Nursing serves as the foundation of patient-centered healthcare services, and the empathetic connections formed between nurses and patients are integral to delivering quality care. In this context, the mental well-being and empathy levels of nurses significantly impact the efficiency of healthcare services and patient contentment. This study investigates the impact of mindfulness-based empathy training and obese simulation suits on nursing students' attitudes and empathy levels towards obese patients. The research, conducted as a randomized controlled trial, encompassed 84 nursing students and employed the "Attitude Scale Towards Obese Patients," "Jefferson Empathy Scale for Nursing Students," and "Descriptive Information Form." Data analysis involved two-factor ANOVA for mixed measurements. The study revealed significant interaction effects between group and time concerning nursing students' attitudes towards obese individuals [F(1,70) = 43.281, p < 0.05] as well as their empathy levels towards obese individuals [F(1,70) = 15.657, p < 0.05]. The experimental group exhibited a noteworthy increase in both attitudes and empathy levels compared to the control group. Furthermore, Single Factor ANOVA for Repeated Measures revealed a statistically significant difference in the experimental group's attitudes and empathy scores across pretest, posttest, and follow-up assessments [p < 0.01, partial η2 = 0.492 and 0.186, respectively]. These findings underscore the effectiveness of these interventions in enhancing essential nursing competencies necessary for providing comprehensive patient care. Thus, integrating these methods into the curriculum is recommended to cultivate more positive attitudes and heightened empathy among nursing students, particularly concerning obese patients, throughout their educational journey.