[Retracted] The Promotional Effect of Hollow MnO2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis

Abstract

Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO2 could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H-MnO2-PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug-delivery vector H-MnO2-PEG by chemical synthesis and found that H-MnO2-PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H-MnO2-PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H-MnO2-PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H-MnO2-PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer.

The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer

“…Besides, the combination of H-MnO 2 —PEG/BJOE (Brucea javanica oil emulsion) shows the killing effect of BJOE on cancer cells and tumor inhibition. BJOE can also promote apoptosis in endometrial cancer by regulating protein expression [ 128 ].…”

Manganese-Based Nanotheranostics for Magnetic Resonance Imaging-Mediated Precise Cancer Management

“…Furthermore, pH-sensitive MnO 2 @bovine serum albumin (BSA) NPs showed MR contrast signal amplification stimulated by the acidic extracellular environment of solid tumors. 71 Hu et al 72 chemically synthesized a drug delivery vector, PEG coated hollow MnO 2 , which significantly inhibited the proliferation of endometrial cancer. In other cases of clinical synergy, Hou et al 73 synthesized a biocompatible MnO 2 -containing agarose hydrogel using the sol-gel method for an enhanced PTT/PDT combination.…”

Retracted: The Promotional Effect of Hollow MnO2 with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”