Retroperitoneal and inguinal manifestation of malignant fibrous histiocytoma

Adolphs, H.-D.; Helpap, B.; Koischwitz, D

doi:10.1016/0090-4295(82)90322-3

Cited by 14 publications

(4 citation statements)

References 23 publications

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“…Malignant fibrous histiocytoma was first described by O'Brien and Stout in 1964 [11] and is the commonest type of soft tissue sarcoma [1][2][3]. The histologic types of the tumor vary considerably for different regions of the body and have been well described [12].…”

Section: Discussionmentioning

confidence: 99%

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Primary Renal Malignant Fibrous Histiocytoma

Ptochos

Karydas²,

Iosifidis³

et al. 1999

Urol Int

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Section: Discussionmentioning

confidence: 99%

“…Malignant fibrous histiocytoma (MFH), although rare, is considered the most common soft tissue sarcoma of adult life [1][2][3]. It is also reported in the pediatric population [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Primary Renal Malignant Fibrous Histiocytoma

Ptochos

Karydas²,

Iosifidis³

et al. 1999

Urol Int

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“…On the other hand, tumor size, necrosis, and predominance of histiocytic versus fibroblastic cell types, have little or no prognostic significance. 2 The high-grade (grade 111) nature of this malignant fibrous histiocytoma and the tumor stage (Tl, NO, MO stage IIIA according to the AJC Task Force on Soft-Tissue Sarcomas)12 places our patient at great risk for developing distant metastases.12…”

Section: Tionsmentioning

confidence: 99%

“…It is the most common soft-tissue sarcoma of late adult life, accounting for approximately 10% of all sarcomas but only 1% of all malignancies. 2 The classic histologic features include spindle (fibroblastlike) and rounded (histiocytic-like) cells arranged in storiform patterns accompanied by pleomorphic giant cells and inflammatory cells. The stroma may demonstrate myxoid components.'…”

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confidence: 99%

Doppler color flow findings in malignant fibrous histiocytoma of the scrotum and perineum

Karcnik

Rubenstein

Swayne

et al. 1994

J of Clinical Ultrasound

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Malignant fibrous histiocytoma (MFH) is a predominantly pleomorphic sarcoma that arises in the deep, soft tissues of the extremities and, in about 16% of cases, in the retroperitoneum.' It is the most common soft-tissue sarcoma of late adult life, accounting for approximately 10% of all sarcomas but only 1% of all malignancies.2 The classic histologic features include spindle (fibroblastlike) and rounded (histiocytic-like) cells arranged in storiform patterns accompanied by pleomorphic giant cells and inflammatory cells. The stroma may demonstrate myxoid components.' Any involvement of the inguinal region appears to be extremely rare, with only 2 cases involving the paratesticuladinguinal region2 and 12 cases involving the spermatic cord appearing in the lite r a t~r e .~We report an unusual case of malignant fibrous histiocytoma in a young man, arising in the deep subcutis layer of the left scrotum and involving the adjacent perineum. Examination with color flow doppler ultrasound showed tumor neovascularity and a low impedance flow characteristic. CASE REPORTA 24-year-old Hispanic man presented to surgical clinic with a 1-month history of a rapidly enlarging, firm mass behind the left testicle near the perineo-scrota1 junction. Real-time ultrasound examination utilizing a 7.5-MHz linear array/ color doppler transducer (Diasonics Spectra; Milpitas, California) demonstrated a 3.7 cm x 2.8 cm x 2.9 cm echogenic, solid, vascular mass adjacent 556to the left testicle and within the scrotum near the perineo-scrota1 junction (Figure 1). Spectral doppler waveform analysis demonstrated lowresistance type tumor neovascularity; average pulsatility index (PI) = 0.68 (Figure 2). A subsequent CT scan of the abdomen and pelvis demonstrated no evidence of metastatic disease.Two weeks later, the patient was admitted to the hospital for a left inguinal exploration and excision of the perineo-scrota1 mass. At surgery the mass measured 4.5 cm in diameter, having increased in size by more than 50% during the 2-week interval. Examination of surgical specimen revealed spindle cells in storiform whirls with high-grade mitotic activity and a variable amount of myxoid extracellular matrix. The tumor was poorly circumscribed and focal microscopic invasion of the surgical margins was evident.Subsequently, the patient was readmitted for a radical perineal resection, left orchiectomy and left scrotectomy. Examination of the re-excision specimen revealed clear surgical margins. Once again, the microscopic findings were consistent with a high-grade sarcoma such as malignant fibrous histiocytoma or rhabdomyosarcoma. Immunohistochemical staining, however, revealed a diffuse positive reaction t o alpha-1-antitrypsin antibodies, suggesting a fibrous histiocytic origin. The patient's postoperative course was uneventful, and he was started on a 6-week course of outpatient radiation therapy (6,000 cGy delivered to the perineum with special precautions for shielding of the right testicle); chemotherapy was also planned. DISCUSSIONConventional gray-s...

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Tumoren des Hodens

Helpap

1993

Atlas Der Pathologie Urologischer Tumoren

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Retroperitoneal and inguinal manifestation of malignant fibrous histiocytoma

Cited by 14 publications

References 23 publications

Primary Renal Malignant Fibrous Histiocytoma

Primary Renal Malignant Fibrous Histiocytoma

Doppler color flow findings in malignant fibrous histiocytoma of the scrotum and perineum

Tumoren des Hodens

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