RETRACTED ARTICLE: Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection

Abstract

Background The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection. Methods Fifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded. Results Oxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01). Conclusion Oxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine. Name of the registry: Chinese Clinical Trial Registry Trial registration number: ChiCTR1900021870 URL of trial registry record:http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4 Date of registration: 2019/3/13 0:00:00

Comparison of the analgesic effects of oxycodone vs. sufentanil on postoperative pain after laparoscopic gallbladder-preserving cholecystolithotomy: a prospective randomized controlled trial

“…Most importantly, the same analgesic effect can be achieved with a smaller dose ( 12 ). A clinical study found that morphine and oxycodone exhibited comparable efficacy in addressing skin and muscle pain, whereas oxycodone provided better analgesia for esophageal pain caused by thermal and electrical stimulation ( 13 ). In terms of acute pain efficacy, oxycodone is administered at doses less than morphine 2 h after abdominal surgery because it can rapidly cross the blood-brain barrier into the brain.…”

The optimal dose of oxycodone in PCIA after laparoscopic surgery for gastrointestinal cancer in elderly patients: A randomized controlled trial

“…κ-opioid receptor plays an important role in the mediation of visceral pain (6). Oxycodone, a dual agonist of μ and κ receptors (14), has been shown to provide effective analgesia for acute postoperative pain (15,16), especially visceral pain. However, the safe and effective dose of oxycodone in PCIA following laparoscopic surgery for gastrointestinal cancer in elderly patients has not been determined.…”

Clinical Update on Patient-Controlled Analgesia for Acute Postoperative Pain

“…Several risk factors for high postoperative pain scores have been established [6,7]. Nearly all types of surgery that yield high postoperative pain can be treated with IV-PCA in the acute phase; examples of such surgeries include spine and other complex orthopedic surgeries, such as knee and hip [15], open abdominal [16] and non-ambulatory laparoscopic surgery [17]; and thoracic [18], major cervicofacial and reconstruction surgeries [19], including breast surgeries [20]. In addition to initial severe postoperative pain, some surgeries can also yield chronic postoperative pain such as cardiac [21], knee [22] shoulder [23] and hip pain [24].…”