kinase myoglobin (CK-MB), alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), cholesterol, triglycerides, potassium ions, cardiac injury, P53, vascular endothelial growth factor protein (VEGF), Bax, and tumor necrosis factor alpha (TNFα) expressions were significantly elevated while sodium ions levels were significantly depleted in EAC when compared to control. Co-treatment of EAC with Cur NPs (Cur NPs + EAC) improved these parameters as compared with EAC group. So, our results indicate that; Cur NPs induced protection to the blood and heart tissue during Ehrlich ascites carcinoma.

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A study on Amygdalin's genotoxicological safety and modulatory activity in human peripheral lymphocytes in vitro

Erikel

Yüzbaşıoğlu

Ünal

2023

Environ and Mol Mutagen

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Amygdalin (AMY), a plant secondary metabolite containing nitrile, is a major component of the seeds of Rosaceae family plants. It is known that this compound has many pharmacological activities such as cancer prevention, antipyretic, and cough suppressant. In this study, the genotoxic and modulatory effects of amygdalin were assessed by chromosomal aberration (CA), sister chromatid exchange (SCE), and cytokinesis‐block micronucleus assay (CBMN) assays using human peripheral lymphocytes (HPLs) in the absence and presence of metabolic activator (S9 mix). Lymphocytes were exposed to various concentrations of amygdalin (0.86, 1.72, 3.43, 6.86, and 13.75 μg/mL) alone and in combination with mitomycin‐C (MMC, 0.20 μg/mL) or cyclophosphamide (CP, 12 μg/mL). The mitotic index (MI), replication index (RI), cytokinesis‐block proliferation index (CBPI), and cytostasis were also evaluated to determine cytotoxicity. Amygdalin alone did not exhibit genotoxic and cytotoxic effects at all the tested concentrations both in the absence and presence of the S9 mix. In contrast, amygdalin significantly reduced the frequencies of CA (especially at 48 h treatments), SCE, and MN (except 0.86 μg/mL in pre‐ and simultaneous treatment) induced by MMC in all the tested concentrations and treatment protocols. It has also considerably decreased CP‐induced CA and SCE frequencies at all the concentrations (except 0.86 μg/mL) in simultaneous treatment. This study demonstrated that amygdalin alone was not genotoxic, on the contrary, it has revealed modulatory effects against chemotherapy agents that induced genomic damage in human lymphocytes, suggesting its chemopreventive potential.

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RETRACTED ARTICLE: Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma–induced liver toxicity

Cited by 48 publications

References 51 publications

Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay

Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay

Ehrlich ascites carcinoma as model for studying the cardiac protective effects of curcumin nanoparticles against cardiac damage in female mice

A study on Amygdalin's genotoxicological safety and modulatory activity in human peripheral lymphocytes in vitro

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