Retraction Note: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Sakat, S; Mani, Kamaraj; Demidchenko, Yulia O.; Gorbunov, Evgeniy A.; Тарасов, С. А.; Mathur, Archana; Epstein, Oleg

doi:10.1007/s10753-020-01359-x

Cited by 5 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both acute and chronic models of infammation were employed to evaluate the in vivo anti-infammatory properties of A. mexicana. Since the relative potency estimates obtained from the majority of medications tend to mirror clinical experience, the carrageenan-induced hind paw edema model has been utilized extensively for the discovery and evaluation of anti-infammatory agents [94]. Overproduction of the infammatory prostaglandins is the major mechanism responsible for carrageenan-induced paw edema formation [95].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Introduction. The solvent fractions of the fruits of Argemone mexicana L. (Papaveraceae) have not yet been explored scientifically for in vivo wound healing and anti-inflammatory activities. The objective of this study was, therefore, to evaluate in vivo wound healing and anti-inflammatory activities of the solvent fractions of the fruit of Argemone mexicana L. (Papaveraceae) in rats. Method. The crude extract of Argemone mexicana was fractionated with n-hexane, ethyl acetate, and distilled water. Wound healing activity was evaluated using excision and incision wound models while anti-inflammatory activity was evaluated using carrageenan-induced rat paw and cotton pellet-induced granuloma models. The fractions were evaluated at 5 and 10% ointments using moist-exposed burn ointment as the standard drug, and 100, 200, and 400 mg/kg test doses using aspirin, and dexamethasone as standard drugs for wound healing and anti-inflammatory activities, respectively. All treatment administrations were made orally for anti-inflammatory activity and applied topically for wound healing activity. Result. The 10% w/w ethyl acetate fraction ointment showed a significant percentage of wound contraction, reduced period of epithelialization, increased amount of fibrosis, neovascularization, and collagen tissue formation ( p < 0.01 ). The ethyl acetate fraction also showed a significant increase in tensile strength (55%; p < 0.01 ) and (81.10%; p < 0.01 ) at the tested doses of 5 and 10% w/w ointments, which was comparable to moist-exposed burn ointment. The ethyl acetate fraction also revealed a significant percent edema inhibition (61.41%; p < 0.01 ), suppression of the exudate (38.09% p < 0.01 ), and granuloma mass formations (53.47% p < 0.01 ) at the tested dose of 400 mg/kg. Conclusion. The results of this study showed that the Ethyl acetate fraction of Argemone mexicana fruit has significant wound healing and anti-inflammatory activities which support the traditional claims of the experimental plant.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Ayele

Abebe

Muche

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The anti-inflammatory activity of TP extract was evaluated by modified methods of the α-carrageenan-induced rat paw edema model [21]. Acute inflammation was induced by subplantar injection of 100 μL of 1% α-carrageenan (1% suspension in saline) into the right hind paw of the rat.…”

Section: Evaluation Of Anti-inflammatory Activitymentioning

confidence: 99%

Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

2023

View full text Add to dashboard Cite

Teucrium polium (germander, Lamiaceae) is a local plant in Qatar that has been used in folk medicine to treat numerous illnesses. It is known for its antioxidant, analgesic, anticancer, and antibacterial activities. This study aimed to evaluate the anti-inflammatory activity of Teucrium polium (TP) extract by α-carrageen-induced paw edema in adult Sprague Dawley rats. The animals were randomly grouped into control, acute inflammation, and plant extract groups. Acute inflammation was induced by a sub-plantar injection of 100 µL of 1% α-carrageenan into the rat’s right hind paw. Three different doses of the ethanolic extract of TP were tested at different time periods (1, 3, and 5 hours). All doses of the TP ethanolic extract showed significant inhibition of α-carrageenan-induced rat paw edema in a dose-dependent manner in both early and late phases of edema formation. The size of the α-carrageen induced paw edema was significantly reduced one, three, and five hours after TP extract injection compared to the acute inflammation group. This inhibition was accompanied by high expression of interleukin 10 (IL-10) and low expression of monocyte chemoattractant protein 1 (MCP-1), IL-1β and tumor necrosis factor alpha (TNF-α). The results indicated that the ethanolic extracts of TP possess significant anti-inflammatory and potential pharmaceutical properties.

show abstract

“…It is produced by means of a special process, which results in the high efficacy of diclofenac in the released active form, with almost no side effects. 57 Because the pharmaceutical effects of diclofenac primarily occur due to the hydrogen-bond interaction between its carboxyl group and the targets (Tyr-385 and Ser-530 of the COX enzymes), it is important to look into the involvement of this carboxyl group in other processes, such as the formation of the hydration shell of diclofenac. Therefore, understanding the physicochemical properties and features of the hydration shell formation is essential for developing a form of diclofenac that could sterically facilitate a higher pharmaceutical efficacy (and safety).…”

Section: Introductionmentioning

confidence: 99%

Hydration of the Carboxylate Group in Anti-Inflammatory Drugs: ATR-IR and Computational Studies of Aqueous Solution of Sodium Diclofenac

Levina

Penkov

Rodionova³

et al. 2018

ACS Omega

Self Cite

View full text Add to dashboard Cite

Diclofenac (active ingredient of Voltaren) has a significant, multifaceted role in medicine, pharmacy, and biochemistry. Its physical properties and impact on biomolecular structures still attract essential scientific interest. However, its interaction with water has not been described yet at the molecular level. In the present study, we shed light on the interaction between the steric hindrance (the intramolecular N–H···O bond, etc.) carboxylate group (−CO2–) with water. Aqueous solution of sodium declofenac is investigated using attenuated total reflection-infrared (ATR-IR) and computational approaches, i.e., classical molecular dynamics (MD) simulations and density functional theory (DFT). Our coupled classical MD simulations, DFT calculations, and ATR-IR spectroscopy results indicated that the −CO2– group of the diclofenac anion undergoes strong specific interactions with the water molecules. The combined experimental and theoretical techniques provide significant insights into the spectroscopic manifestation of these interactions and the structure of the hydration shell of the −CO2– group. Moreover, the developed methodology for the theoretical analysis of the ATR-IR spectrum could serve as a template for the future IR/Raman studies of the strong interaction between the steric hindrance −CO2– group of bioactive molecules with the water molecules in dilute aqueous solutions.

show abstract

Retraction Note: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Cited by 5 publications

References 1 publication

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Evaluation of In Vivo Wound-Healing and Anti-Inflammatory Activities of Solvent Fractions of Fruits of Argemone mexicana L. (Papaveraceae)

Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study

Hydration of the Carboxylate Group in Anti-Inflammatory Drugs: ATR-IR and Computational Studies of Aqueous Solution of Sodium Diclofenac

Contact Info

Product

Resources

About