Retrograde double-labeling study of retinal ganglion cells from the ipsilateral vLGN and SC in the albino rat

Ahmed, A.K.M. Farid; Dong, Kai; Hanna, G.F.B; Yamadori, Takashi

doi:10.1016/s0304-3940(98)00114-1

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…A series of conceptual and experimental advances have made it possible to identify the neural circuits of retinotectal neurons and the connection of RGCs in the retina to their terminations in the SC of midbrain [1, 4, 10, 13, 23, 27, 31]. In general, retinotectal RGCs as non-standard cells have direction selectivity, local edge detector and suppressed-by-contrast receptive field (W type and Y type).…”

Section: Discussionmentioning

confidence: 99%

“…Y type RGCs project to the lower portion of the stratum griseum superficial, and the upper portion of the stratum griseum intermediale [4, 17, 24, 38]. Moreover, distribution of retinotectal RGCs was also revealed in the rabbit [43], rat [1] and ground squirrel [27, 31] by using retrograde staining. Especially, the ground squirrel RGCs were indentified in 4 types of retinotectal neurons, including the beta-type ganglion cell (X type).…”

Section: Discussionmentioning

confidence: 99%

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Types of Parvalbumin-Containing Retinotectal Ganglion Cells in Mouse

Lee

et al. 2012

Acta Histochem. Cytochem

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The calcium-binding protein parvalbumin (PV) occurs in the retinal ganglion cells (RGCs) of various vertebrate species. In the present study, we aimed to identify the types of PV-containing RGCs that project to the superior colliculus (SC) in the mouse. We injected retrograde tracer dextran into the mouse SC to label RGCs. PV-containing RGCs were first identified by immunocytochemistry and then neurons double-labeled with dextran and PV were iontophoretically injected with a lipophilic dye, DiI. Subsequently, confocal microscopy was used to characterize the morphologic classification of the PV-immunoreactive (IR) retinotectal ganglion cells on the basis of dendritic field size, branching pattern, and stratification within the inner plexiform layer. Among the 8 different types of PV-containing RGCs in the mouse retina, we found all 8 types of RGCs projecting to the SC. The RGCs were heterogeneous in morphology. The combined approach of using tracer injection and a single cell injection after immunocytochemistry on a particular protein will provide valuable data to further understand the functional features of the RGCs which constitute the retinotectal pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Types of Parvalbumin-Containing Retinotectal Ganglion Cells in Mouse

Lee

et al. 2012

Acta Histochem. Cytochem

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“…On the other hand, RGCs that send bifurcating axons unilaterally to the LGN and tectum on same side (Hada and Hayashi, ) are distributed in the whole retinal area of the contralateral eye (Kondo et al., ) and in the ventrotemporal crescent of the retina of the ipsilateral eye in rat (Farid Ahmed et al., , ). Optic fibre bifurcation occurs with a higher frequency in rats (Yamadori et al., ; Farid Ahmed et al., ) but considerably lower frequency in cat (Illing, ; Kondo et al., ). In chicks, as shown in the present study, bifurcating optic fibres that project to the unilateral (contralateral) thalamus and tectum were found frequently, and the cells of origin of these fibres were mostly tha‐RGCs in the central retina.…”

Section: Discussionmentioning

confidence: 99%

Retrograde Tracing with Fluorescent Microspheres Reveals Bifurcating Projections from Central Retina to Tectum and Thalamus in Chicks

Cao

Naito

Chen

2012

Anat Histol Embryol

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The goal of this study is to demonstrate the dual-projection pattern of retinal ganglion cells (RGCs) projecting to the tectum and visual thalamus in chick using retrograde fluorescent tracers and also to define the morphological properties of these RGCs with dual projections by intracellular injection of Lucifer Yellow (LY) combined with immunohistochemistry. Thirty-two chicks received double injections of green and red fluorescent microspheres into their thalamus and tectum in the same side. In the central retina, most of the labelled RGCs were tec-RGCs (RGCs projecting to the tectum), a quarter was tha-RGCs (RGCs projecting to the thalamus), and almost all of the tha-RGCs were double-labelled RGCs. An intracellular injection of LY into the double-labelled RGCs showed all six groups of RGCs without specific populations in each group (J. Comp. Neurol., 2004, 469: 360). These dendritic patterns were mostly mono- and bistrata, which extended horizontally in the deeper part of the inner plexiform layer.

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“…For example, in the rabbit almost all RGCs project to the SC (Vaney et al, 1981). In the cat, 50% of all RGCs project to the SC and 80% project to the LGN; at least 30% of all RGCs must therefore project to both the SC and LGN via axon collaterals (Kelly and Gilbert, 1975; Illing, 1980; Illing and Wässle, 1981; Wässle, 1982; Farid Ahmed et al, 1984; Kondo et al, 1993,1994). Intrinsically photosensitive retinal ganglion cells (ipRGCs) that innervate the hypothalamic suprachiasmatic nucleus (SCN), a circadian clock, send collateral branches to the intergeniculate leaflet (IGL), the SC and the olivary pretectal nucleus (OPN) (Pickard, 1985; Morin et al, 2003; Baver et al, 2008).…”

Section: The Visual System: Parallel Streams Of Signals From the Rmentioning

confidence: 99%

Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?

Pickard

2015

Neuroscience & Biobehavioral Reviews

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Retinal ganglion Y (alpha) cells are found in retinas ranging from frogs to mice to primates. The highly conserved nature of the large, fast conducting retinal Y cell is a testament to its fundamental task, although precisely what this task is remained ill-defined. The recent discovery that Y-alpha retinal ganglion cells send axon collaterals to the serotonergic dorsal raphe nucleus (DRN) in addition to the lateral geniculate nucleus (LGN), medial interlaminar nucleus (MIN), pretectum and the superior colliculus (SC) has offered new insights into the important survival tasks performed by these cells with highly branched axons. We propose that in addition to its role in visual perception, the Y-alpha retinal ganglion cell provides concurrent signals via axon collaterals to the DRN, the major source of serotonergic afferents to the forebrain, to dramatically inhibit 5-HT activity during orientation or alerting/escape responses, which dis-facilitates ongoing tonic motor activity while dis-inhibiting sensory information processing throughout the visual system. The new data provide a fresh view of these evolutionarily old retinal ganglion cells.

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Retrograde double-labeling study of retinal ganglion cells from the ipsilateral vLGN and SC in the albino rat

Cited by 8 publications

References 18 publications

Types of Parvalbumin-Containing Retinotectal Ganglion Cells in Mouse

Types of Parvalbumin-Containing Retinotectal Ganglion Cells in Mouse

Retrograde Tracing with Fluorescent Microspheres Reveals Bifurcating Projections from Central Retina to Tectum and Thalamus in Chicks

Dorsal raphe nucleus projecting retinal ganglion cells: Why Y cells?

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