Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis

Sano, Tatsuhiko; Kobayashi, Zen; Takaoka, Ken; Ota, Katsuya; Onishi, Iichiroh; Iizuka, Mihoko; Tomimitsu, Hiroyuki; Sato, Shuzo

doi:10.1111/ncn3.12216

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Other reports have described cases of Onodi cell sinusitis complicated by abscess formation and invasive mucormycosis eventually leading to orbital apex syndrome, 7 , 12 a more catastrophic ophthalmologic condition characterized by acute vision and ophthalmoplegia. After the diagnosis was confirmed in these cases, patients were treated with surgical decompression and appropriate antimicrobial therapy and went on to experience resolution of acute infectious and visual symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis

OuYang

Long

Azam

et al. 2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 99%

“… 15 MR imaging of the orbit has also proven useful in further characterizing the involvement of surrounding neurovascular structures, as in this and several other cases. 7 , 9 , 10 , 11 , 12 …”

Section: Discussionmentioning

confidence: 99%

Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis

OuYang

Long

Azam

et al. 2022

American Journal of Ophthalmology Case Reports

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“… 38 Direct compression of the optic nerves has been reported due to a mass in the sphenoid sinus, which was contiguous with the optic nerve. 39 …”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-19-associated Rhino-orbital and cerebral mucormycosis: clinical and radiological presentations

et al. 2022

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We describe presenting clinical and imaging manifestations of SARS-CoV-19-associated rhino-oculo-cerebral mucormycosis (ROCM) in a hospital setting during the second wave of SARS-CoV-19 pandemic in India. Data on the presenting manifestations was collected from March 01 to May 31, 2021. Associations between clinical and imaging findings were explored, specifically: (1) the presence or absence of orbital pain and infiltration of superior orbital fissure on imaging; (2) the presence of unilateral facial nerve palsy and pterygopalatine fossa infiltration and geniculate ganglion signal on contrast magnetic resonance imaging and (3) vision loss and optic nerve findings on imaging. Orbital pain was reported by six of 36 subjects. A fixed, frozen eye with proptosis and congestion was documented in 26 (72%), complete vision loss in 23 (64%) and a unilateral lower motor neuron facial nerve palsy in 18 (50%). No association was found between the presence of orbital pain and superior orbital fissure infiltration on imaging. The ipsilateral geniculate ganglion was found to enhance more profoundly in seven out of 11 subjects with facial palsy and available MR imaging, and the ipsilateral pterygopalatine fossa was found infiltrated in 14. Among 23 subjects with complete loss of vision, nine (39%) demonstrated long-segment bright signal in posterior optic nerve on diffusion MR images. We conclude that orbital pain might be absent in SARS-CoV-19-associated ROCM. Facial nerve palsy is more common than previously appreciated and ishaemic lesions of the posterior portion of the optic nerve underlie complete vision loss.

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“…Reduction in visual acuity in cases with mucormycosis is explainable on the basis of infarctions in blood vessels supplying retina or optic nerve, compression on the nerve along its course within cavernous sinus, or direct infection and necrosis [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

A case series of post COVID-19 mucormycosis—a neurological prospective

Roushdy

Hamid

2021

Egypt J Neurol Psychiatry Neurosurg

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Background Direct neurological manifestations of coronavirus disease whether peripheral or central are reported worldwide. Yet, along the 3rd wave of the pandemic especially in India, an associated angioinvasive opportunistic infection with mucormycosis in COVID-19 cases is emerging. Case presentation The current case series which represents 4 patients with mucormycosis post COVID-19 is one of a few if not the first case series that discusses post COVID-19 mucormycosis from a neurological prospective in a tertiary hospital in Egypt. All cases but one presented with total ophthalmoplegia, and only one was diagnosed as a cavernous sinus thrombosis; meanwhile, orbital cellulitis and orbital apex syndrome were responsible of ophthalmoplegia in two cases. Mortality reached 25%, and the case that died suffered cutaneous as well as rhino-cerebral type with a delayed presentation to hospital. Conclusion A rare but fatal fungal infection is ought to be nowadays kept in mind in COVID-19 active cases as well as in recovered COVID-19 patients, especially those who have comorbid medical conditions as uncontrolled diabetes and who were treated with large doses of corticosteroids.

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Retrobulbar optic neuropathy associated with sphenoid sinus mucormycosis

Cited by 7 publications

References 7 publications

Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis

Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis

SARS-CoV-19-associated Rhino-orbital and cerebral mucormycosis: clinical and radiological presentations

A case series of post COVID-19 mucormycosis—a neurological prospective

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