RETRACTED ARTICLE: Takotsubo (stress) cardiomyopathy in childhood

Topal, Yaşar; Topal, Hatice; Doğan, Cem; Tiryaki, Sibel; Biteker, Murat

doi:10.1007/s00431-019-03536-z

Cited by 17 publications

(19 citation statements)

References 1 publication

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“…Our study from a large national paediatric discharge database shows higher prevalence of takotsubo cardiomyopathy in males, unlike previously published studies in which takotsubo cardiomyopathy is equally distributed or more prevalent in female children [14][15][16] and adult women 5 . The median ages in previously published studies were 8-9 years compared to our study in which more than 90% of the patients were in the age group of 12-20 years 15,16 . The differences in gender and age distribution between this study and those previously published may be because our data represent a large, national sample, whereas previously published studies were limited to case series or single institution studies.…”

Section: Discussioncontrasting

confidence: 99%

“…Currently, there is no specific guideline regarding the diagnosis and management of takotsubo cardiomyopathy in children. Although takotsubo cardiomyopathy is more prevalent in the adult population, it may occur in children with comparable presentation, triggers, EKG, and imaging findings to those of adults 14,15 . Paediatric studies have demonstrated complete recovery of ventricular function between 3 days and 3 months of presentation 14,15 .…”

Section: Discussionmentioning

confidence: 98%

“…However, multiple studies in adults have demonstrated an association between anxiety, depression, or mood disorders with takotsubo cardiomyopathy 5,[17][18][19][20][21] . Emotional or physical stress is a well-established trigger for the development of takotsubo cardiomyopathy 5,14,15 . Events that have been associated with takotsubo cardiomyopathy in adults and children include loss of a family member, motor vehicle accident, public speaking, fear of procedure, tragic news, extreme excitement or surprise, arguments, sepsis, surgery, competition, and drug abuse 5,14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…Emotional or physical stress is a well-established trigger for the development of takotsubo cardiomyopathy 5,14,15 . Events that have been associated with takotsubo cardiomyopathy in adults and children include loss of a family member, motor vehicle accident, public speaking, fear of procedure, tragic news, extreme excitement or surprise, arguments, sepsis, surgery, competition, and drug abuse 5,14,15 . Stress (physical, psychological, emotional) is a common phenomenon in all these conditions.…”

Section: Discussionmentioning

confidence: 99%

“…In 2005, a study described the association of takotsubo cardiomyopathy with sepsis in adults 8 . Few case reports and case series in paediatrics have reported sepsis to be a trigger for takotsubo cardiomyopathy 15 . The exact mechanism of sepsis-induced takotsubo cardiomyopathy is uncertain.…”

Section: Discussionmentioning

confidence: 99%

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Takotsubo cardiomyopathy in children

et al. 2020

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Objective: To explore the epidemiology and outcomes of takotsubo cardiomyopathy in children. Methods: A retrospective analysis of the Healthcare Cost and Utilization 2012 and 2016 Kids’ Inpatient Database was performed. Patients admitted with the diagnosis of takotsubo cardiomyopathy in the age group of 1 month–20 years were identified using International Classification of Diseases (ICD)-9 code 429.83 and ICD-10 code I51.81. Results: Among a total of 4,860,859 discharges, there were 153 with the diagnosis of takotsubo cardiomyopathy (3.1 per 100,000 discharges). Among patients with takotsubo cardiomyopathy, 55.0% were male, 62.4% were white, and 16.7% were black. Eighty-nine percent of patients were between 12 and 20 years. Psychiatric diagnosis was documented in 46% and substance use disorder in 36.2%. Sepsis was documented in 22.8% of patients. The median length of stay was 5 days (interquartile range: 2.7–15), and median total charges were $75,080 (interquartile range: 32,176–198,336). The overall mortality for takotsubo cardiomyopathy was 7%. On multivariable regression analysis, mortality was higher in the presence of anoxic injury (odds ratio = 34.42, 95% confidence interval: 4.85–320.11, p = 0.00). Conclusions: Takotsubo cardiomyopathy is uncommon in children and carries a mortality rate of 7%. Most children with takotsubo cardiomyopathy are adolescent males, many of whom have psychiatric disorder or substance use disorder or both. Takotsubo cardiomyopathy should be considered in the differential diagnosis for patients who present with cardiac dysfunction and have underlying psychiatric disorders or drug abuse.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Takotsubo cardiomyopathy in children

et al. 2020

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Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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Takotsubo cardiomyopathy (TCM), characterized by transient left ventricular dysfunction, was first reported in Japan in 1990. Current research suggests that TCM can be affected by conventional cardiovascular factors such as hypertension (HTN), diabetes, hyperlipidemia (HLD), and obesity. Despite the increasing interest in this disease, research on TCM remains limited. Conventional cardiovascular factors are clinically related to the outcome of TCM. We reviewed the publications published in PubMed database between January 01 2010 and January 15 2021, and summarized the most current available evidence on the correlation between TCM and the conventional cardiovascular factors. TCM patients are predominantly postmenopausal women. Men and young patients are less commonly seen, but are prone to acute adverse complications and poor prognosis. HTN is common in patients with recurrent TCM. Existing evidence suggests that obesity and chronic kidney disease are related to poor prognosis in TCM. HLD is reported to be associated with fewer complications, though current evidence is limited. Finally, the relationship between diabetes and TCM prognosis is ambivalent. Current evidence suggests conventional cardiovascular risk factors are associated with the outcome of TCM, especially with mortality and complications. More prospective studies are needed to clarify the relationship between each risk factor and the prognosis of TCM.

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