RETRACTED: Association of biochemical markers with the severity of pre‐eclampsia

Maged, Ahmed M.; Aid, Gamal; Bassiouny, Nehal; El-Din, Doaa S Salah; Dahab, Sherif; Ghamry, Nevein Kamal

doi:10.1002/ijgo.12029

Cited by 21 publications

(18 citation statements)

References 16 publications

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“…This is in agreement with Maged et al 2016 study that showed significant difference between women with severe preeclampsia and women in the other two groups (mild and control) in terms of maternal complications such as HELLP syndrome and eclampsia. Also, this is in agreement with Singh et al 2016 study that showed that HELLP syndrome was the most common maternal complication seen in patients with preeclampsia, whereas pulmonary edema was seen in 3.6% of patients and maternal mortality rate was 1.8% [26,27] .…”

Section: Discussionsupporting

confidence: 91%

Relation of VEGF to the risk, severity and prognosis of preeclampsia

Awad

El-Hamedi

2019

Evidence Based Women's Health Journal

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Objective: The aim of this work was to find out if serum level of vascular endothelial growth factor shows changes with the onset of preeclampsia that could be used as predictor for preeclampsia. Patients and Methods: This study included 60 primigravidae women divided into three groups, group (I) included 20 normal women, group (II) included 20 women with mild preeclampsia and group (III) included 20 women with severe preeclampsia.VEGF was measured in all groups and compared Results: VEGF concentrations measured in severe preeclampsia group were significantly higher than mild preeclampsia group and control group. Thus, VEGF concentrations could be used as a predictor for diagnosis and follow up of severity of preeclampsia. VEGF had significant value for discrimination between patients with PE (mild and severe) and controls with cutoff value >632.4 ng/l which had a sensitivity of (82.5%) and specificity of (85%). Also, serum VEGF concentration for discrimination between patients with severe PE and those with mild or no PE was >1335.5 ng/l with specificity of (92.5%) and sensitivity of (90%). VEGF had significant value for prediction of adverse fetal outcomes with cutoff value >741.5 ng/l which had a sensitivity of (95.65%) and specificity of (72.97%). Conclusion: According to the previous data obtained, serum VEGF level can be used as a predictor for preeclampsia.

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Section: Discussionsupporting

confidence: 91%

Relation of VEGF to the risk, severity and prognosis of preeclampsia

Awad

El-Hamedi

2019

Evidence Based Women's Health Journal

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“…A total of 60 pregnant women at 26–38 weeks of gestation, with pregnancies complicated by severe preeclampsia (29 women with early-onset preeclampsia and 31 women with late-onset preeclampsia) and 65 pregnant women with normotensive, uncomplicated third-trimester pregnancies were included in the study. Blood pressure had been measured on each pregnant patient's arm supported and positioned at the level of her heart on two occasions at least 4 hours apart, with using the first Korotkoff sound for evaluation of the systolic blood pressure and the fifth for assessment of the diastolic blood pressure [ 1 ].…”

Section: Methodsmentioning

confidence: 99%

“…Although there have been extensive studies of preeclampsia, its aetiology remains unclear [ 1 – 6 ]. However, it is widely accepted that shallow placentation and impaired spiral arteries precede an increase in secretion of antiangiogenic factors and endothelial cells dysfunction, which are underlying mechanisms of preeclampsia [ 2 – 4 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia

Laskowska

2017

BioMed Research International

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Objective The aim of this study was to determine whether maternal serum matrix metalloproteinases 2, 3, 9, and 13 levels differ in early- and late-onset preeclampsia and uncomplicated pregnancies. Patients and Methods The study was carried out in 125 pregnant women (29 with early-onset preeclampsia; 31 preeclamptic patients with late-onset preeclampsia; and 65 healthy pregnant controls). Levels of MMP-2, MMP-3, MMP-9, and MMP-13 were measured in the maternal serum using an enzyme-linked immunosorbent assay. Results Maternal serum MMP-2 levels in both the groups of preeclamptic women were significantly higher than those in the controls. Levels of MMP-3 were significantly higher in preeclamptic patients with early-onset disease; however, the MMP-3 levels in patients with late-onset preeclampsia were similar to those observed in the control subjects. MMP-9 levels were lower whereas the levels of MMP-13 were higher in both preeclamptic groups of pregnant women than in the healthy controls, but these differences were statistically insignificant. Conclusions One important finding of the present study was that MMP-3 appears to be involved solely in early-onset preeclampsia, but not in late-onset preeclampsia. Higher levels of MMP-2 and MMP-13 and lower levels of MMP-9 seem to be related to both early- and late-onset severe preeclampsia.

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“…MMP-9 is the only effective hydrolase secreted by trophoblast cells that can digest ECM. It has been reported to be involved in extracellular matrix (ECM) remodeling and processes of placental angiogenesis with structural spiral arteries transformation, which precedes proper trophoblastic invasion (10). TIMP-1 is a tissue inhibitory factor corresponding to MMP-9 and is normally secreted by the same kind of cells that secrete MMP-9.…”

Section: Discussionmentioning

confidence: 99%

MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy

et al. 2019

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Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue patients who were hospitalized in the Department of Obstetrics of People's Hospital of Xinjiang Uygur from December 2014 to September 2016 were collected, including 30 cases of severe preeclampsia, 30 cases of mild preeclampsia, and 30 cases of normal group. The distribution of MMP-9 and TIMP-1 in placenta was mainly in the cytoplasm of trophoblast cells, vascular endothelial cells and villous mesenchymal cells. The distribution of MMP-9 positive particles in the placenta tissue of the severe group was significantly reduced. The difference of MMP-9 in the three groups was statistically significant. Severe group was statistically significantly different from normal and mild group. With the aggravation of PIH, positive expression of MMP-9 was gradually decreased. TIMP-1 was expressed in each group, and difference was not statistically significant. Positive expression ratio of MMP-9/TIMP-1 in severe group was lower than that in normal pregnancy and mild group, and positive expression ratio of the two groups became smaller as the condition worsened. Positive expression of MMP-9 in placental tissue of patients with PIH decreased significantly with the severity of PIH. TIMP-1 in placental tissue of PIH patients did not change much in each group, and had no significant correlation with PIH.

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RETRACTED: Association of biochemical markers with the severity of pre‐eclampsia

Abstract: The levels of C-reactive protein, blood urea nitrogen, serum uric acid, and alanine transaminase, and the platelet count were linked with the presence and severity of pre-eclampsia.

Cited by 21 publications

References 16 publications

Relation of VEGF to the risk, severity and prognosis of preeclampsia

Relation of VEGF to the risk, severity and prognosis of preeclampsia

Altered Maternal Serum Matrix Metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in Severe Early- and Late-Onset Preeclampsia

MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy

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