RETRACTED: High-concentration supplemental perioperative oxygen and surgical site infection following elective colorectal surgery for rectal cancer: a prospective, randomized, double-blind, controlled, single-site trial

Schietroma, Mario; Cecilia, Emanuela Marina; Sista, Federico; Carlei, Francesco; Pessia, Beatrice; Amicucci, Gianfranco

doi:10.1016/j.amjsurg.2014.04.002

Cited by 39 publications

(41 citation statements)

References 44 publications

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“…Schietroma et al investigated the effect of 80% inspired oxygen compared to 30% inspired oxygen perioperatively on the incidence of SSI in 81 patients undergoing elective colorectal surgery for rectal cancer . The 80% oxygen group showed a significant lower incidence of SSI …”

Section: Resultsmentioning

confidence: 84%

“…Of these surgical procedures, five of the seven studies investigating inspired oxygen in gastrointestinal surgery had significant positive outcomes on SSI. 66,68,73,78,80 Despite these positive outcomes, the previous meta-analysis of Patel et al showed no evidence in reducing SSIs by the use of high inspired perioperative in abdominal surgery. 86 Also, in the meta-analysis of Klingel et al, no evidence is found that administration of high inspired oxygen would reduce the risk of SSIs in women undergoing cesarean section.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

“…Sixteen studies regarding perioperative inspired oxygen therapy were included. 15,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] All, except for two, 69,79 were randomized controlled trials and investigated the influence of high-concentration supplemental inspired oxygen on the incidence of SSIs in a variety of surgical procedures. Of these surgical procedures, five of the seven studies investigating inspired oxygen in gastrointestinal surgery had significant positive outcomes on SSI.…”

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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Oxygen is an important factor for wound healing. Although several different therapies investigated the use of oxygen to aid wound healing, the results of these studies are not unequivocal. This systematic review summarizes the clinical and experimental studies regarding different oxygen therapies for promoting wound healing, and evaluates the outcomes according the methodological details. A systematic literature search was conducted using Embase, Medline, Web of Science, Cochrane, PubMed publisher, and Google Scholar libraries. Clinical and experimental studies investigating oxygen for wound healing were selected. Included articles were categorized according to the kind of therapy, study design, and wound type. The methodological details were extracted and analyzed. Sixty-five articles were identified and divided in three different oxygen therapies: Local oxygen therapy, hyperbaric oxygen therapy, and supplemental inspired oxygen therapy. More than half of the included local oxygen and hyperbaric oxygen studies had one or more significant positive outcomes, 77 and 63%, respectively. Supplemental inspired oxygen therapy during gastrointestinal and vascular surgery was more likely to have a positive result than during other surgical interventions reducing surgical site infections. These many positive outcomes promote the use of oxygen treatment in the stimulation of wound healing. However, the lack of clinical studies and vast methodological diversity made it impossible to perform a proper comparison within and between the different therapies. Further randomized clinical studies are warranted to examine the value of these therapies, especially studies that investigate the more patient-friendly oxygen dressings and topical wound oxygen therapies. Also, to achieve more solid and consistent data, studies should use more standardized methods and subjects.

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Section: Resultsmentioning

confidence: 84%

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

Section: Supplemental Inspired Oxygenmentioning

confidence: 99%

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Oxygen therapies and their effects on wound healing

Smet

Kroese

Menon

et al. 2017

Wound Repair Regeneration

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“…39 However, recent studies have questioned a net beneficial effect of hyperoxia that seems associated with increased mortality and morbidity. 39 However, recent studies have questioned a net beneficial effect of hyperoxia that seems associated with increased mortality and morbidity.…”

Section: Clinical Relevancementioning

confidence: 99%

Cyclic and constant hyperoxia cause inflammation, apoptosis and cell death in human umbilical vein endothelial cells

Hafner

Schramel

et al. 2015

Acta Anaesthesiol Scand

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“…The association of obesity and infectious complications has been consistently shown in the literature [2,3,[13][14][15]17]. Options to reduce this increase in morbidity after general surgery and particularly rectal cancer resections include a laparoscopic approach or high inspired oxygen concentrations perioperatively [18,19]. The fact that the least severe complications increased morbidity rates in obese patients is logic but these did not cause increased in-hospital mortality.…”

Section: Impact Of Obesitymentioning

confidence: 99%

Impact of Body Mass Index on Early Postoperative and Long-Term Outcome after Rectal Cancer Surgery

et al. 2017

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Background: The aim of this study was to investigate the impact of obesity and underweight onto early postoperative and long-term oncological outcome after surgery for rectal cancer. Methods: Data from 2008 until 2011 was gathered by a German prospective multicenter observational study. 62 items were reported by the physicians in charge, and a consecutive follow-up was performed if the patient had signed a consent form. Patients were subclassified into: underweight, normal weight, overweight, and obese - using the definitions of the World Health Organization. Results: In total, 9,920 patients were included, of whom 2.1% were underweight and 19.4% obese. The mean age was 68 years (range 21-99 years). Postoperative morbidity (mean 38.0%) was significantly increased in underweight and obese patients (p < 0.001). In-hospital mortality was 3.1% on average with no significant differences among patient groups (p = 0.176). The 5-year overall survival ranged between 36.9 and 61.3% and was worse in underweight and prolonged in overweight and obese patients compared to those with normal weight (p < 0.001 each). While the 5-year disease-free survival was increased in overweight and obese patients (p < 0.05 each), the 5-year local recurrence rate showed no correlation (p > 0.05 each). Multivariate analysis revealed that advanced age, higher ASA scoring, postoperative morbidity, and advanced tumor growth worsened the long-term survival independently. Conclusions: Underweight patients had a worse early and long-term outcome after rectal cancer surgery. Overweight and obesity were associated with a significantly better long-term survival.

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RETRACTED: High-concentration supplemental perioperative oxygen and surgical site infection following elective colorectal surgery for rectal cancer: a prospective, randomized, double-blind, controlled, single-site trial

Cited by 39 publications

References 44 publications

Oxygen therapies and their effects on wound healing

Oxygen therapies and their effects on wound healing

Cyclic and constant hyperoxia cause inflammation, apoptosis and cell death in human umbilical vein endothelial cells

Impact of Body Mass Index on Early Postoperative and Long-Term Outcome after Rectal Cancer Surgery

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