RETRACTED: Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells via Epigenetically Upregulating NLRP1

Liu, Yong; Wu, Hao; Jing, Jiangpeng; Li, Huanfa; Dong, Shan; Meng, Qiang

doi:10.3389/fonc.2021.622727

Cited by 14 publications

(11 citation statements)

References 43 publications

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“…Some vitro experiments on lung cancer showed pyroptosis was induced by the use of chemotherapy drugs such as dasatinib (12), paclitaxel and cisplatin (13,14). A few relevant studies illustrated glioma and pyroptosis, which is mainly focus on the miRNA, circRNA and small molecule effect (15)(16)(17)(18)(19). Pyroptosis unfold the potential effects of becoming a novel therapeutic approach of cancer, and pyroptosis-related genes GSDMD can be a prognosis factor of NSCLC.…”

Section: Introductionmentioning

confidence: 99%

Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients

Tanzhu

et al. 2022

Front. Oncol.

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The relationship between pyroptosis-related long non-coding RNAs (pyroptosis-related lncRNAs) and glioma prognosis have not been studied clearly. Basing on The Cancer Genome Atlas and The Chinese Glioma Genome Atlas datasets, we firstly identified 23 pyroptosis-related lncRNAs with Pearson coefficient |r| > 0.5 and p < 0.001. The survival probability was lower in cluster 1. 13 lncRNAs was included into signature and divided all the glioma patients into two groups, among which survival probability of the high-risk group was lower than that in low-risk group (P<0.001). The risk score was higher in the age>60, dead grade 3, cluster 1 and immune score high groups. Furthermore, subgroup analysis showed patients with different grades, IDH and 1p19ql state distinguished by the median of risk score had different survival probability. Risk score was one of independent factors for glioma prognosis, and 1-, 3-, 5-years survival were calculated in nomogram. Meanwhile, the same as the median risk score in TCGA cohort, the glioma patients from CGGA were categorized into two groups and validated the outcome mentioned above(P<0.01). GO and KEGG analysis revealed the immunity process of the targeted genes. Thus, the immune filtration we compared showed naive B cell, resting dendritic cells, activated NK cells, activated Mast cells, monocytes are higher in low-risk group. Moreover, level of the activated NK cells, M0-and M1 Macrophages was in positive relationship with the risk score. Besides, competing endogenous RNA (ceRNA) network display interaction among microRNA, lncRNAs and their targeted genes. Pyroptosis-related lncRNAs could be a dependent prognosis factor and maybe linked to the immune response in glioma. This prognosis signature had potential value in estimate the survival of the patients with glioma.

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Section: Introductionmentioning

confidence: 99%

Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients

Tanzhu

et al. 2022

Front. Oncol.

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“…In recent years, with the rapid development of bioinformatic analysis and RNA sequencing technologies, the crucial regulatory role of circRNAs has been explored in a series of tumors. [22][23][24] Chen et al found that circCAMSAP1 expression markedly increased within human OSA cells and tissue, which was closely related to OSA progression. 25 More recently, Qiu et al 26 established a circRNA-miRNA-mRNA network in OSA, in which four mRNAs were suggested as the overall survival-related mRNAs according to survival analysis.…”

Section: Discussionmentioning

confidence: 99%

Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma

Gu¹,

Duan²,

Liu³

et al. 2021

CMAR

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Introduction Osteosarcoma (OSA) is characterized by its relatively high morbidity in children and adolescents. Patients usually have advanced disease at the time of diagnosis, resulting in poor outcomes. This study focused on building a circular RNA-based ceRNA network to develop a reliable model for OSA risk prediction. Methods We used the Gene Expression Omnibus (GEO) datasets to explore the expression patterns of circRNA, miRNA, and mRNA in OSA. The prognostic value of circRNA host genes was assessed with data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database using Kaplan–Meier survival analysis. We established a circRNA-related ceRNA network and annotated its biological functions. Next, we developed a prognostic risk signature based on mRNAs extracted from the ceRNA network. We also developed a prognostic model and constructed a nomogram to enhance the prediction of OSA prognosis. Results We identified 166 DEcircRNAs, 233 DEmiRNAs, and 1317 DEmRNAs and used them to create a circRNA-related ceRNA network. We then established a prognostic risk model consisting of four genes (MLLT11, TNFRSF11B, SLC7A7, and PARVA). Moreover, we found that inhibition of MLLT11 and SLC7A7 blocked OSA cell proliferation and migration in in vitro experiments. Conclusion Our study identifies crucial prognostic genes and provides a circRNA-related ceRNA network for OSA, which will contribute to the elucidation of the molecular mechanisms underlying the oncogenesis and development of OSA.

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“…Engagingly, the reduction of hsa_circ_0001836 promoted pyroptosis of glioma cells. In mechanism, hsa_circ_0001836 knockdown may increase the expression of NLRP1 through DNA demethylation, thereby triggering cell pyroptosis ( Liu et al, 2021c ). The findings indicated that hsa_circ_0001836 might be a potential therapeutic target for the treatment of glioma.…”

Section: Non-coding Rna and Pyroptosismentioning

confidence: 99%

Regulation of Pyroptosis by ncRNA: A Novel Research Direction

Gao

Jiang

Han

et al. 2022

Front. Cell Dev. Biol.

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Pyroptosis is a novel form of programmed cell death (PCD), which is characterized by DNA fragmentation, chromatin condensation, cell swelling and leakage of cell contents. The process of pyroptosis is performed by certain inflammasome and executor gasdermin family member. Previous researches have manifested that pyroptosis is closely related to human diseases (such as inflammatory diseases) and malignant tumors, while the regulation mechanism of pyroptosis is not yet clear. Non-coding RNA (ncRNA) such as microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA) have been widely identified in the genome of eukaryotes and played a paramount role in the development of cell function and fate after transcription. Accumulating evidences support the importance of ncRNA biology in the hallmarks of pyroptosis. However, the associations between ncRNA and pyroptosis are rarely reviewed. In this review, we are trying to summarize the regulation and function of ncRNA in cell pyroptosis, which provides a new research direction and ideas for the study of pyroptosis in different diseases.

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RETRACTED: Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells via Epigenetically Upregulating NLRP1

Cited by 14 publications

References 43 publications

Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients

Molecular Subtypes and Prognostic Signature of Pyroptosis-Related lncRNAs in Glioma Patients

Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma

Regulation of Pyroptosis by ncRNA: A Novel Research Direction

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