“…In the present study on 418 patients from western Black Sea region of Turkey, however, ACE gene I/D polymorphism and ACE gene alleles were not found to be associated with liver fibrosis severity. The ACE gene DD genotype is thought to be associated with an increased risk of rheumatic heart disease in the Saudi population (Al-Harbi et al, 2015), with nitric oxide metabolite levels and systolic blood pressure in clinically healthy Mexican men (no effect in women) (Avila-Vanzzini et al, 2015), with high altitude pulmonary edema in an Indian population (Bhagi et al, 2015), with sepsis susceptibility in Chinese patients (Yang and Zhou, 2015), with periodontal disease susceptibility in a Korean population (Kang et al, 2015), and with cancer risk in Caucasians (Zhang et al, 2014). It has been suggested that ACE gene I/D polymorphism is a genetic risk factor for Alzheimer's disease in a Chinese population (Yuan et al, 2015), while there is reportedly no association between ACE I/D gene polymorphism and a number of conditions and associated risks including type 1 diabetic nephropathy (T1DN) susceptibility and the risk of patients with type 1 diabetes mellitus developing T1DN in a Caucasian population , chronic obstructive pulmonary disease (Ayada et al, 2014) and retinal vein occlusion (Kutlutürk et al, 2014) in a Turkish population, as well as type 2 diabetic nephropathy (T2DN) susceptibility and the risk of patients with type 2 diabetes mellitus developing T2DN in Caucasian populations .…”