RETRACTED ARTICLE: MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3

Shi, Bingxia; Yan, Wei; Liu, Guolin; Guo, Yanjun

doi:10.1186/s11658-018-0094-0

Cited by 25 publications

(31 citation statements)

References 44 publications

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“…As a novel miRNA, the research focused on miR-488 was limited and reported the downregulation of miR-488 in several human cancers and its low expression significantly correlated with progression, metastasis, and poor survival [5][6][7][8][9] , indicating the tumor-suppressive role of miR-488 in different types of cancers. However, the function and mechanism of miR-488 in breast cancer is still unclear.…”

Section: Discussionmentioning

confidence: 99%

“…The proliferation and invasion abilities of hepatocellular carcinoma cells were also inhibited by the high-level of miR-488 through the downregulation of ADAM9 and lncRNA HULC 6 . In tongue squamous carcinoma, miR-488 could increase the sensitivity of tumor cells to chemotherapy 7 , supposed that miR-488 was involved in the inhibition of the epithelial–mesenchymal transition (EMT) process 8 . Recently, Takaaki et al demonstrated that circulating pre-miRNA-488 in peripheral blood would be a potential biomarker for predicting recurrence of breast cancer 9 .…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas

Yuan

et al. 2020

Cell Death Dis

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As important modulators in multiple physiological processes, microRNAs (miRNAs) have been reported in various malignant tumors, including breast cancer. The current study investigated the function of a new tumor suppressor microRNA, miR-488, and its molecular mechanism of metastasis in breast cancers. CCK8 and transwell assays revealed that the upregulated miR-488 level significantly inhibited the proliferation and migration of breast cancer cells. As a potential downstream gene, the mRNA and protein level of FSCN1 was suppressed by increased miR-488 and vice versa. Luciferase assay showed that miR-488 directly bind to the 3′UTR of FSCN1 and suppressed the translation process of FSCN1. The promoter region of miR-488 was directly bound by Notch3 and promoted the expression of miR-488 transcriptionally. Immunohistochemistry results revealed that in patients with breast cancer, the expression of Notch3 and were negatively correlated with the FSCN1 levels significantly. Therefore, the current finding predicted miR-488 as a tumor suppressor molecule in breast cancer, and demonstrated that Notch3/miR-488/FSCN1 axis is established and involved in regulating the metastasis of breast cancers, providing novel therapeutic targets for patients with breast cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas

Yuan

et al. 2020

Cell Death Dis

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“…Meanwhile, Zhang et al also reports that urothelial cancer associated 1 knockdown significantly suppresses TGFβ1-induced TC cell invasion and EMT by decreasing vimentin and increasing E-cadherin (Zhang et al, 2019). Shi et al discovers that the EMT of TSCC cells is inhibited by ameliorating the expressions of MMP-2 and MMP-9 (Shi et al, 2018). All these data support our point.…”

Section: Discussionmentioning

confidence: 99%

“…It is found that miR-488 is significantly decreased in TSCC tissues and cell lines. Further, knockdown of miR-488 promotes invasion (Shi et al, 2018). Hsa-miR-485-5p reverses epithelial to mesenchymal transition (EMT) and promotes cisplatin-induced cell death by targeting PAK1 in TSCC (Lin et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7

Feng

So²,

Yin

et al. 2019

Front. Pharmacol.

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To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tumor tissues compared with those in the paired paratumor tissues. Further, expression of miR-532-3p was detected in four TSCC cell lines, TSCCA, TCA8113, CAL-27, and SCC-25. The miR-532-3p mimics and inhibitor were transfected into the CAL-27 and TCA8113 cell lines which were the relatively lowest and highest miR-532-3p expressions, respectively. It was found that the overexpression of miR-532-3p suppressed TSCC cell proliferation, migration, invasion, and promoted apoptosis in vitro , whilst the knockdown of miR-532-3p reversed these behaviors. The bioinformatics predicted that CCR7 was a downstream gene of miR-532-3p, which was confirmed via luciferase assay. Following, the decline of CCR7 in the miR-532-3p mimics group and the rise of CCR7 in the miR-532-3p inhibitor group were also verified. In addition, enhanced cell proliferation, migration and invasion induced by CCR7 were partly restrained by miR-532-3p in TSCC cell. Meanwhile, miR-532-3p attenuated tumourigenesis in vivo due to the reduction of tumor volume and Ki-67 positive rate and the increase of apoptotic cells. Taken together, these findings reveal a pivotal role for the miR-532-3p/CCR7 axis in regulating TSCC, and this novel axis could be suitable for therapeutic intervention in TSCC disease.

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“…This interaction results in translational suppression and/or mRNA degradation. miRNAs are capable of oncogenic or tumor-suppressive actions in TScc by modulating the processes associated with TScc initiation and progression, such as cell proliferation, cell cycle, apoptosis, angiogenesis Long non-coding RNA PRNCR1 exerts oncogenic effects in tongue squamous cell carcinoma in vitro and in vivo by sponging microRNA-944 and thereby increasing HOXB5 expression and metastasis (21)(22)(23). Therefore, further investigation into the functions of specific lncRNAs and miRNAs in TSCC may highlight promising targets for treating TScc.…”

Section: Introductionmentioning

confidence: 99%

Long non‑coding RNA PRNCR1 exerts oncogenic effects in�tongue squamous cell carcinoma in�vitro and in�vivo by sponging microRNA‑944 and thereby increasing HOXB5�expression

Zou

et al. 2020

Int J Mol Med

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A long non-coding RNA (lncRNA) called prostate cancer-associated non-coding RNA 1 (PRNCR1) serves crucial roles in the aggressive phenotypes of colorectal cancer and non-small cell lung cancer. However, there is little research on the expression profile, clinical value and detailed functions of PRNCR1 in tongue squamous cell carcinoma (TScc). The aim of the present study was to determine PRNCR1 expression in TScc and to examine the involvement of PRNCR1 in TScc progression. The molecular mechanisms behind the oncogenic effects of PRNCR1 in TScc cells were also investigated. PRNCR1 was revealed to be upregulated in TScc tumors and cell lines. The high PRNCR1 expression showed a significant correlation with tumor size, clinical stage, lymph node metastasis, and shorter overall survival times among patients with TScc. A PRNCR1-knockdown reduced TScc cell proliferation, migration and invasion, and increased apoptosis in vitro. Additionally, the PRNCR1-knockdown slowed down in vivo tumor growth of TScc cells. With regards to the mechanism, PRNCR1 acted as a competing endogenous RNA on microRNA-944 (miR-944) in TScc cells, and the effects of the PRNCR1-knockdown were reversed by an miR-944-knockdown. HOXB5 was validated as a direct target gene of miR-944 in TScc cells, and HOXB5 expression was found to be positively regulated by PRNCR1. Furthermore, resumption of HOXB5 expression reversed the tumor-suppressive actions of miR-944 in TScc cells. In conclusion, PRNCR1 acts as an oncogenic lncRNA in TScc through the upregulation of HOXB5 by sponging miR-944, thereby indicating a potential therapeutic target in TScc.

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RETRACTED ARTICLE: MicroRNA-488 inhibits tongue squamous carcinoma cell invasion and EMT by directly targeting ATF3

Cited by 25 publications

References 44 publications

MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas

MicroRNA-488 inhibits proliferation and motility of tumor cells via downregulating FSCN1, modulated by Notch3 in breast carcinomas

MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7

Long non‑coding RNA PRNCR1 exerts oncogenic effects in�tongue squamous cell carcinoma in�vitro and in�vivo by sponging microRNA‑944 and thereby increasing HOXB5�expression

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