Retracted Article: Long noncoding RNA PTPRG-AS1 regulates growth of glioma cells by sponging miR-185-5p

Xu, Chenyang; Li, Zhenjiang; He, Tao; Yuan, Bin; Ding, Bingqian

doi:10.1039/c8ra09546a

Cited by 2 publications

(3 citation statements)

References 31 publications

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“…These results indicated that PTPRG-AS1 serves an indirect role as an oncogene through PRC1. In addition, Xu et al (10) demonstrated that PTPRG-AS1 can regulate the growth of glioma cells by sponging miR-185-5 in vitro.…”

Section: Discussionmentioning

confidence: 99%

“…However, during recent years, increasing evidence has demonstrated that lncRNAs are dysregulated in numerous diseases, especially in cancers, and that they serve crucial role in the regulation of various pathophysiological processes, including cell proliferation, apoptosis, necrosis, and autophagy (5)(6)(7). The lncRNA PTPRG-AS1 has not only been found to be overexpressed in tumor tissues, including breast cancer (8) and ovarian epithelial cancer (9), but has also been demonstrated to be involved in the regulation of radiosensitivity, metastasis and proliferation of tumor cells (10,11). However, the expression of PTPRG-AS1 and its role in osteosarcoma remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Yang

Wen

2021

Oncol Lett

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The present study aimed to determine the expression of the long non-coding RNA PTPRG-AS1 in patients with osteosarcoma, and to explore its role on the prognosis of patients and the process of osteosarcoma cell metastasis. Reverse transcription quantitative-PCR was performed to detect PTPRG-AS1 expression in osteosarcoma tumor tissues and cells (U2OS, SJSA1 and Saos-2), and normal tissues and cells (hFOB1.19). In addition, qPCR and western blotting were also used to detect mRNA and protein expression, respectively, whereas fluorescence in situ hybridization was used to locate the position of PTPRG-AS1 in osteosarcoma cells. Transwell assay was used to determine the migratory and invasive abilities of osteosarcoma cells. The results demonstrated that PTPRG-AS1 was highly expressed in osteosarcoma cells and tissues, which was compared with normal bone cells and adjacent healthy tissues. Furthermore, PTPRG-AS1 expression level in patients with osteosarcoma and lymph node metastasis or distal metastasis was elevated compared with normal tissues. In addition, the results from univariate and multivariate analyses demonstrated that PTPRG-AS1 expression level was significantly associated with Tumor-Node-Metastasis stage (P=0.025), lymph node metastasis (P=0.035) and distant metastasis (P=0.016) in patients with osteosarcoma. PTPRG-AS1 expression level (odd ratio, 3.012; 95% confidence interval, 1.564-4.219) was also considered as an independent risk factor affecting the 5-year survival rate of patients with osteosarcoma. Furthermore, the 5-year overall survival rate of patients with elevated PTPRG-AS1 expression level (56.36%) was significantly lower compared with patients with low PTPRG-AS1 expression level (78.43%). In addition, PTPRG-AS1 knockdown using small interfering RNA significantly decreased the invasive and migratory abilities of osteosarcoma cells in vitro. In summary, PTPRG-AS1 high expression in patients with osteosarcoma may predict the poor prognosis of patients, as PTPRG-AS may have a promoting effect on osteosarcoma cell metastasis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Yang

Wen

2021

Oncol Lett

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“…Similar to the results in Iranian breast cancer cases, PTPRG-AS1 over expression has been reported in Chinese glioma samples compared with matched adjacent normal tissues. Moreover, they showed that the PTPRG-AS1 acts as a ceRNA by sponging miR-185-5p to regulate cell growth [113].…”

Section: Breast Cancermentioning

confidence: 99%

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

2020

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Background: Cancer is associated with various genetic and environmental risk factors. Beside the mutations or aberrant expression of protein-coding genes, the genetic deregulation of non-coding RNAs has also an important role during tumor progression and metastasis. Long non-coding RNAs (lncRNAs) are a class of ncRNAs larger than 200 nucleotides that may function as tumor-suppressor or oncogene. Main body:There is a raising trend of cancer incidence among Iranian population during the last decades. Therefore, it is required to prepare a general population specific panel of genetic markers for the early detection of cancer in this population. The tissue-specific expression characteristics and high stability in body fluids highlight the lncRNAs as efficient diagnostic and prognostic noninvasive biomarkers in cancer. In present review we summarized all of the lncRNAs which have been reported until now in different tumors among Iranian patients. Conclusions:This review paves the way of introducing a population based noninvasive diagnostic panel of lncRNAs for the early detection of tumor cells among Iranian population.

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Retracted Article: Long noncoding RNA PTPRG-AS1 regulates growth of glioma cells by sponging miR-185-5p

Abstract: Previous studies have found that long noncoding RNA (lncRNA) protein tyrosine phosphatase, receptor type, G, antisense (PTPRG-AS1) was upregulated in glioma cells.

Cited by 2 publications

References 31 publications

Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Upregulation of long‑noncoding RNA PTPRG‑AS1 can predict the poor prognosis and promote migration and invasion in patients with osteosarcoma

Long non-coding RNAs as the critical factors during tumor progressions among Iranian population: an overview

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