RETRACTED ARTICLE: Overexpression of interleukins IL-17 and IL-8 with poor prognosis in colorectal cancer induces metastasis

Mohammadi, Mohsen; Kaghazian, Maria; Rahmani, O.; Ahmadi, Koorosh; Ziari, Katayoun; Talebreza, Amir

doi:10.1007/s13277-015-4628-z

Cited by 10 publications

(8 citation statements)

References 35 publications

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“…High IL-22 concentrations and the elevated expression of CD38 may be implicated in the synergetic stimulation of genes involved in proliferation and programmed cell death. Elevated levels are connected with poor outcome in B-CLL patients [182], and it has been reported as a prognostic biomarker in cancers [183,184].…”

Section: Effects Of Cytokines On the Onset Progression And Complicamentioning

confidence: 99%

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and are decisive for its onset, evolution, and therapeutic response. Modifications in the cytokine balance could support the growth of the leukemic clone via a modulation of cellular proliferation and apoptosis, as some cytokines have been reported to be able to affect the life of B-CLL cells in vivo. In this review, we will examine the role played by cytokines in the cellular dynamics of B-CLL patients, interpret the contradictions sometimes present in the literature regarding their action, and evaluate the possibility of manipulating their production in order to intervene in the natural history of the disease.

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Section: Effects Of Cytokines On the Onset Progression And Complicamentioning

confidence: 99%

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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“…Some clinical investigations have also indicated significantly decreased disease-free survival and overall survival of CRC patients with high CXCL8 expression, suggesting a correlation between elevated CXCL8 expression and the poor survival rate among CRC patients. 80 Moreover, absence of CXCL8 expression in epithelial cells might be a factor indicating a good prognosis. 79…”

Section: Cxcl8 and Its Specific Receptors In Colorectal Cancermentioning

confidence: 99%

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

Łukaszewicz-Zając¹,

Pączek²,

Mroczko³

et al. 2020

CMAR

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Every year, almost 2 million people develop colorectal cancer (CRC), which makes it the fourth most common malignancy worldwide. It is also estimated that approximately 48% of CRC patients will die from the disease. Thus, noninvasive and accurate methods for early detection and prevention of CRC are sorely needed. It is suggested that C-X-C motif ligand 1 (CXCL1) and C-X-C motif ligand 8 (CXCL8) as well as their cognate receptors can mediate tumor growth, proliferation, survival, neoangiogenesis and metastasis of malignant cells, including CRC. However, little is known about the clinical significance of these proteins as potential biomarkers for CRC. Therefore, in our review, we performed a comprehensive literature search using the PubMed database to identify original articles that investigated whether CXCL1 and CXCL8 and their receptors play a role in CRC pathogenesis. In summary, our review highlighted the potential significance of CXCL1/CXCR2 and CXCL8/CXCR1,-2 in the diagnosis and progression of CRC as well as indicated their potential therapeutic significance. However, given the non-specific nature of analyzed chemokines and a small number of studies concerning the assessment of blood concentration of these proteins in CRC patients, investigations need to be continued in the future before selected chemokines could be established as biomarkers for CRC.

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“…Tumor metastasis is a major cause of mortality in CRC [ 3 ]. Although many cell growth and metastasis-related genes were found, the molecular mechanisms that suppress tumor cell growth, migration and invasion are largely unknown [ 4 – 6 ]. Recently, there has been an attention on the characterization of microRNAs in oncogenesis and tumor suppressing.…”

Section: Introductionmentioning

confidence: 99%

miR-133b suppresses metastasis by targeting HOXA9 in human colorectal cancer

Xiao

Liu

et al. 2017

Oncotarget

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Functions and mechanisms of microRNA (miRNA) involved in colorectal cancer (CRC) metastasis are largely unknown. Here, a miRNA microarray analysis was performed in CRC primary tissues and metastatic hepatic tissues to disclose crucial miRNA involved in CRC metastasis. MiR-133b was decreased and negatively correlated with metastasis in CRC. Overexpression of miR-133b significantly suppressed metastasis of CRC in vitro and in vivo. HOXA9 was identified as a direct and functional target of miR-133b. In addition, HOXA9 was negatively correlated with miR-133b and promoted CRC malignant progress. Moreover, miR-133b decreased HOXA9 expression, and subsequently downregulated ZEB1 and upregulated E-cadherin expression. Intriguingly, lower miR-133b and higher HOXA9 expression significantly contributed to poorer outcomes in CRC patients. Multivariate analysis indicated that miR-133b was an independent and significant predictor of CRC patient overall survival. In conclusion, we newly determined that miR-133b targeted the HOXA9/ZEB1 pathway to promote tumor metastasis in CRC cells. This axis provided insights into the mechanism underlying miRNA regulation of CRC metastasis and a novel therapeutic target for CRC treatment.

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RETRACTED ARTICLE: Overexpression of interleukins IL-17 and IL-8 with poor prognosis in colorectal cancer induces metastasis

Cited by 10 publications

References 35 publications

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

<p>The Significance of CXCL1 and CXCL8 as Well as Their Specific Receptors in Colorectal Cancer</p>

miR-133b suppresses metastasis by targeting HOXA9 in human colorectal cancer

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