RETRACTED ARTICLE: The novel long non-coding RNA LATS2-AS1-001 inhibits gastric cancer progression by regulating the LATS2/YAP1 signaling pathway via binding to EZH2

Sun, Dan; Wang, Ying; Wang, Huan

doi:10.1186/s12935-020-01285-w

Cited by 12 publications

(6 citation statements)

References 50 publications

(53 reference statements)

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“…The results demonstrated that YAP1 and TEAD1 were highly expressed in osteosarcoma cells and tissues, especially in Saos-2 cells. Consistently, previous studies have demonstrated that YAP1 is implicated in tumorigenesis, facilitating the progression of a number of types of cancer including gastric, liver and peritoneal cancer ( 24 – 26 ), whereas TEAD1 expression is upregulated in various types tumor such as medulloblastoma, renal and gastric cancer, suggesting a tumor-promoting role for TEADs ( 27 , 28 ).…”

Section: Discussionsupporting

confidence: 83%

Verteporfin suppresses osteosarcoma progression by targeting the Hippo signaling pathway

Yang

Jiang

et al. 2021

Oncol Lett

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Verteporfin (VP) is a specific inhibitor of yes-associated protein 1 (YAP1) that suppresses tumor progression by inhibiting YAP1 expression. The present study aimed to determine the inhibitory effect of VP on osteosarcoma and the underlying mechanism of its anticancer effects. Cell viability, cell cycle and apoptosis and cell migration and invasion were analyzed using the MTT assay, flow cytometry, wound healing assay and Transwell assay, respectively. Expressions of YAP1 and TEA domain transcription factor 1 (TEAD1) were measured using reverse transcription-quantitative PCR and western blotting, while their interaction was identified by the co-immunoprecipitation assay. In vivo mouse xenograft experiments were performed to evaluate the effect of VP on osteosarcoma growth. The results demonstrated that YAP1 and TEAD1 were highly expressed in osteosarcoma cells and tissues, whereas VP significantly downregulated the expression levels of YAP1 and TEAD1 in the osteosarcoma cell line Saos-2 compared with those in untreated control cells. In addition, compared with those in the control group, VP suppressed the viability, migration and invasion, induced cell cycle arrest in the G1 phase and promoted apoptosis in Saos-2 cells. In addition, VP inhibited mouse xenograft tumor growth in vivo compared with that observed in the control group. Notably, VP downregulated the levels of CYR61 expression in Saos-2 cells, whereas CYR61 overexpression mitigated the inhibitory effects of VP on osteosarcoma cells, as indicated by the increased viability and reduced apoptotic rates in Saos-2 cells overexpressing CYR61 compared with those in the control group. In summary, VP suppressed osteosarcoma by downregulating the expression of YAP1 and TEAD1. Additionally, CYR61 may mediate the effects of VP on osteosarcoma progression.

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Section: Discussionsupporting

confidence: 83%

Verteporfin suppresses osteosarcoma progression by targeting the Hippo signaling pathway

Yang

Jiang

et al. 2021

Oncol Lett

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“…By contrast, the miR-93-5p inhibitor expedited the Hippo pathway in HP + GC cells by elevating LATS2 protein expression [29]. Mechanistically, overexpression of LATS2-AS1-001 has been indicated to induce LATS2 and YAP1 phosphorylation via binding to EZH2 [30]. Still, the detailed mechanism behind the LATS2-mediated Hippo pathway in GC awaits further validation.…”

Section: Discussionmentioning

confidence: 99%

Upregulation of microRNA-650 by PBX1 is correlated with the development of Helicobacter pylori-associated gastric carcinoma

Liu¹,

Wang²,

Li³

et al. 2021

neo

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Helicobacter pylori (HP) infection induces the development of gastric carcinoma (GC), one of the most frequent and fatal cancers worldwide, via a progressive cascade. The roles of microRNAs (miRNAs) involved in the cascade and the behind mechanisms, however, are still unclear. This study was designed to investigate the expression of miR-650, a well-recognized oncogenic miRNA in GC samples and to analyze the associations between this miRNA and HP infection, and the molecular mechanism. Following miRNA-and mRNA-based microarray analyses, miR-650, pre-B-cell leukemia transcription factor 1 (PBX1), and LATS2 were filtered as targets. After that, function assays were implemented to assess their function in GC cells. miR-650 was upregulated in HP+ tissues and cells, and inhibition of miR-650 attenuated cell proliferation, invasion, migration, yet enhanced apoptosis. PBX1 was overexpressed in HP+ tissues and cells and promoted miR-650 transcription. Overexpression of PBX1 abrogated the effect of the miR-650 inhibitor on GC cells. miR-650 targeted LATS2, and LATS2 was poorly expressed in HP+ tissues and cell lines. Simultaneous knockdown of miR-650 and LATS2 reduced GC cell apoptosis. These results display that upregulation of miR-650 induced by HP infection and PBX1 dampens LATS2 in GC cells, potentially offering novel intervention targets for GC.

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“…Compelling studies have observed that lncRNAs participate in many cell biological processes, including carcinogenesis and development [ 32 – 34 ]. For instance, Sun et al [ 35 ]. proved that lncRNA LATS2-AS1-001 suppressed GC development by modulating the YAP1/LATS2 pathway by binding to EZH2.…”

Section: Discussionmentioning

confidence: 99%

MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma

Liu

Lin

et al. 2021

Aging

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Emerging studies have noted that dysregulated lncRNAs are implicated in cancer progression and tumorigenesis. We first showed that MSC-AS1 was overexpressed in gastric cancer (GC) cells (HGC-27, MKN-45, SGC-7901 and MGC-803 cells) compared with GES cells. We observed that MSC-AS1 was upregulated in GC specimens compared with paired normal specimens. MSC-AS1 increased cell growth and cycle progression. Moreover, the overexpression of MSC-AS1 enhanced the secretion of the inflammatory mediators IL-1β, IL-6 and TNF-α. We found that the overexpression of MSC-AS1 inhibited the expression of miR-142-5p in HGC-27 cells. We noted that DDK5 was a target gene of miR-142-5p. The overexpression of miR-142-5p suppressed the luciferase activity of wild-type DDX5, but the luciferase activity of the mutant DDX5 was not changed. We showed that miR-142-5p was downregulated in GC specimens compared with paired normal specimens. MSC-AS1 expression was inversely correlated with miR-142-5p expression in GC specimens. MSC-AS1 induced cell growth, cell cycle progression and inflammatory mediator secretion by modulating DDX5. These results showed that MSC-AS1 functions as a key oncogene in the development of GC.

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RETRACTED ARTICLE: The novel long non-coding RNA LATS2-AS1-001 inhibits gastric cancer progression by regulating the LATS2/YAP1 signaling pathway via binding to EZH2

Cited by 12 publications

References 50 publications

Verteporfin suppresses osteosarcoma progression by targeting the Hippo signaling pathway

Verteporfin suppresses osteosarcoma progression by targeting the Hippo signaling pathway

Upregulation of microRNA-650 by PBX1 is correlated with the development of Helicobacter pylori-associated gastric carcinoma

MSC-AS1 induced cell growth and inflammatory mediators secretion through sponging miR-142-5p/DDX5 in gastric carcinoma

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