[Retracted] DNM1: A Prognostic Biomarker Associated with Immune Infiltration in Colon Cancer—A Study Based on TCGA Database

Abstract

Aim. The aim of our work was to determine the utility of DNM1 as a biomarker for the diagnosis and prognosis of colon cancer (CC). Methods. DNM1 expression variations in CC vs. normal tissues were investigated using The Cancer Genome Atlas (TCGA) database. The association of DNM1 expression levels with the clinicopathological variables in CC prognosis was investigated using logistic regression analyses. Independent prognostic factors for CC were evaluated using univariate and multivariate Cox regression analyses. The correlation between DNM1 expression and immune cell infiltration was estimated using single-sample Gene Set Enrichment Analysis (ssGSEA). Results. DNM1 expression in CC tissues was significantly higher than that in normal tissues. High DNM1 expression was significantly correlated with M stage, N stage, perineural invasion and lymphatic invasion and predicted poor prognosis. The univariate analysis highlighted that DNM1 was an independent CC risk factor. Results of ssGSEA showed that DNM1 was linked to several cancer-related pathways, including the neuroactive ligand-receptor interaction, hypertrophic cardiomyopathy, ECM-receptor interaction, dilated cardiomyopathy, and calcium signaling pathway. Moreover, DNM1 expression was positively correlated with the level of infiltration by Neutrophils, Tregs, NK cells, and Macrophages. Conclusion. DNM1 has a significant function and has diagnostic and prognostic potential for CC.

Expression of anoikis-related genes and potential biomarkers in colon cancer

“…8A), we found that the cell adhesion molecule GA733-2 antigen (GA733) can exist in the solution and dissociated colon cancer cells as a higha nity noncovalent cis dimer [24]. DNM1 can be used as a biomarker for the diagnosis and prognosis of CC, and it has also been proved that DNM1 was related to several cancer-related pathways, such as ECM receptor interaction and dilated cardiomyopathy [25]. For the top pathway in which low-risk groups participate (Fig.…”

Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched

“…The low expression of DNM3 was significantly associated with high pathological grading of cervical cancer [ 71 ]. In contrast, DNM1 is overexpressed in H295R-PM-Ptc+ cells, as in colon cancer where high DNM1 expression was significantly correlated with perineural and lymphatic invasion and predicted poor prognosis [ 72 ]. Moreover, the overexpression of Huntingtin-interacting protein 1 ( HIP1 ) has also been observed in prostate and colon tumor cells where HIP1 expression was significantly associated with prostate cancer progression and metastasis.…”

Oncogenic role of a long-term high-fat diet-induced DNM1 in hepatocellular carcinoma

“…This is the rst study elucidating the HFD-induced hepatic DNM1 over-expression might affect tumor development and immune microenvironment in human HCC. So far, the link between DNM1 and human cancer has only been observed at the mRNA level in the colon [10] and bladder [19] . None of the studies has indicated a possible role of DNM1 in the cancer promoting effects of high-fat diet.…”

“…Mutations in the PH Domain of DNM1 are associated with a nonepileptic phenotype characterized by developmental delay and neurobehavioral abnormalities [8] . DNM1 has been implicated to be involved in the development of various tumors including, bladder cancer (BC) [9] , colon cancer [10] , non-small-cell lung cancer (NSCLC) [11] , and hepatocellular carcinoma (HCC) [12] ; yet, the underlying mechanisms by which DNM1 modulate tumorigenesis is unclear.…”