RETRACTED ARTICLE: Meta-analysis of the effect of percutaneous coronary intervention on chronic total coronary occlusions

Abstract

Background and purposeCoronary chronic total occlusion (CTO) is the last stage of coronary artery atherosclerosis. Percutaneous coronary intervention (PCI) is a therapeutic procedure used to recanalize vessels with total occlusion. However, successful recanalization of CTO is still not optimal, and the key influence factors are still uncertainty. Therefore, a scientific evaluation on the effective of PCI for CTO treatment is necessary.MethodsRelevant studies of PCI treatment for CTO were examined. Data were extracted and assessed by two independent clinical experts. Embase, PubMed and Medline et al. were used as database. The main research key words include “CTO”, “PCI”, “Stent”, “Reopen”, “long-term”, “follow-up” and “outcome”. Quality assessment was carried out according to the Cochrane Handbook. The selected data were pooled and analyzed using fixed-effect model and random-effect model. Heterogeneity was assessed using the I2 test, Q test, L’abbe and Galbraith. Comprehensive Meta -Analysis 2.0 and Metanalysis 1.0 were used for statistics analysis in this research.ResultsA total of 16 articles involving 6695 cases in successful CTO recanalization (CTO success group) and 2370 cases in failed CTO recanalization(CTO failure group) were included in this research. Low CTO success was associated with elder age, previous coronary artery bypass graft surgery (CABG) history, multi-vessel diseases and right coronary artery disease lesion. Six follow-up variables including major adverse cardiac events (MACE), recurrent myocardial infarction (MI), all-cause death, incidence of angina, subsequent CABG and cumulative survival rate were found significantly reduced associated with CTO success.ConclusionsClinical baseline characteristics such as age, previous CABG history and lesion baseline characteristics such as lesion length, multi-vessel diseases might be important factors influencing the successful rate of CTO recanalization. Compared to CTO failure patients, all six follow-up variables showed advantage for CTO success patients.

Procedural failure of chronic total occlusion percutaneous coronary intervention: Insights from a multicenter US registry

“…The clinical characteristics of patients with successful vs. failed CTO PCI was similar. Prior data on the topic has been discordant, with most studies showing no significant differences in clinical characteristics between successful and failed CTO PCI cases . However, Prasad et al reported higher prevalence of smoking and previous myocardial infarction among failed cases in a 1,262 patient CTO registry .…”

Successful revascularization of right coronary artery chronic total occlusion by the antegrade and retrograde approaches

“…With the development of a systematic algorithm for CTO PCI, the success rate of CTO PCI has also clearly improved (7,8). Patients in whom CTO PCI was successful had better outcomes compared with those in whom CTO PCI failed (9). Furthermore, procedural failure was due to the inability to cross the lesion with a guidewire in 70% of cases, or less commonly, in 30% of cases (10), due to a complication.…”

Retraction Note: Meta-analysis of the effect of percutaneous coronary intervention on chronic total coronary occlusions

“…The Publisher and Editor regretfully retract this article [ 1 ] because the peer-review process was inappropriately influenced and compromised. As a result, the scientific integrity of the article cannot be guaranteed.…”