RETRACTED ARTICLE: Strontium doped bioglass
         incorporated hydrogel-based scaffold for amplified bone tissue regeneration

Manoochehri, Hamed; Ghorbani, Masoud; Moghaddam, Mehrdad Moosazadeh; Nourani, Mohammad Reza; Makvandi, Pooyan; Sharifi, Esmaeel

doi:10.1038/s41598-022-14329-0

Cited by 41 publications

(25 citation statements)

References 90 publications

(107 reference statements)

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“…Furthermore, an in vitro study researched by Baheiraei et al [ 70 ] showed that gelatin-BGs/Sr scaffolds can inhibit the vitality of Escherichia coli and some Staphylococcus aureus, thereby preventing infection and improving bone regeneration. Sr-BGs with high mechanical strength and better cell differentiation efficiency are a suitable choice for bone defect repair materials [ 71 ]. Fiorilli et al [ 72 ] confirmed the osteogenic effect of Sr incorporation into BGs by analyzing the expression of COLⅠa1, RANKL, OPG, and ALP.…”

Section: Biomaterials Compound With Srmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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Bone defect disease causes damage to people’s lives and property, and how to effectively promote bone regeneration is still a big clinical challenge. Most of the current repair methods focus on filling the defects, which has a poor effect on bone regeneration. Therefore, how to effectively promote bone regeneration while repairing the defects at the same time has become a challenge for clinicians and researchers. Strontium (Sr) is a trace element required by the human body, which mainly exists in human bones. Due to its unique dual properties of promoting the proliferation and differentiation of osteoblasts and inhibiting osteoclast activity, it has attracted extensive research on bone defect repair in recent years. With the deep development of research, the mechanisms of Sr in the process of bone regeneration in the human body have been clarified, and the effects of Sr on osteoblasts, osteoclasts, mesenchymal stem cells (MSCs), and the inflammatory microenvironment in the process of bone regeneration have been widely recognized. Based on the development of technology such as bioengineering, it is possible that Sr can be better loaded onto biomaterials. Even though the clinical application of Sr is currently limited and relevant clinical research still needs to be developed, Sr-composited bone tissue engineering biomaterials have achieved satisfactory results in vitro and in vivo studies. The Sr compound together with biomaterials to promote bone regeneration will be a development direction in the future. This review will present a brief overview of the relevant mechanisms of Sr in the process of bone regeneration and the related latest studies of Sr combined with biomaterials. The aim of this paper is to highlight the potential prospects of Sr functionalized in biomaterials.

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Section: Biomaterials Compound With Srmentioning

confidence: 99%

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

et al. 2023

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“…Antibacterial systems can enhance the tissue regeneration process by inhibiting pathogenic microorganisms 28,29 . The antibacterial activity of the double-layered nanofibrous mat with and without SSD against S. aurous and P. aeruginosa is shown in Fig.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats

Nejaddehbashi

Rafiee

Orazizadeh

et al. 2023

Sci Rep

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Diabetic wounds are problematic to heal owing to microbial infections as well as decreased proliferation and high concentrations of reactive oxygen species. In this study, a double-layered nanofibrous mat containing grape seed extract (GSE) and silver sulfadiazine (SSD) was fabricated. A synthetic biodegradable polymer, e.g., polycaprolactone (PCL), and a natural material (i.e., collagen) were employed as wound dressing substances. The results showed that GSE possesses antioxidant activity which can be helpful in reducing free radicals. The platform exhibited antibacterial activity against gram-positive and -negative bacteria. The double-layered nanofibrous mat containing GSE and SSD not only was not toxic but also amplified the cell proliferation compared to a pure mat, showing the effect of plant extract. After induction of a round wound, the animals were divided into three groups, namely (1) normal group (receiving + GSE/-GSE nanofiber), (2) diabetic group (receiving + GSE/-GSE nanofiber), and (3) control group (receiving gauze). In vivo evaluation demonstrated no significant differences in the healing process of normal rats. Surprisingly, fully repaired skin was observed on day 14 in the double-layered nanofibrous mat containing GSE in the normal and diabetic groups whereas the wound of diabetic rats treated with pure mat was not completely healed. The macroscopic and microscopic results after 14 days showed the following order in wound repair: Normal/ + GES > Diabetic/ + GSE > Normal/-GES > Diabetic/-GSE > control (with gauze) (p < 0.05). Accordingly, the double-layered nanofibrous mat containing GSE and SSD used in the present study could be considered as a suitable wound dressing in order to shorten healing time and prevent infection during the wound healing process.

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“…Zare et al reported strontium-doped BAG nanofibers for bone tissue engineering applications . Manoochehri et al prepared a strontium-doped bioglass-incorporated hydrogel-based scaffold for amplified bone tissue regeneration . However, these BAG-based hydrogel scaffolds often require invasive surgical procedures, excellent defect margin adaptation, and complete defect filling owing to their nature of non-injectability…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Pal

Karmakar

Vel

et al. 2023

ACS Appl. Bio Mater.

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Recently, injectable hydrogels have attracted much interest in tissue engineering (TE) applications because of their controlled flowability, adaptability, and easy handling properties. This work emphasizes the synthesis and characterizations of bioactive glass (BAG) nanoparticle-reinforced poly(ethylene glycol) (PEG)- and poly(N-vinylcarbazole) (pNVC)-based minimally invasive composite injectable hydrogel suitable for bone regeneration. First, the copolymer was synthesized from a combination of PEG and pNVC through reversible addition–fragmentation chain-transfer (RAFT) polymerization and nanocomposite hydrogel constructs were subsequently prepared by conjugating BAG particles at varying loading concentrations. Gel permeation chromatography (GPC) analysis confirmed the controlled nature of the polymer. Various physicochemical characterization results confirmed the successful synthesis of copolymer and nanocomposite hydrogels that showed good gelling and injectability properties. Our optimal nanocomposite hydrogel formulation showed excellent swelling properties in comparison to the copolymeric hydrogel due to the presence of hydrophilic BAG particles. The bone cell proliferation rate was found to be evidently higher in the nanocomposite hydrogel than in the copolymeric hydrogel. Moreover, the enhanced level of ALP activity and apatite mineralization for the nanocomposite in comparison to that for the copolymeric hydrogel indicates accelerated in vitro osteogenesis. Overall, our study findings indicate BAG particle-conjugated nanocomposite hydrogels can be used as promising grafting materials in orthopedic reconstructive surgeries complementary to conventional bone graft substitutes in cancellous bone defects due to their 3D porous framework, minimal invasiveness, and ability to form any desired shape to match irregular bone defects.

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RETRACTED ARTICLE: Strontium doped bioglass incorporated hydrogel-based scaffold for amplified bone tissue regeneration

Cited by 41 publications

References 90 publications

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

Antibacterial and antioxidant double-layered nanofibrous mat promotes wound healing in diabetic rats

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

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