Retraction Note: Superiority of [68Ga]Ga-FAPI-04/[18F]FAPI-42 PET/CT to [18F]FDG PET/CT in delineating the primary tumor and peritoneal metastasis in initial gastric cancer

Fu, Lilan; Huang, Shun; Wu, Hubing; Ye, Dong; Xie, Fei; Wu, Ruihe; Zhou, Kemin; Tang, Ganghua; Zhou, Wenlan

doi:10.1007/s00330-022-09386-y

Cited by 3 publications

(21 citation statements)

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“…The estimated pooling median SUV max of FAP was higher for primary tumors (pooling median, 12.83; 95% CI, 11.34-15.30) 22,23,[25][26][27][28][29][30][31]33,34,36,[38][39][40][42][43][44][45][46][47][48][49][50][51] than the other observed lesions such as lymph node (pooling median, 10.46; 95% CI, 8.14-10.98), 22,[24][25][26][27][28][29][30][31]36,38,39,[42][43][44][47][48][49][50][51] bone (pooling median, 9.23; 95% CI, 7.36-10.31), 22,24-28, 30,35,38,39,41-44,48-51 peritoneal (pooling median, 9.0; 95% CI, 6.71-9.92), 22,27,30,…”

Section: The Difference Of Suv Max For Positive Lesion Between Fap An...mentioning

confidence: 97%

“…The cancer type of included studies is diverse in that 9 studies of all studies involved various cancer, [22][23][24]26,30,35,37,39,48 5 studies involved gastric cancer or gastrointestinal system (GIS) cancer, 32,42,44,45,47 4 studies involved head and neck cancer, 29,31,38,40 3 studies involved hepatocellular carcinoma (HCC), 27,33,34 2 studies respectively involved breast cancer, 25,28 sarcoma, 43,46 and lung cancer, 49,51 and 1 study involved esophageal cancer, 36 myeloma, 41 and pancreatic cancer, 50 respectively (Table 1).…”

Section: Qualitative Analysis Basic Characteristics Of Included Studi...mentioning

confidence: 99%

“…According to cancer type analysis, the DR of the primary tumor by FAP tracer is higher than that by FDG in gastric cancer and GIS cancer (RRs, 1.10 per patient and 1.24 per lesion) 36,42,44,45,47 pancreatic cancer (RRs, 1.37 per patient and 1.36 per lesion), 50 sarcoma (RR 1.06 per patient, 1.16 per lesion), 43,46 breast cancer (RRs, 1.07 per patient and 1.27 per lesion), 28 and head and neck cancer (RR, 1.12 per patient). 29,38,40 However, the DR of the FAP tracer for lung cancer is equal to that of FDG 49,51 (Fig.…”

Section: The Better Detection Of Fap Than Fdg Tracer In Various Cancersmentioning

confidence: 99%

“…Depending on the cancer type in the included studies, the number of gastric cancer patients was the most observed, 22,30,32,37,39,42,44,45,47,48 followed by head and neck cancer 22,23,26,29,31,35,38,40,48 and lung cancer. 22,23,26,35,39,48,49,51 In various cancers, FAP uptake was higher than FDG uptake in primary tumors from gastric, 22,30,32,37,39,42,44,45,47,48 colorectal, 22,23,30,32,37,39,48 HCC/intrahepatic cholangiocarcinoma, 22,27,[33][34][35]39,…”

Section: The Difference Of Suv Max For Positive Lesion Between Fap An...mentioning

confidence: 99%

“…22,39,40,50 This may be 23,31,33 LN Metastasis (No. Studies = 5) 22,23,40,42,45 Primary Tumor (No. Studies = 4) LN Metastasis (No.…”

Section: The Better Detection Of Fap Than Fdg Tracer In Various Cancersmentioning

confidence: 99%

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Comparison of the Detection Performance Between FAP and FDG PET/CT in Various Cancers

et al. 2022

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Purpose: 18 F-FDG is the dominant radiotracer in oncology; however, it has limitations. Novel labeled fibroblast activation protein (FAP) radiotracers have been developed and published in several studies. Thus, this meta-analysis aimed to compare the detection rates (DRs) of FDG and FAP, based on previous studies from a systematic review. Methods: PubMed/MEDLINE and Cochrane library databases were used to perform a comprehensive and systematic search and are updated to April 30, 2022. The DR, relative risk, and the SUV max were calculated between the FAP and FDG tracers. Finally, the sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve of FAP and FDG were analyzed using gold and reference standards. Results: Thirty studies (1170 patients) were included in the meta-analysis. The relative risks of FAP DR for the primary tumor, recurrent tumor, lymph node metastasis, and distant metastasis were FDG 1.06-to 3.00-fold per patient and per lesion. For the primary tumor, FAP uptake was most intense in pancreatic cancer, followed by head and neck, cervical, colorectal, lung, gastric, and hepatocellular carcinoma, and was higher than FDG except for urological system cancer. The sensitivity (0.84-0.98), diagnostic odds ratio (19.36-358.47), and summary receiver operating characteristic curve (0.94-0.99) of FAP based on patient and lesion were better for primary tumors, LN metastasis, and distant metastasis than FDG. Conclusions: Fibroblast activation protein is an extremely potential radiotracer to replace most of the use of FDG in oncology. It is noteworthy that the FAP tracers for primary tumors had low specificity despite excellent sensitivity and had lower uptake than FDG in urological system cancer. In addition, the difference in detection between FAP and FDG for LN metastasis could not be certain in sarcoma.

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Section: The Difference Of Suv Max For Positive Lesion Between Fap An...mentioning

confidence: 97%

Section: Qualitative Analysis Basic Characteristics Of Included Studi...mentioning

confidence: 99%

Section: The Better Detection Of Fap Than Fdg Tracer In Various Cancersmentioning

confidence: 99%

Section: The Difference Of Suv Max For Positive Lesion Between Fap An...mentioning

confidence: 99%

“…22,39,40,50 This may be 23,31,33 LN Metastasis (No. Studies = 5) 22,23,40,42,45 Primary Tumor (No. Studies = 4) LN Metastasis (No.…”

Section: The Better Detection Of Fap Than Fdg Tracer In Various Cancersmentioning

confidence: 99%

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Comparison of the Detection Performance Between FAP and FDG PET/CT in Various Cancers

et al. 2022

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Current research topics in FAPI theranostics: a bibliometric analysis

Hoven

Keijsers

Lam

et al. 2022

Eur J Nucl Med Mol Imaging

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Evaluation of FAPI PET imaging in gastric cancer: a systematic review and meta-analysis

Ruan,

Zhao,

Cai

et al. 2023

Theranostics

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Purpose: Recent studies suggest that 68 Ga-FAPI PET/CT demonstrated superiority over 18 F-FDG PET/CT in the evaluation of various cancer types, especially in gastric cancer (GC). By comprehensively reviewing and analysing the differences between 68 Ga-FAPI and 18 F-FDG in GC, some evidence is provided to foster the broader clinical application of FAPI PET imaging. Methods: In this review, studies published up to July 3, 2023, that employed radionuclide labelled FAPI as a diagnostic radiotracer for PET in GC were analysed. These studies were sourced from both the PubMed and Web of Science databases. Our statistical analysis involved a bivariate meta-analysis of the diagnostic data and a meta-analysis of the quantitative metrics. These were performed using R language. Results: The meta-analysis included 14 studies, with 527 patients, of which 358 were diagnosed with GC. Overall, 68 Ga-FAPI showed higher pooled sensitivity (0.84 [95% CI 0.67-0.94] vs. 0.46 [95% CI 0.32-0.60]), specificity (0.91 [95% CI 0.76-0.98] vs. 0.88 [95% CI 0.74-0.96]) and area under the curve (AUC) (0.92 [95% CI 0.77-0.98] vs. 0.52 [95% CI 0.38-0.86]) than 18 F-FDG. The evidence showed superior pooled sensitivities of 68 Ga-FAPI PET over 18 F-FDG for primary tumours, local recurrence, lymph node metastases, distant metastases, and peritoneal metastases. Furthermore, 68 Ga-FAPI PET provided higher maximum standardized uptake value (SUVmax) and tumour-to-background ratios (TBR). For bone metastases, while 68 Ga-FAPI PET demonstrated slightly lower patient-based pooled sensitivity (0.93 vs. 1.00), it significantly outperformed 18 F-FDG in the lesion-based analysis (0.95 vs. 0.65). However, SUVmax (mean difference [MD] 1.79 [95% CI -3.87-7.45]) and TBR (MD 5.01 [95% CI -0.78-10.80]) of bone metastases showed no significant difference between 68 Ga-FAPI PET/CT and 18 F-FDG PET/CT. Conclusion: Compared with 18 F-FDG, 68 Ga-FAPI PET imaging showed improved diagnostic accuracy in the evaluation of GC. It can be effectively applied to the early diagnosis, initial staging, and detection of recurrence/metastases of GC. 68 Ga-FAPI may have the potential of replacing 18 F-FDG in GC in future applications.

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Retraction Note: Superiority of [68Ga]Ga-FAPI-04/[18F]FAPI-42 PET/CT to [18F]FDG PET/CT in delineating the primary tumor and peritoneal metastasis in initial gastric cancer

Cited by 3 publications

References 0 publications

Comparison of the Detection Performance Between FAP and FDG PET/CT in Various Cancers

Comparison of the Detection Performance Between FAP and FDG PET/CT in Various Cancers

Current research topics in FAPI theranostics: a bibliometric analysis

Evaluation of FAPI PET imaging in gastric cancer: a systematic review and meta-analysis

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