RETRACTED ARTICLE: Physcion 8-O-β-glucopyranoside mediates the NLRP3-associated pyroptosis and cell metastasis in the human osteosarcoma cells via ER stress activation

Tian, Baogang; Hua, Zhen; Wang, Zhijiong; Wang, Jianwei

doi:10.1007/s00210-020-01836-y

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…In addition, in vivo experiments showed that PG reduced the growth and invasion of tumor in osteosarcoma mouse models. These results suggest the possible mechanism of the effect about PG in human osteosarcoma cells and provide a new drug choice for the clinical treatment of osteosarcoma ( 91 ).…”

Section: Pyroptosis With Tumorsmentioning

confidence: 75%

Pyroptosis, a New Breakthrough in Cancer Treatment

Wei

et al. 2021

Front. Oncol.

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The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response. With constant research in recent years, more and more evidences show that pyroptosis is closely related to the occurrence and development of tumors. The treatment of tumors is a big problem worldwide. We focus on whether we can discover new potential tumor markers and new therapeutic targets from the mechanism. If we can understand the mechanism of pyroptosis and clear the relationship between pyroptosis and the development of tumors, this may provide a new reference for clinical cancer treatment.

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Section: Pyroptosis With Tumorsmentioning

confidence: 75%

Pyroptosis, a New Breakthrough in Cancer Treatment

Wei

et al. 2021

Front. Oncol.

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“…The first article on the anti-cancer properties of PG was published in December 2014 by Xie and Yang. 14 To date, a total of 20 papers have been published, of which 13 papers (65%) [15][16][17][18][19][20][21][22][23][24][25][26][27] were retracted (Table 1). The remaining seven papers (35%) 14,[28][29][30][31][32][33] were non-retracted.…”

Section: Pgmentioning

confidence: 99%

“…Most of the retraction notices stated that one or more figures displayed similarities with those of previously published papers. 15,[17][18][19][20][21][22]27 The authors neither provided the raw data for substantiation, nor provided explanations for the similarities, nor cited the references in the reuse of data. Other reasons include the extensive copying of data and text from another source 16 and the scientific integrity of the paper has been compromised.…”

Section: Pgmentioning

confidence: 99%

A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice

Chan

2023

Ind. J. Pharm. Edu. Res

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Background:The number of retractions of journal articles has sharply increased in recent decades. Objectives: In this case report, excessive retracted publications on the anti-cancer properties of physcion 8-O-β-D-glucopyranoside (PG) in recent years were presented and discussed, in comparison with those of physcion. A literature search for technical and review papers on the anti-cancer properties of PG and physcion was conducted via Google Scholar and PubMed. PG and physcion are bioactive anthraquinones. In this study, 13 out of 20 papers (65%) and 3 out of 16 papers (19%) on the anti-cancer properties of PG and physcion were retracted, respectively. The main reason for retraction was the copying of figures from previously published papers. None of the notices of retractions highlighted research malpractice. The word 'RETRACTION' printed in red on every page of retracted articles may be a more effective deterrent for authors than retraction notices. Conclusion: This case report exemplifies the retraction of publications on the anti-cancer properties of PG and physcion as a form of remedy for research malpractice, only if the process is properly implemented.

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Novel pyroptosis-related lncRNAs and ceRNAs predict osteosarcoma prognosis and indicate immune microenvironment signatures

Yang,

Zheng,

et al. 2023

Heliyon

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RETRACTED ARTICLE: Physcion 8-O-β-glucopyranoside mediates the NLRP3-associated pyroptosis and cell metastasis in the human osteosarcoma cells via ER stress activation

Cited by 4 publications

References 39 publications

Pyroptosis, a New Breakthrough in Cancer Treatment

Pyroptosis, a New Breakthrough in Cancer Treatment

A Case Report of Retracted Publications in Pharmaceutical Science as a Remedy for Research Malpractice

Novel pyroptosis-related lncRNAs and ceRNAs predict osteosarcoma prognosis and indicate immune microenvironment signatures

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