RETRACTED: Peptide-induced formation of protein aggregates and amyloid fibrils in human and guinea pig αA-crystallins under physiological conditions of temperature and pH

Anbarasu, Kumarasamy; Jeyarajan, Sivakumar; Cheon, Jonathan; Premceski, Anthony; Seidel, Eric; Kimler, Victoria A.; Giblin, Frank J.

doi:10.1016/j.exer.2018.11.016

Cited by 5 publications

(5 citation statements)

References 81 publications

(112 reference statements)

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“…74 75 The accumulation of polypeptides as a result of the proteolytic modification of lens proteins can also have beneficial and detrimental effects. 76 It is important to appreciate this concept when considering pharmaceutical/small molecule interventions to either arrest or even reverse cataract.…”

Section: Cytoskeletal Proteinsmentioning

confidence: 99%

Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches

et al. 2020

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Cataract is the most common cause of blindness in the world; during infancy and early childhood, it frequently results in visual impairment. Congenital cataracts are phenotypically and genotypically heterogeneous and can occur in isolation or in association with other systemic disorders. Significant progress has been made in identifying the molecular genetic basis of cataract; 115 genes to date have been found to be associated with syndromic and non-syndromic cataract and 38 disease-causing genes have been identified to date to be associated with isolated cataract. In this review, we briefly discuss lens development and cataractogenesis, detail the variable cataract phenotypes and molecular mechanisms, including genotype-phenotype correlations, and explore future novel therapeutic avenues including cellular therapies and pharmacological treatments.

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Section: Cytoskeletal Proteinsmentioning

confidence: 99%

Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches

et al. 2020

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“…Исходя из вышеизложенного, можно отметить, что представленные теории патогенеза возрастной катаракты связаны между собой и базируются на возрастных изменениях метаболизма белков (большинство ядерных α-кристаллинов нерастворимы), глюкозы (неферментативное гликозилирование белков), липидного обмена, активности ферментов и потери мембранного потенциала клеток (увеличение содержания в клетке Na + и Ca 2 + и уменьшение уровня К + ). Образование высокомолекулярных белковых комплексов, ковалентно связанных дисульфидными связями -ключевое звено всех теорий патогенеза катаракты [7,20]. Наличие таких белковых агрегантов обусловливает то, что свет в этих участках рассеивается и прозрачность хрусталика снижается.…”

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Current Concepts of Molecular Mechanisms of Age-Related Changes in Eye Lens

Kiseleva,

Zaitsev

2023

Oftalʹmologiâ

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Age-related cataract is the leading cause of vision loss in old people worldwide. According to the World Health Organization it accounts for 47.8 % of the total number of ocular pathologies in people over 50 years old. Despite the rapid development of cataract surgery technology, surgery remains a challenge due to its cost and the increasing number of patients. Literature review is devoted to current concepts of pathogenesis and molecular mechanisms of age-related changes in eye lens. There are the three main theories of cataractogenesis: oxidative stress; the impact of quinoid substances, which are formed due to the impairment of aromatic amino acid metabolism and the activation of aldo reductase enzyme with subsequent accumulation of sorbitol, reactive oxygen species (ROS) generation, dysfunction of Na+/K+ channels and calcium deregulation causing lens epithelial cells apoptosis. Theories of pathogenesis are linked and based on the development of age-related changes in protein metabolism (the majority of nuclear α-crystallins are insoluble), glucose metabolism (non-enzymatic glycosylation of proteins), lipid metabolism, enzyme activity and the loss of membrane potential of cells ( the increase of Na+ and Ca2+ level and the decrease of K+ level). Key element of all theories of age-related changes in eye lens is the aggregation of high molecular weight proteins covalent-bonded of disulfide linkages. Based on molecular mechanisms of cataractogenesis, the development of pathogenetically oriented medical methods of correction of the age-related changes in lens is carried on. This review provides information on results of experimental and clinical studies which demonstrate the anti-cataract effect of Pirenoxine 0, 005 %.

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“…Одной из ведущих теорий патогенеза катаракты является теория оксидативного стресса, описывающая дисбаланс между окисляющими реакциями и антиоксидативной защитой, при котором ингибируется работа Na + /K + -насоса и гидролиза АТФ, повышается уровень H 2 O 2 , что обусловливает гибель эпителиальных клеток и образование белковых комплексов, ковалентно связанных дисульфидными связями, что приводит к развитию помутнений хрусталика [4][5][6].…”

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Modern Ultrasound Methods of Studying the Biomechanical Properties of the Lens. Review

Sakalova¹,

Андреева²,

Al-Mahdar³

2021

Oftalʹmologiâ

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Cataract is one of the most common diseases in ophthalmology nowadays, ranks first in the world among the causes of reversible blindness and remains a multifactorial disease, involving complex interactions between metabolic disorders, genetic predisposition and environmental risk factors. Studying the properties of the lens is important in “cataract” surgery from a clinical perspective. Determination of the mechanical hardness of the lens is particularly important to optimize the amount of ultrasonic energy expended during phacoemulsification in order to minimize the number of complications, however, the existing methods are rather subjective and based mainly on biomicroscopy with visual assessment. Ultrasound constitutes a significant part of the methods of studying the lens. There are methods for determining the density of the lens using A-scan (one-dimensional image) and B-scan (two-dimensional image). Basically, these techniques provide information on acoustic density, but not on mechanical hardness. Several studies have used a high frequency needle tranducer to determine the hardness of the lens. The authors believe that the combination of an ultrasound needle tranducer and a phacoemulcification probe for real-time feedback may provide better surgical efficiency. Ultrasound elastography, static and dynamic is used to assess the elastic properties of tissues in many areas of medicine. In ophthalmology, elastography is not used in general clinical practice, however, the density of the lens is assessed in vivo using compression elastography in some studies. Also, a number of researchers offer combined system of ultrasound elastography and OCT, called OCTelastography. It is assumed that OCT elastography can provide better spatial image resolution and faster acquisition rates. The literature review reveals summarized data on methods of studying the lens, its acoustic and mechanical density, using various ultrasound research techniques, including such poorly understood methods in ophthalmology as compression elastography and optical coherent elastography.

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RETRACTED: Peptide-induced formation of protein aggregates and amyloid fibrils in human and guinea pig αA-crystallins under physiological conditions of temperature and pH

Cited by 5 publications

References 81 publications

Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches

Inherited cataracts: molecular genetics, clinical features, disease mechanisms and novel therapeutic approaches

Current Concepts of Molecular Mechanisms of Age-Related Changes in Eye Lens

Modern Ultrasound Methods of Studying the Biomechanical Properties of the Lens. Review

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