RETRACTED: Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway

Wang, Ning; Zhou, Fang; Guo, Jinhui; Zhu, Huaiyuan; Luo, Shanshui; Cao, Jingjing

doi:10.1016/j.lfs.2018.08.052

Cited by 18 publications

(10 citation statements)

References 37 publications

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“…Figure 2A appears to contain the same images that have been published elsewhere with different labels: Figure 6K (Yin et al 2020) and Figure 3E ((Liu 2018), retracted). Figure 2E images labelled as A549 cells appears to be similar to that published elsewhere with different labels: Figure 4K (Yin et al 2020) and Figure 2E (Wang et al 2018). Figure 3G -overlap in images used in this and another unrelated article by other authors (Wang et al 2019) Figure 6A appears to contain images that have been published elsewhere with different labels: Figure 8B in ((Liu 2018), retracted), Figure 6A (Sun et al 2020), Figure 7A in (Niu et al 2019), and Figure 6A ((Gao 2017), retracted).…”

supporting

confidence: 83%

Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway

Zhang

Wang

et al. 2020

Naunyn-Schmiedeberg's Arch Pharmacol

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supporting

confidence: 83%

Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway

Zhang

Wang

et al. 2020

Naunyn-Schmiedeberg's Arch Pharmacol

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“…In addition, the involvement of CIP2A in regulating metastatic process has also been evidenced. For instance, a couple of natural compounds, Polyphyllin I and Euxanthone have been found to exhibit anti‐metastatic activity by suppressing CIP2A/PP2A signaling in prostate and colon cancer, respectively (Wang et al, ; Liu et al, ). Therefore, by suppressing CIP2A, AF might also be able to enhance the chemosensitivity and inhibit metastasis in NSCLC, although more validation experiments need to be done.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Amentoflavone Promotes Apoptosis in Non‐Small‐Cell Lung Cancer by Modulating Cancerous Inhibitor of PP2A

Shen

Chen

et al. 2019

The Anatomical Record

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Non‐small‐cell lung cancer (NSCLC) is one of the most common human malignancies. Amentoflavone (AF) is one of bioflavonoid compounds isolated from Selaginella tamariscina Spring. This study was designed to examine the effect of AF on NSCLC. Our results indicated that AF decreased cell viability of both H1299 and H358 cells. Colony formation assay also showed that AF was able to suppress the anchorage‐independent growth of NSCLC cells. AF also triggered cell cycle arrest by downregulating cyclin D1, CDK4, and CDK6. The pro‐apoptotic activity of AF was confirmed by Hoechst staining and flow cytometry. The effect of AF on activation of caspase‐3, upregulation of Bax, and downregulation of Bcl‐2 was examined by western blot. The anti‐growth and pro‐apoptotic activities of AF were further validated in xenograft murine model. iTRAQ assay showed that cancerous inhibitor of PP2A (CIP2A) expression was markedly downregulated by AF treatment in H1299 cells. In addition, qRT‐PCR and western blot also showed that AF was able to dose‐dependently inhibit CIP2A expression. Meanwhile, the activity of protein phosphatase 2A (PP2A) was enhanced by AF treatment. The mRNA and protein expression of CIP2A as well as PP2A activity in xenograft tumor tissue were examined, which indicated that the in vivo anticancer activity of AF was associated with downregulation of CIP2A and reactivation of PP2A. Moreover, our results showed that the anti‐growth and pro‐apoptotic activities of AF were augmented by CIP2A knockdown and attenuated by ectopic CIP2A expression. Our results indicated that AF exhibited anticancer activity in NSCLC by targeting CIP2A. Anat Rec, 302:2201–2210, 2019. © 2019 American Association for Anatomy

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“…It was used as a traditional Chinese medicine to treat coughs in ancient China (119). Recent studies have shown that it has antitumor effects (120,121). Chen et al collected samples from hospital patients and found that the expression of caspase-1, IL-1b and IL-18 were low in both HCC tissues and HCC cell lines.…”

Section: Hepatocellular Carcinoma and Pyroptosismentioning

confidence: 99%

“…It was used as a traditional Chinese medicine to treat coughs in ancient China ( 119 ). Recent studies have shown that it has anti-tumor effects ( 120 , 121 ). Chen et al.…”

Section: Pyroptosis With Tumorsmentioning

confidence: 99%

Pyroptosis, a New Breakthrough in Cancer Treatment

Wei

et al. 2021

Front. Oncol.

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The way of cell death can be roughly divided into two categories: cell necrosis and PCD(programmed cell death). Pyroptosis is a kind of PCD, its occurrence depends on the gasdermin protein family and it will produce inflammatory response. With constant research in recent years, more and more evidences show that pyroptosis is closely related to the occurrence and development of tumors. The treatment of tumors is a big problem worldwide. We focus on whether we can discover new potential tumor markers and new therapeutic targets from the mechanism. If we can understand the mechanism of pyroptosis and clear the relationship between pyroptosis and the development of tumors, this may provide a new reference for clinical cancer treatment.

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RETRACTED: Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway

Cited by 18 publications

References 37 publications

Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway

Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway

Retracted: Amentoflavone Promotes Apoptosis in Non‐Small‐Cell Lung Cancer by Modulating Cancerous Inhibitor of PP2A

Pyroptosis, a New Breakthrough in Cancer Treatment

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