Retracted: Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder

Abstract

This study is the first double-blinded RCT proving the efficacy of vitamin D3 in ASD patients. Depending on the parameters measured in the study, oral vitamin D supplementation may safely improve signs and symptoms of ASD and could be recommended for children with ASD. At this stage, this study is a single RCT with a small number of patients, and a great deal of additional wide-scale studies are needed to critically validate the efficacy of vitamin D in ASD.

Lack of effect of vitamin D3supplementation in autism: a 20-week, placebo-controlled RCT

“…Low-level evidence based on a single case report25 and two open-label studies support the role of vitamin D supplementation in ASD 26 27. Additionally, a single, double-blind, randomised, placebo-controlled trial reported benefit of supplementation in ASD 28. However, any potential mechanisms mediating a positive effect of vitamin D supplementation in ASD remain obscure.…”

Hypocalcemic Seizure Due to Severe Vitamin-D Deficiency in an Adolescent with Obesity and Autism

“…The etiology of ASD is not known but multifactorial, based on the interplay of genetic predisposition and environmental influences. Among the environmental influences, recent studies report that Vitamin D deficiency is common in children with autism and its correction improves their behavior [2].…”

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

“…A case report [147], along with open and controlled trials [142,148], observed an ASD symptom scores reduction after vitamin D 3 supplementation. However, recent placebo-controlled clinical trials have found divergent results following vitamin D 3 supplementation for ASD [149,150].…”