[Retracted] hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR‐18a‐5p/miR‐18b‐5p/E2F5 Axis

Abstract

Background. Retinoblastoma (RB) is the commonest primary intraocular malignancy during childhood. Circular RNAs (circRNAs) act as regulators in RB development, and hsa_circ_E2F5 (circ_0084811 in this study) was found to be highly expressed in RB cells, so we wanted to identify its detailed molecular mechanism. Methods. The expression level of circ_0084811 in RB cells was tested by RT-qPCR and its effects on RB cells were evaluated through functional assays. The regulatory mechanism that circ_0084811 may exert in RB progression was testified through mechanism experiments. Results. High circ_0084811 expression in RB cells facilitated cell proliferation but inhibited cell apoptosis. The enrichment of acetylation of histone 3 lysine 27 (H3K27ac) in circ_0084811 promoter induced circ_0084811 upregulation. Moreover, circ_0084811 regulated E2F transcription factor 5 (E2F5) expression via sponging microRNA-18a-5p (miR-18a-5p) and microRNA-18b-5p (miR-18b-5p). Conclusion. circ_0084811 modulated RB progression via the miR-18a-5p/miR-18b-5p/E2F5 axis.

An Update on Circular RNA in Pediatric Cancers

“…Furthermore, circ_ 0084811 deficiency induced cell apoptosis, and this effect could be partially countervailed by the knockdown of miR-18a-5p or miR-18b-5p while it could be greatly counteracted by E2F5 upregulation. These observations suggested that circ_0084811 regulates E2F5 expression via sponging miR-18a-5p and miR-18b-5p [84].…”

Retracted: hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”